Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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Outline of Final Research Achievements |
This study showed that ovarian follicular exosomes are mainly produced by ovarian mural granulosa cells (MGCs) in mammals. The follicular exosomes are taken-up by ovarian cells to regulate hormonal production and development of oocytes. Normal follicular development requires factors secreted from oocytes, but the oocyte factors show no effects on the exosome release by MGCs. Moreover, we have produced a mouse model for the study of exosome function in ovaries.
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