| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
Autophagy has important roles to control the nutrient metabolisms in cell, especially while the cell starvation. The autophagosome formation and its fusion to the lysosome have essential roles for the autophagy and it must be important to interpretate their mechanisms for understanding the control mechanisms of the autophagy. The lipid bilayers are important for the formation of the autophagosome same as other intracellular organelles inside cell. In this study, we found that phosphatidylinositol 4-phosphate and phosphatidylserine were specifically localized in the membrane of the autophagosome in mammalian and yeast cells and phosphatidylinositol 4-kinases were involved in the formation of the autophagosome and the fusion to the lysosome/vacuole.
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