| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
Many pathogenic bacteria do not exhibit pathogenicity in natural hosts and are considered to be in a symbiotic relationship. The purpose of this study is to analyze the mechanism and apply it to elucidate the mechanism of proliferation and symbiosis (dormant) of intracellular bacteria in susceptible hosts. In this study, we used Francisella tularensis and F. novicida as representatives of intracellular bacteria, and examined comparative analysis of their behavior in natural and susceptible hosts. As a result, we identified multiple factors involved in intracellular growth and symbiosis, and clarified a part of the mechanism of bacteria-host interaction.
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