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Analysis of the molecular mechanism for the increase in the virulence of Marek's disease virus

Research Project

Project/Area Number 17H03911
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Veterinary medical science
Research InstitutionHokkaido University

Principal Investigator

Ohashi Kazuhiko  北海道大学, 獣医学研究院, 教授 (90250498)

Co-Investigator(Kenkyū-buntansha) 村田 史郎  北海道大学, 獣医学研究院, 助教 (10579163)
今内 覚  北海道大学, 獣医学研究院, 准教授 (40396304)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywordsマレック病 / マレック病ウイルス
Outline of Final Research Achievements

Marek’s disease virus (MDV), a causative agents of Marek’s disease (MD), which is characterized by the formation of malignant lymphoma, appears to increase its virulence in the fields. To elucidate the molecular mechanisms for the increase in its virulence, we isolated MDVs from vaccinated chickens which still developed clinical MD, and analyzed their virological properties. MDV recently isolated in Japan caused clinical MD in inoculated chickens, although less virulent to chickens compared to virulent MDV strains isolated in United States. In addition, it is suggested that virus-derived factors other than polymorphisms in viral oncogene reported in the United States would be involved in the increase in MDV virulence.

Academic Significance and Societal Importance of the Research Achievements

マレック病は、養鶏業に被害をもたらす重要な疾病であるが、現在はワクチン接種により制御されている。しかしマレック病ウイルスの病原性進化によるワクチンブレークが世界各地で報告されており、その病原性進化の分子機構を明らかにして、新規防除法を確立することは、養鶏業に大きく貢献するものである。今回の研究で、国内でのマレック病ウイルスの病原性進化には、これまで米国で示唆されたいたウイルス性因子以外のもの関与することが判明し、今後新たな防除法の確立に向けて貢献できるものと考えられる。しかしながら、その因子の同定までは至らず今後さらなる分子機構の解明が必要である。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (8 results)

All 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Molecular detection and genetic characterization of Mycoplasma gallisepticum, Mycoplama synoviae, and infectious bronchitis virus in poultry in Myanmar2019

    • Author(s)
      Fujisawa S, Murata S, Takehara M, Katakura K, Hmoon MM, Win SY, Ohashi K.
    • Journal Title

      BMC Veterinary Research

      Volume: 15 Issue: 1 Pages: 261-261

    • DOI

      10.1186/s12917-019-2018-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Haematophagous mites on poultry farms in the Republic of the Union of Myanmar2019

    • Author(s)
      Takehara M, Murata S, Katakura K, Fujisawa S, Hmoon MM, Win SY, Bawm S, Htun LL, Aung YH, Win MM, Isezaki M, Maekawa N, Okagawa T, Konnai S, Ohashi K.
    • Journal Title

      Heliyon

      Volume: 5 Issue: 4 Pages: e01544-e01544

    • DOI

      10.1016/j.heliyon.2019.e01544

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Molecular detection and genetic characterization of mycoplasmas, infectious bronchitis virus and infectious laryngotracheitis virus in poultry farms in Myanmar2019

    • Author(s)
      Zhiyuan Yang、藤澤宗太郎、村田史郎、竹原昌生、片倉賢、Hmoon Myint Myint、Win Shwe Yee、Bawm Saw、Htun Lat Lat、Aung Ye Htut、 Win Mar Mar、今内覚、大橋和彦
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] RNA-Seqを用いたワクモ(Dermanyssus gallinae)の吸血状態別における遺伝子発現解析2019

    • Author(s)
      藤澤宗太郎、村田史郎、竹原昌生、伊勢崎政美、小川遼、宇野有紀子、 種子野章、前川直也、岡川朋弘、今内覚、大橋和彦
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ワクモ由来Adipocyte plasma membrane-associated proteinの抗ワクモワクチン抗原としての評価2019

    • Author(s)
      森田鮎、竹原昌生、村田史郎、伊勢崎政美、藤澤宗太郎、種子野章、 酒井英史、宇野有紀子、小川遼、市居修、前川直也、岡川朋弘、 今内覚、大橋和彦
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マレック病ウイルスの病原性進化機構の解明ー病原性試験や全ゲノム解析の試み2018

    • Author(s)
      大橋和彦、村田史郎、町田柚香、伊勢崎政美、 今内覚
    • Organizer
      第161回日本獣医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Molecular detection of Marek's disease virus in poultry farms in Myanmar2018

    • Author(s)
      Shiro Murata、Masaki Takehara、Ken Katakura、Myint Myint Hmoon、Shwe Yee Win、Masayoshi Isezaki、Satoru Konnai、Kazuhiko Ohashi
    • Organizer
      The 12th International Symposium on Marek’s disease and Avian Herpesviruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日本に分布するマレック病ウイルス野外株の病原性の検討2018

    • Author(s)
      村田史郎、種子野章、酒井英史、町田柚香、松山あゆ美、伊勢崎政美、今内覚、大橋 和彦
    • Organizer
      第160回日本獣医学会
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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