| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Synthetic study of organic molecules that contain poly-cyclic skeletons is a crucial technology to develop in medicinal chemistry.
We have been studying an asymmetric Diels-Alder reaction using electron-rich butadiene derivatives so-called Danishefsky diene under our original lanthanoid catalyst. Using this reaction, we develop new synthetic routes to prepare synthetic intermediates for terpene, and also carbazole natural products. We also succeeded to prepare new and stable lantanoid complexes which promoted this type of Diels-Alder reactions. Finally, we coulde proped biological functions of schizocommunin which activate aryl hydrocarbon receptor (AhR).
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