| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
The mechanism of water electrolyte metabolism of teleost fishes during acclimation to fresh water and seawater has become clearer at molecular level by the identification of membrane transport proteins in transport epithelia of the gill, intestine and kidney. The functions of the gill, intestine, and kidney are regulated by various hormones, however the mechanisms of hormonal regulations of these membrane transport proteins have not been clarified yet. We expressed various membrane transport proteins in Xenopus oocytes and analyzed the functions by electrophysiology. Expression analysis of a marine pufferfish Takifugu rubripes identified hormone receptors, aquaporins and a potassium channel expressed in the collecting duct cells, and proposed a novel model to explain the regulation of water reabsorption of the kidney of a marine teleost.
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