| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
The purpose of this study is to investigate the roles and regulatory mechanisms of key genes for insect metamorphosis. By using the silkworm (Bombyx mori) as a experimental model, we revealed the roles of Kr-h1, a transcription factor that mediates anti-metamorphic action of juvenile hormones (JHs), broad, a transcription factor that acts as a pupal specifier, and E93, a transcription factor that triggers adult morphogenesis. Our experiments using knockout silkworms also demonstrated the molecular mechanisms of genetic interaction of these transcription factors. We further showed that how the number of larval molts are determined in the silkworm. Collectively, our results will lead to a better understanding of physiological and endocrinological control of insect metamorphosis.
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