Comprehensive analyses in components of Toxoplasma dormant parasites.
| Project/Area Number |
17H03913
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Tohoku University (2018-2020)
Obihiro University of Agriculture and Veterinary Medicine (2017) |
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Principal Investigator |
KATO Kentaro 東北大学, 農学研究科, 教授 (30401178)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | トキソプラズマ / 原虫 / 潜伏感染 / 感染症 / 抗原虫薬 / 人獣共通感染症 |
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| Outline of Final Research Achievements |
This research focuses on molecular mechanism of Toxoplasma latent infection, which has not been studied yet. By the characterization of cyst, a dormant parasite, which is a source of infection, we performed to select parasite factors enough which can be targeted for anti-parasite drugs. At first, we detected the parasite factors constituting cyst wall comprehensively in the dormant Toxoplasma-infected cells. Moreover, we characterized the detected parasite factors in the latent infection.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、トキソプラズマの潜伏感染虫体の性状解析を行ったが、ここで得られた知見は休眠型虫体を持つ三日熱マラリア等の他の原虫のライフサイクルの理解とその感染阻止につながる。本研究で同定した潜伏感染制御因子は、トキソプラズマの潜伏感染阻止薬の開発に結び付くことが期待できる。このような新規の薬剤は、食肉となる家畜の感染阻止、食品価値の向上に役立つだけでなく、近年産婦人科領域で問題となっている妊婦でのトキソプラズマ初感染時の処方薬としての利用が期待できる。
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Tree of motility;A proposed history of motility systems in the tree of life2020
Author(s)
M Miyata, R C Robinson, T QP Uyeda, Y Fukumori, S Fukushima, S Haruta, M Homma, K Inaba, M Ito, C Kaito, K Kato, TKenri, Y Kinosita, S Kojima, T Minamino, H Mori, S Nakamura, D Nakane, K Nakayama, M Nishiyama, S Shibata, K Shimabukuro, M Tamakoshi, A Taoka, Y Tashiro, ITulum, HiWada, K Wakabayashi
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Journal Title
Genes to Cells
Volume: 25
Issue: 1
Pages: 6-21
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Metal nanoparticles restrict the growth of protozoan parasites2018
Author(s)
Adeyemi Oluyomi Stephen、Molefe Nthatisi Innocentia、Awakan Oluwakemi Josephine、Nwonuma Charles Obiora、Alejolowo Omokolade Oluwaseyi、Olaolu Tomilola、Maimako Rotdelmwa Filibus、Suganuma Keisuke、Han Yongmei、Kato Kentaro
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Journal Title
Artificial Cells, Nanomedicine, and Biotechnology
Volume: 46
Issue: sup3
Pages: 86-94
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Toxoplasma gondii RON4 binds to heparan sulfate on the host cell surface2018
Author(s)
Takemae, H., Kobayashi, K., Sugi, T., Han, Y., Gong, H., Ishiwa, A., Recuenco, F. C., Murakoshi, F., Takano, R., Murata, Y., Nagamune, K., Horimoto, T., Akashi, H., Kato, K.
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Journal Title
Parasitol. Int.
Volume: 67
Issue: 2
Pages: 123-130
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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