| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
Visceral obesity is the major risk factor for cardiovascular diseases (CVD). Adipose tissue-derived cytokine (adipocytokine) links visceral obesity to pathogenesis of CVD. This study aimed to explore the adipocytokine regulatory mechanisms of CVD specifically focusing on blood vessels, heart, and brain. We for the first time revealed that (1) adipocytokine chemerin may mediate the development of pulmonary hypertension, (2) chemerin mediates systemic hypertension through the action on central nerves, (3) chemerin affects the contractility and beating of the heart.
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