| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
We have found that progranulin (PGRN), which is known to have neuroprotective properties, is a kind of lysosomal proteins. In this study, we investigated the involvement of PGRN in maintaining homeostasis of nervous/muscular tissues. We found that PGRN suppresses excessive excitatory responses of neurons to seizure-inducible drugs, maintains adult hippocampal neurogenesis by attenuating neuroinflammation under acute immune stress, and promotes integrated muscular regeneration by regulating the dynamics of macrophages after muscular injury.
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