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Development of Direct Catalytic Synthesis of Primary Amine Containing Chiral Tetrasubstituted Carbon Using Unprotected Ketimine

Research Project

Project/Area Number 17H03972
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionKyushu University

Principal Investigator

Ohshima Takashi  九州大学, 薬学研究院, 教授 (10313123)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords無保護ケチミン / 不斉四置換炭素含有第一級アミン / 非天然アミノ酸 / 直接的触媒反応 / one-pot連続反応 / N無保護ケチミン / 非天然α-アミノ酸
Outline of Final Research Achievements

To develop an environmentally friendly synthetic process for optically active primary amines containing chiral tetra-substituted carbons, we researched to create next-generation direct catalytic reactions using unprotected ketimine as a substrate.
After three years of research, we succeeded in developing the alkynylation reaction, the Mannich type reaction, the Friedel-Crafts type reaction, the decarboxylative Mannich reaction, and the Arylation reaction using Ar boronic acid, and the target compounds were obtained in high yield with high enantioselectivity. Moreover, we succeeded in developing a new environmentally friendly synthetic method, which can directly and catalytically synthesize unprotected ketimines from the corresponding ketones. We also succeeded in one-pot continuous reactions from ketones to primary amines.

Academic Significance and Societal Importance of the Research Achievements

医薬品などの重要機能性分子の合成に必要な不斉四置換炭素含有光学活性第一級アミンを、大量かつ地球環境に負荷をかけることなく実用的に供給する方法の開発は、「廃棄物を出しながら目的物を合成する従来の化学」から本来不必要な廃棄物を出さない「地球環境に優しいグリーンな化学」への変換に貢献するものである。
これまで反応基質として用いられてこなかった無保護ケチミンを基質に用いることで、本質的には不必要な官能基の保護・脱保護のプロセスや活性化のプロセスを排除した、次世代型の直接的触媒反応が可能となった。本研究は、基礎研究として重要なだけではなく、創薬化学、機能性材料化学の分野の発展にも大きく寄与するものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (193 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (22 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 22 results,  Open Access: 4 results) Presentation (160 results) (of which Int'l Joint Research: 44 results,  Invited: 34 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Nanyang Technological University(シンガポール)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] 南洋理工大学(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 南洋理工大学(シンガポール)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Rhodium(I)/Chiral Diene-Catalyzed Enantioselective Addition of Boronic Acids to N-Unsubstituted Isatin-Derived Ketimines2020

    • Author(s)
      Yonesaki, R.; Kusagawa, I.; Morimoto, H.; Hayashi, T.; Ohshima, T.
    • Journal Title

      Chem. Asian. J.

      Volume: 15 Issue: 4 Pages: 499-502

    • DOI

      10.1002/asia.201901745

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recent Progress towards the Use of Benzophenone Imines as an Ammonia Equivalent2020

    • Author(s)
      Kondo, Y.; Morimoto, H.; Ohshima, T.
    • Journal Title

      Chem. Lett.

      Volume: 49 Issue: 5 Pages: 497-504

    • DOI

      10.1246/cl.200099

    • NAID

      130007840173

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemoselective Catalytic α-Oxidation of Carboxylic Acids: Iron/Alkali Metal Cooperative Redox Active Catalysis2020

    • Author(s)
      Tanaka Tsukushi、Yazaki Ryo、Ohshima Takashi
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 9 Pages: 4517-4524

    • DOI

      10.1021/jacs.0c00727

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amino Acid Schiff Base Bearing Benzophenone Imine As a Platform for Highly Congested Unnatural a-Amino Acid Synthesis2020

    • Author(s)
      Matsumoto, Y.; Sawamura, J.; Murata, Y.; Nishikata, T.; Yazaki, R.; Ohshima, T.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 142 Issue: 18 Pages: 8498-8505

    • DOI

      10.1021/jacs.0c02707

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Convenient Preparation Method for Benzophenone Imine Catalyzed by Tetrabutylammonium Fluoride2019

    • Author(s)
      Kondo Yuta、Morisaki Kazuhiro、Hirazawa Yoshinobu、Morimoto Hiroyuki、Ohshima Takashi
    • Journal Title

      Organic Process Research & Development

      Volume: 23 Issue: 8 Pages: 1718-1724

    • DOI

      10.1021/acs.oprd.9b00226

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent strategic advances for the activation of benzylic C?H bonds for the formation of C?C bonds2019

    • Author(s)
      Yazaki Ryo、Ohshima Takashi
    • Journal Title

      Tetrahedron Letters

      Volume: 60 Issue: 45 Pages: 151225-151225

    • DOI

      10.1016/j.tetlet.2019.151225

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10.2019

    • Author(s)
      Yokoyama T., Yukuhiro M., Iwasaki Y., Tanaka C., Sankoda K., Fujiwara R., Shibuta A., Higashi T., Motoyama K., Arima H., Yoshida K., Sugimoto N., Morimoto H., Kosako H., Ohshima T. and Fujita M.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41598-019-53259-2

    • NAID

      120006875663

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines2019

    • Author(s)
      Kondo Yuta、Kadota Tetsuya、Hirazawa Yoshinobu、Morisaki Kazuhiro、Morimoto Hiroyuki、Ohshima Takashi
    • Journal Title

      Organic Letters

      Volume: 22 Issue: 1 Pages: 120-125

    • DOI

      10.1021/acs.orglett.9b04038

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MECHANISTIC INSIGHT INTO CATALYTIC AEROBIC CHEMOSELECTIVE α-OXIDATION OF ACYLPYRAZOLES2019

    • Author(s)
      Taninokuchi, S.; Yazaki, R.; Ohshima, T.
    • Journal Title

      Heterocycles

      Volume: - Issue: 2 Pages: 906-906

    • DOI

      10.3987/com-18-s(f)58

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process2019

    • Author(s)
      Noshita, M.; Shimizu, Y.; Morimoto, H.; Akai, S.; Hamashima, Y.; Ohneda, N.; Odajima, H.; Ohshima, T.
    • Journal Title

      Org. Process Res. Dev.

      Volume: - Issue: 4 Pages: 588-594

    • DOI

      10.1021/acs.oprd.8b00424

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thionoesters as 1,2-Dipolarophiles for [4+2] Cycloaddition with Cyclobutanones2019

    • Author(s)
      Matsumoto, Y.; Tsuji, T.; Nakatake, D.; Yazaki, R.; Ohshima, T.
    • Journal Title

      Asian J. Org. Chem.

      Volume: - Issue: 7 Pages: 1071-1074

    • DOI

      10.1002/ajoc.201900156

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N_Unprotected Isatin-Derived Ketimines2018

    • Author(s)
      Sawa, M.; Miyazaki, S.; Yonesaki, R.; Morimoto, H.; Ohshima, T.
    • Journal Title

      Org. Lett.

      Volume: 20 Issue: 17 Pages: 5393-5397

    • DOI

      10.1021/acs.orglett.8b02306

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3-Mono-Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel-Crafts-Type Alkylation of N-Unprotected a-Ketiminoester2018

    • Author(s)
      Yonesaki, R.; Kondo, Y.; Akkad, W.; Sawa, M.; Morisaki, K.; Morimoto, H.; Ohshima, T.
    • Journal Title

      Chem. Eur. J.

      Volume: 24 Issue: 57 Pages: 15211-15214

    • DOI

      10.1002/chem.201804078

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer2018

    • Author(s)
      Tanaka, T.; Tanaka, T.; Tsuji, T.; Yazaki, R.; Ohshima, T.
    • Journal Title

      Org. Lett.

      Volume: 20 Issue: 12 Pages: 3541-3544

    • DOI

      10.1021/acs.orglett.8b01313

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth suppression of human colorectal cancer cells with mutated KRAS by 3-deaza-cytarabine in 3d floating culture2018

    • Author(s)
      Luo, H.; Nishi, K.; Ishikura, S.; Swain, A.; Morishige, N.; Yazaki, R.; Ohshima, T.; Shirasawa, S.; Tsunoda, T.
    • Journal Title

      Anticancer research

      Volume: 38 Issue: 7 Pages: 4247-4256

    • DOI

      10.21873/anticanres.12721

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Direct Enantioselective Alkynylation of α-Ketoester and α-Ketiminoesters Catalyzed by Phenylbis(oxazoline)Rh(III) Complexes2018

    • Author(s)
      森崎 一宏、森本 浩之、真島 和志、大嶋 孝志
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 76 Issue: 3 Pages: 226-240

    • DOI

      10.5059/yukigoseikyokaishi.76.226

    • NAID

      130006449132

    • ISSN
      0037-9980, 1883-6526
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bioconjugation with Thiols by Benzylic Substitution2018

    • Author(s)
      Kenji Watanabe and Takashi Oshima
    • Journal Title

      Chemistry―A European Journal

      Volume: 24 Issue: 16 Pages: 3959-3964

    • DOI

      10.1002/chem.201706149

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Expeditious Route to trans-Configured Tetrahydrothiophenes Enabled by Fe(OTf)3-Catalyzed [3+2] Cycloaddition of Donor-Acceptor Cyclopropanes with Thionoesters2018

    • Author(s)
      Matsumoto Yohei、Nakatake Daiki、Yazaki Ryo、Ohshima Takashi
    • Journal Title

      Chemistry - A European Journal

      Volume: 24 Issue: 23 Pages: 6062-6066

    • DOI

      10.1002/chem.201800957

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catalytic Aerobic Chemoselective α-Oxidation of Acylpyrazoles en Route to α-Hydroxy Acid Derivatives2017

    • Author(s)
      Taninokuchi Seiya、Yazaki Ryo、Ohshima Takashi
    • Journal Title

      Organic Letters

      Volume: 19 Issue: 12 Pages: 3187-3190

    • DOI

      10.1021/acs.orglett.7b01293

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct access to N-unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines2017

    • Author(s)
      Morisaki Kazuhiro、Morimoto Hiroyuki、Ohshima Takashi
    • Journal Title

      Chemical Communications

      Volume: 53 Issue: 47 Pages: 6319-6322

    • DOI

      10.1039/c7cc02194a

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Access to N-Unprotected α- and/or β-Tetrasubstituted Amino Acid Esters via Direct Catalytic Mannich-Type Reactions Using N-Unprotected Trifluoromethyl Ketimines2017

    • Author(s)
      Sawa Masanao、Morisaki Kazuhiro、Kondo Yuta、Morimoto Hiroyuki、Ohshima Takashi
    • Journal Title

      Chemistry - A European Journal

      Volume: 23 Issue: 67 Pages: 17022-17028

    • DOI

      10.1002/chem.201703516

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Boronic Acid Accelerated Three-Component Reaction for the Synthesis of α-Sulfanyl-Substituted Indole-3-acetic Acids2017

    • Author(s)
      Amrita Das, Kenji Watanabe, Hiroyuki Morimoto and Takashi Ohshima
    • Journal Title

      Organic Letters

      Volume: 19 Issue: 21 Pages: 5794-5797

    • DOI

      10.1021/acs.orglett.7b02727

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of novel catalytic synthetic methods of N-unprotected ketimines and its application to one-pot reactions2020

    • Author(s)
      Hiroyuki Morimoto, Yuta Kondo, Tetsuya Kadota, Kazuhiro Morisaki, Yoshinobu Hirazawa, Takashi Ohshima
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of New Catalytic Synthetic Methods of N-Unprotected Ketimines and Application to One-Pot Reactions2020

    • Author(s)
      森本浩之
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 化学選択性の精密制御のための触媒反応開発2020

    • Author(s)
      矢崎亮
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 遷移金属触媒を用いた窒素上無保護ケチミンに対する新規触媒反応の開発2020

    • Author(s)
      米嵜 凌平、草川 伊吹、森本 浩之、林 民生、大嶋 孝志
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラジカル機構によるカルボン酸の触媒的α_酸化反応2020

    • Author(s)
      田中津久志、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 触媒的酸化的クロスカップリング反応を用いたα、β-連続四置換炭素含有α-アミノ酸の合成2020

    • Author(s)
      橋口佳代子、吉田真奈、池田哲、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] α-アミノ酸誘導体のβ位アミノ化反応の開発2020

    • Author(s)
      田渕友梨、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] TBAF触媒による窒素上無保護ケチミン合成法の開発とワンポット反応への応用2020

    • Author(s)
      平澤 禎将、近藤 優太、森崎 一宏、森本 浩之、大嶋 孝志
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The Utility of Thionoesters as 1,2-Dipolarophile for Cycloaddition Reactions2019

    • Author(s)
      Yohei Matsumoto, Daiki Nakatake, Taro Tsuji, Ryo Yazaki, Takashi Ohshima
    • Organizer
      The 27th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法の開発2019

    • Author(s)
      近藤優太、門田哲弥、平澤禎将、森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第29回万有福岡シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of Direct Catalysis for the Synthesis of Unnatural a-Amino Acid Derivatives2019

    • Author(s)
      Takashi Ohshima
    • Organizer
      the 2019 National Taiwan Normal University (NTNU)-Kyushu University Joint Forum on Facilitating Interdisciplinary Research and Education
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Catalytic Oxidative α-Benzylation of Carboxylic Acid Equivalents2019

    • Author(s)
      Tsukushi Tanaka, Kayoko Hashiguchi, Takafumi Tanaka, Ryo Yazaki and Takashi Ohshima
    • Organizer
      The 1st International Symposium on Hybrid Catalysis
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Unactivated Bond Cleavage and Its Application for Removal of Directing Groups2019

    • Author(s)
      Hai-Long Xin, Toru Deguchi, Walaa Akkad, Hiroyuki Morimoto, and Takashi Ohshima
    • Organizer
      第17回次世代を担う有機化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンに対する触媒的求核付加反応の開発2019

    • Author(s)
      森本浩之、森崎一宏、澤真尚、宮崎翔太郎、米嵜凌平、大嶋孝志
    • Organizer
      第115回有機合成シンポジウム2019年【春】
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新規BINOLリン酸触媒による窒素上無保護α-ケチミノエステルに対する不斉Friedel-Craftsアルキル化反応の開発2019

    • Author(s)
      米嵜 凌平、近藤 優太、Akkad Walaa、澤 真尚、森崎 一宏、森本 浩之、大嶋 孝志
    • Organizer
      第8回 JACI/GSCシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法の開発2019

    • Author(s)
      門田哲弥、平澤禎将、森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第56回化学関連支部合同九州大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 酸素雰囲気下におけるアミノ酸誘導体の触媒的脱水素型クロスカップリング反応の開発2019

    • Author(s)
      辻 汰朗、田中尊書、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第56回化学関連支部合同九州大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] パラジウム触媒によるマロノニトリルの直接的アルキル化におけるアリルアルコールとアリルアミンの化学選択的求電子的活性化2019

    • Author(s)
      Lu Lin、平山揮一、澁谷亮三、渡辺賢司、森本浩之、大嶋孝志
    • Organizer
      第56回化学関連支部合同九州大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Catalytic a-Amination of Acylpyrazoles and Catalytic Addition of Various Nucleophile to N-Unprotected Ketimines for the Synthesis of Unnatural a-Amino Acid Derivatives2019

    • Author(s)
      Takashi Ohshima
    • Organizer
      University of Strasbourg Department Seminar
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of New Catalytic Synthetic Methods of N-Unprotected Ketimines2019

    • Author(s)
      Hiroyuki Morimoto, Yuta Kondo, Kazuhiro Morisaki, Tetsuya Kadota, Yoshinobu Hirazawa, Takashi Ohshima
    • Organizer
      The 4rd International Symposium on Process Chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 環境調和反応の集積化2019

    • Author(s)
      大嶋孝志
    • Organizer
      一般社団法人近畿化学協会合成部会フロー・マイクロ合成研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Development of Unactivated Bond Cleavage and Its Application for The Removal of Directing Groups2019

    • Author(s)
      Hai-Long Xin, Toru Deguchi, Walaa Akkad, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      258nd American Chemical Society National Meeting & Exposition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法の開発2019

    • Author(s)
      門田哲弥、平澤禎将、森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第31回若手研究者のためのセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] パラジウム触媒によるマロノニトリルの直接的アルキル化におけるアリルアルコールとアリルアミンの化学選択的求電子的活性化2019

    • Author(s)
      Lu Lin、平山揮一、澁谷亮三、渡辺賢司、森本浩之、大嶋孝志
    • Organizer
      第31回若手研究者のためのセミナー
    • Related Report
      2019 Annual Research Report
  • [Presentation] Acylpyrazole as Carboxylic Acid Equivalent Platform for Chemoselective Catalysis2019

    • Author(s)
      Ryo Yazaki, Seiya Taninokuchi, Keisuke Tokumasu, Tsukushi Tanaka and Takashi Ohshima
    • Organizer
      27th International Society of Heterocyclic Chemistry Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sterically Congested Cross Coupling Reaction for Amino Acid Synthesis2019

    • Author(s)
      Ryo Yazaki, Yohei Matsumoto, Jun Sawamura, Yumi Murata, Takashi Nishikata, Takashi Ohshima
    • Organizer
      第66回有機金属化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 官能基標的触媒による化学選択性の触媒制御を基盤とする複雑系分子の直接的変換反応の開発2019

    • Author(s)
      大嶋孝志
    • Organizer
      第36回有機合成化学セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2019

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第36回有機合成化学セミナー
    • Related Report
      2019 Annual Research Report
  • [Presentation] 官能基標的触媒による化学選択性の触媒制御2019

    • Author(s)
      大嶋孝志
    • Organizer
      第124回触媒討論会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] N-Unprotected Ketimines2019

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 14th International Conference on Cutting-Edge Organic Chemistry in Asia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Catalytic α_Functionalization of Carboxylic Acid Equivalents and Carboxylic Acids via Radical Process Molecular Recognition of Macromolecules for Artificial Enzyme2019

    • Author(s)
      田中津久志
    • Organizer
      第10回 大津会議 Otsu Conference 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 環境調和反応の集積化による効率的医薬品合成2019

    • Author(s)
      大嶋孝志
    • Organizer
      第9回CSJ化学フェスタ2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 窒素上無保護α - ケチミノエステルに対する直接的触媒的不斉求核付加反応の開発2019

    • Author(s)
      森本浩之,米嵜凌平,澤真尚,近藤優太,Walaa Akkad,森崎一宏,大嶋孝志
    • Organizer
      第45回反応と合成の進歩シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 触媒的酸化的クロスカップリング反応を用いたα,β_連続四置換炭素含有α-アミノ酸の合成2019

    • Author(s)
      橋口佳代子、吉田真奈、池田哲、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第45回反応と合成の進歩シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 官能基標的触媒による化学選択性の触媒制御を基盤とする複雑系分子の直接的変換反応の開発2019

    • Author(s)
      大嶋孝志
    • Organizer
      第116回有機合成シンポジウム2019年【秋】
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ラジカルクロスカップリングによるα,β-連続四置換炭素含有非天然型α-アミノ酸の合成2019

    • Author(s)
      松本洋平、澤村淳、村田祐美、西形孝司、矢崎亮、大嶋孝志
    • Organizer
      第116回有機合成シンポジウム2019年【秋】
    • Related Report
      2019 Annual Research Report
  • [Presentation] New Catalytic Synthetic Methods of N-Unprotected Ketimines2019

    • Author(s)
      Takashi Ohshima, Yuta Kondo, Kazuhiro Morisaki, Tetsuya Kadota, Yoshinobu Hirazawa, Hiroyuki Morimoto
    • Organizer
      Tateshina Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] (-)-(α)-カイニン酸前駆体の 連続フロー合成法の開発2019

    • Author(s)
      平山揮一、大嶋孝志
    • Organizer
      第36回日本薬学会九州支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 酸素雰囲気下におけるアミノ酸誘導体の触媒的脱水素型クロスカップリング反応の開発2019

    • Author(s)
      辻汰朗、田中尊書、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第36回日本薬学会九州支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンに対する触媒的不斉Strecker反応の開発2019

    • Author(s)
      門田哲弥、澤真尚、森本浩之、大嶋孝志
    • Organizer
      第36回日本薬学会九州支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラジカルクロスカップリングによるα,β-連続四置換炭素含有非天然型α-アミノ酸の合成2019

    • Author(s)
      松本洋平、澤村淳、村田祐美、西形孝司、矢崎亮、大嶋孝志
    • Organizer
      第36回日本薬学会九州支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] One-Pot Process Based on Sc-Catalyzed Direct N-Unprotected Ketimine Synthesis2019

    • Author(s)
      Takashi Ohshima
    • Organizer
      International Joint Symposium on Synthetic Organic Chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Catalytic a-Oxidation of Carboxylic Acids via Radical Process2019

    • Author(s)
      Tsukushi Tanaka, Ryo Yazaki, Takashi Ohshima
    • Organizer
      International Joint Symposium on Synthetic Organic Chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 無保護ケチミンへの触媒的脱炭酸的不斉Mannich型反応を活用した、光学活性無保護アミン類の直接合成法の開発2019

    • Author(s)
      宮崎翔太郎、澤真尚、米嵜凌平、森本浩之、大嶋孝志
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Recent Progress on the Synthesis of Unnatural a-Amino Acid Derivatives2019

    • Author(s)
      Takashi Ohshima
    • Organizer
      National Taiwan Normal University Department Seminar
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemoselective Catalytic a-Oxidation of Carboxylic Acids2019

    • Author(s)
      Tsukushi Tanaka, Ryo Yazaki, Takashi Ohshima
    • Organizer
      The 2nd Japan Germany Singapore Trilateral Symposium on Precision Synthesis and Catalysis and 4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radical Cross-Coupling of Amino Acid Schiff Bases for Highly Congested Unnatural α-Amino Acid Synthesis2019

    • Author(s)
      Yohei Matsumoto, Jun Sawamura, Yumi Murata, Takashi Nishikata, Ryo Yazaki, Takashi Ohshima
    • Organizer
      The 2nd Japan Germany Singapore Trilateral Symposium on Precision Synthesis and Catalysis and 4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent Progress on Catalytic Synthesis of Unnatural a-Amino Acid Derivatives2019

    • Author(s)
      Takashi Ohshima
    • Organizer
      Asian Core Program Lectureship (China)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Integration of Environmentally Friendly Direct Transformations2019

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 18th Asian Chemical Congress (ACC)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 官能基標的触媒による化学選択性の触媒制御2019

    • Author(s)
      大嶋孝志
    • Organizer
      The 2nd Nagoya Seminar on Green Synthesis & Catalysis
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] エステル交換反応に利用する高機能亜鉛触媒の開発2019

    • Author(s)
      中武大貴、横手友紀、松嶋義正、矢崎亮、大嶋孝志
    • Organizer
      第21回システム創薬リサーチコア研究会/第20回薬学研究院若手セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] 環境調和反応の集積化を目指して2019

    • Author(s)
      大嶋孝志
    • Organizer
      第6回 新学術領域「反応集積化が導く中分子戦略: 高次生物機能分子の創製」若手シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Development of Greener Synthetic Methods of Amines Having Tetrasubstituted Carbon Stereocenters2019

    • Author(s)
      森本浩之
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Uncatalyzed direct C-C Bond Cleavage of 2-Acylimidazoles2019

    • Author(s)
      XIN, Hailong; AKKAD, Walaa; MORIMOTO, Hiroyuki; OHSHIMA, Takashi
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Uncatalyzed direct C-C Bond Cleavage of 2-Acylimidazoles2019

    • Author(s)
      XIN, Hailong; AKKAD, Walaa; MORIMOTO, Hiroyuki; OHSHIMA, Takashi
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法の開発2019

    • Author(s)
      近藤優太、森崎一宏、平澤禎将、門田哲弥、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] チオノエステルとシクロブタノンの[4+2]環化付加反応によるテトラヒドロチオピランの合成2019

    • Author(s)
      松本洋平、中武大貴、辻汰朗、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する触媒的脱炭酸的不斉マンニッヒ型反応の進展2019

    • Author(s)
      宮崎翔太郎、澤真尚、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 低級エステルを原料とした化学反応開発2018

    • Author(s)
      中武大貴、松本洋平、横手友紀、松嶋義正、矢崎亮、大嶋孝志
    • Organizer
      第16回次世代を担う有機化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] チオノエステルを用いた環化付加反応~エステルの新たな可能性を拓く~2018

    • Author(s)
      中武大貴、松本洋平、矢崎亮、大嶋孝志
    • Organizer
      福岡万有福岡シンポジウム第12回三地区若手交歓会
    • Related Report
      2018 Annual Research Report
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2018

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第28回万有福岡シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Catalytic α-Amination of Acylpyrazoles and Catalytic Addition of Various Nucleophile to N-Unprotected α-Ketiminnoesters for the Synthesis of Unnatural α-Amino Acid Derivatives2018

    • Author(s)
      大嶋孝志
    • Organizer
      名古屋大学Organic Seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 無保護ケチミンへの直接的触媒的求核付加反応の開発2018

    • Author(s)
      大嶋孝志
    • Organizer
      新学術領域研究 「反応集積化が導く中分子戦略:高次生物機能分子の創製」第6回成果報告会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規BINOLリン酸触媒による窒素上無保護a-ケチミノエステルへの直接的不斉Friedel-Crafts反応の開発と反応機構解析2018

    • Author(s)
      米嵜 凌平、近藤 優太、Akkad Walaa、澤 真尚、森崎 一宏、森本 浩之、大嶋 孝志
    • Organizer
      第113回有機合成シンポジウム2018年【春】
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法の開発2018

    • Author(s)
      近藤 優太, 森崎 一宏, 平澤 禎将, 森本 浩之, 大嶋 孝志
    • Organizer
      第7回 JACI/GSCシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] β-C-H Amination of α-Amino Acid Derivatives2018

    • Author(s)
      Yuri Tabuchi、Seiya Taninokuchi、Ryo Yazaki、Takashi Ohshima
    • Organizer
      創薬懇話会2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanistic studies of BINOL-derived phosphoric acid as effective catalysts in direct enantioselective Friedel-Crafts-type alkylation of N-unprotectedα-ketiminoester2018

    • Author(s)
      Walaa Akkad, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      第55回化学関連支部合同九州大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] チオノエステルとDAシクロプロパンの触媒的[3+2]環化付加反応によるテトラヒドロチオフェンの合成2018

    • Author(s)
      松本洋平、中武大貴、矢崎亮、大嶋孝志
    • Organizer
      第55回化学関連支部合同九州大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する触媒的脱炭酸的不斉マンニッヒ型反応の開発2018

    • Author(s)
      宮崎翔太郎、米嵜凌平、森本浩之、大嶋孝志
    • Organizer
      第55回化学関連支部合同九州大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 保護基・活性化基に頼らない直接触媒反応2018

    • Author(s)
      大嶋 孝志
    • Organizer
      万有札幌シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Development of Mild and Selective Oxidative Heck Reaction to Derivatize Complex Molecules and Reactivity Study of Heteroarenes2018

    • Author(s)
      Takashi Ohshima, Das Amrita, Takumi Kimijima, Kenji Watanabe_
    • Organizer
      28th International Conference on Organometallic Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法開発2018

    • Author(s)
      近藤 優太, 森崎 一宏, 平澤 禎将, 森本 浩之, 大嶋 孝志
    • Organizer
      日本プロセス化学会2017サマーシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development and Mechanistic Studies of (Phebox)Rh(III)-Catalyzed Direct Enantioselective Alkynylation of α-Ketiminoesters2018

    • Author(s)
      Hiroyuki Morimoto, Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Kazushi Mashima, Takashi Ohshima
    • Organizer
      The 43rd International Conference on Coordination Chemistry (ICCC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Direct Catalysis without Using Protecting or Activating Group2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      Asian Core Program Lectureship (Taiwan)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Catalytic Addition of Various Nucleophile to N-Unprotected Ketimines for the Synthesis of Unnatural a-Amino Acid Derivatives2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 1st Scripps Korea Society Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 無保護ケチミンを活用した四置換炭素含有無保護アミノ酸誘導体の触媒的直接合成法の開発2018

    • Author(s)
      森本 浩之
    • Organizer
      第5回新学術領域研究「反応集積化が導く中分子戦略:高次生物機能分子の創製」若手シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Efficient use of lower ester compounds: Catalytic transesterification and cycloaddition2018

    • Author(s)
      Daiki Nakatake, Yohei Matsumoto, Ryo Yazaki, Takashi Ohshima
    • Organizer
      256nd American Chemical Society National Meeting & Exposition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catalytic Oxidative α-Benzylation of Carboxylic Acid Equivalents2018

    • Author(s)
      Tsukushi Tanaka, Kayoko Hashiguchi, Takafumi Tanaka, Ryo Yazaki, Takashi Ohshima
    • Organizer
      4th International Symposium on C-H Activation (ISCHA-4)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] チオノエステルとDAシクロプロパンの触媒的[3+2]環化付加反応によるテトラヒドロチオフェンの合成2018

    • Author(s)
      松本洋平、中武大貴、矢崎亮、大嶋孝志
    • Organizer
      第30回若手研究者のためのセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mechanistic studies of BINOL-derived phosphoric acid as effective catalysts in direct enantioselective Friedel-Crafts-type alkylation of N-unprotected alpha-ketiminoester2018

    • Author(s)
      Walaa Akkad, Ryohei Yonesaki, Yuta Kondo, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto and Takashi Ohshima
    • Organizer
      第30回若手研究者のためのセミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] 地球に優しい薬づくり グリーンファルマのためのグリーンケミストリー2018

    • Author(s)
      大嶋孝志
    • Organizer
      九州大学薬学部 公開講座
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] チオノエステルと DA シクロプロパンの触媒的[3+2]環化付加反応によるテトラヒドロチオフェンの合成2018

    • Author(s)
      松本洋平、中武大貴、矢崎亮、大嶋孝志
    • Organizer
      第48回複素環化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] イサチン由来の窒素上無保護のケチミンに対する触媒的脱炭酸的不斉マンニッヒ型反応の開発2018

    • Author(s)
      澤真尚、宮崎翔太郎、米嵜凌平、森本浩之、大嶋孝志
    • Organizer
      第48回複素環化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanistic studies of BINOL-derived phosphoric acid as effective catalysts in direct enantioselective Friedel-Crafts-type alkylation of N-unprotected alpha-ketiminoester2018

    • Author(s)
      Walaa Akkad, Ryohei Yonesaki, Yuta Kondo, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto and Takashi Ohshima
    • Organizer
      第20回システム創薬リサーチコア研究会/第19回薬学研究院若手セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] チオノエステルとDAシクロプロパンの触媒的[3+2]環化付加反応によるテトラヒドロチオフェンの合成2018

    • Author(s)
      松本洋平、中武大貴、矢崎亮、大嶋孝志
    • Organizer
      第35回有機合成化学セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] Uncatalyzed C_C bond cleavage of 2-acylimidazoles2018

    • Author(s)
      Hai-Long Xin, Walaa Akkad, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      The 35rd organic synthetic chemistry seminar
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンへの触媒的求核付加を活用した四置換炭素構築反応の開発2018

    • Author(s)
      森本浩之、森崎一宏、澤真尚、宮崎翔太郎、米嵜凌平、大嶋孝志
    • Organizer
      第65回有機金属化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アシルピラゾールをカルボン酸等価体プラットフォームとする化学選択的触媒反応2018

    • Author(s)
      矢崎亮、谷之口誠也、徳益圭祐、大嶋孝志
    • Organizer
      第60回天然有機化合物討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 化学選択性の精密制御のための触媒反応設計2018

    • Author(s)
      矢崎亮
    • Organizer
      第2回 産総研化学研究シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homo-Coupling Dimer2018

    • Author(s)
      Takashi Ohshima, Takafumi Tanaka, Tsukushi Tanaka, Taro Tsuji, Ryo Yazaki
    • Organizer
      The 13th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-13)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2-アシルイミダゾールの化学選択的な触媒的脱水素型クロスカップリング反応2018

    • Author(s)
      田中津久志,橋口佳代子,田中尊書,矢崎亮,大嶋孝志
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する直接的脱炭酸的不斉マンニッヒ型反応の開発2018

    • Author(s)
      宮崎翔太郎、米嵜凌平、森本浩之、大嶋孝志
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2018

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homo-Coupling Dimer2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      Tateshina Conference on Organic Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Uncatalyzed C_C bond cleavage of 2-acylimidazoles2018

    • Author(s)
      Hai-Long Xin, Walaa Akkad, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      The 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemoselective Catalytic Dehydrogenative Cross Coupling of 2-Acylimidazoles2018

    • Author(s)
      Ryo Yazaki, Tsukushi Tanaka, Kayoko Hashiguchi, Takafumi Tanaka, Takashi Ohshima
    • Organizer
      The 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護のケチミンに対する触媒的脱炭酸的不斉Mannich型反応の開発2018

    • Author(s)
      宮崎翔太郎、澤真尚、米嵜凌平、森本浩之、大嶋孝志
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 触媒的酸化的クロスカップリング反応を用いたα,β-連続四置換炭素含有α-アミノ酸の合成2018

    • Author(s)
      橋口佳代子、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] α-アミノ酸誘導体のβ位アミノ化反応の開発2018

    • Author(s)
      田渕 友梨、谷之口 誠也、矢崎亮、大嶋孝志
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 窒素上無保護ケチミンの新規触媒的直接合成法の開発2018

    • Author(s)
      近藤優太、森崎一宏、平澤禎将、門田哲弥、森本浩之、大嶋孝志
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 地球に優しい薬づくり グリーンファルマのためのグリーンケミストリー2018

    • Author(s)
      大嶋孝志
    • Organizer
      2018年度 よか薬会講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 保護基・活性化基に頼らない直接触媒反応2018

    • Author(s)
      大嶋孝志
    • Organizer
      平成30年度(後期)有機合成化学講習会「有機合成の底力 ―新手法・新材料・創薬― 」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homo-Coupling Dimer2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 13th International Symposium on Organic Reactions (ISOR-13)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Construction of Tetrasubstituted Carbon Stereocenters via Catalytic Nucleophilic Additions to N-Unprotected Ketimines2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      6th Japan_UK Symposium on Asymmetric Catalysis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Catalytic Chemoselective Cross-Enolate Coupling Reaction2018

    • Author(s)
      Takashi Ohshima, Takafumi Tanaka, Tsukushi Tanaka, Taro Tsuji and Ryo Yazaki
    • Organizer
      The 4th International Symposium on Middle Molecular Strategy (ISMMS-4)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護α-ケチミノエステルに対する有機触媒を用いた直接的不斉求核付加反応の開発2018

    • Author(s)
      森本浩之・米嵜凌平・澤真尚・近藤優太、Walaa Akkad・森崎一宏・大嶋孝志
    • Organizer
      第11回有機触媒シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] トリフルオロメチル基の特性を活かした触媒反応開発:リガンドとして、基質として2018

    • Author(s)
      大嶋孝志
    • Organizer
      2018 ハロゲン利用ミニシンポジウム(第11回臭素化学懇話会年会)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 化学選択性の精密制御のための触媒反応設計2018

    • Author(s)
      矢崎亮
    • Organizer
      第14回IoLコロキウム―特別講演会―
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Catalytic a-Amination of Acylpyrazoles and Catalytic Addition of Various Nucleophile to N-Unprotected a-Ketimins for the Synthesis of Unnatural a-Amino Acid Derivatives2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      Asian Core Program Lectureship (Singapore)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Direct Catalytic Asymmetric Addition of Various Nucleophiles to N-Unprotected Ketimines2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      IRCCS-JST CREST Joint Symposium (IMCE)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Direct Catalytic Chemoselective Oxidative Cross-Enolate Coupling Reaction Via a Transient Homo-Coupling Dimer2018

    • Author(s)
      Takafumi Tanaka, Tsukushi Tanaka, Ryo Yazaki, Takashi Ohshima
    • Organizer
      IRCCS-JST CREST Joint Symposium (IMCE)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catalytic Aerobic Chemoselective α-Oxidation of Acylpyrazoles2018

    • Author(s)
      Seiya Taninokuchi, Ryo Yazaki, Takashi Ohshima
    • Organizer
      IRCCS-JST CREST Joint Symposium (IMCE)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ni(II)-Catalyzed Direct Alcoholysis of Unactivated 8-Aminoquinoline Amides2018

    • Author(s)
      Toru Deguchi, Hai-Long Xin, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      IRCCS-JST CREST Joint Symposium (IMCE)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2018

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      IRCCS-JST CREST Joint Symposium (IMCE)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Catalytic Asymmetric Addition of Various Nucleophiles to N-Unprotected Ketimines2018

    • Author(s)
      Takashi Ohshima
    • Organizer
      International Congress on Pure & Applied Chemistry (ICPAC) 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemoselective Oxidative Cross-Enolate Coupling2018

    • Author(s)
      Yazaki Ryo, Tanaka Takafumi, Tanaka Tsukushi, Ohshima Takashi
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Direct Catalytic Alcoholysis of Unactivated 8 Aminoquinoline Amides2018

    • Author(s)
      DEGUCHI, Toru・XIN, Hailong・MORIMOTO, Hiroyuki・OHSHIMA, Takashi
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pd触媒によるアリル化を活用した1位四置換2,2,2-トリフルオロエチルアミン類の合成法の開発2018

    • Author(s)
      森本浩之、森崎一宏、近藤優太、澤真尚、大嶋孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する触媒的脱炭酸的不斉マンニッヒ型反応の開発2018

    • Author(s)
      澤真尚、宮崎翔太郎、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Lewis酸触媒によるチオノエステルとDAシクロプロパンの[3+2]環化付加反応2018

    • Author(s)
      中武大貴、松本洋平、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-アミノキノリンアミドの直接的触媒的加アルコール分解反応の開発2018

    • Author(s)
      出口亨、辛海龍、森本浩之、大嶋孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒドラジドの触媒的ワンポットエステル化反応の開発2018

    • Author(s)
      久保 友梨香、森本 浩之、大嶋 孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2018

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Direct Catalytic Asymmetric Addition of Various Nucleophiles to N-Unprotected Ketimines2017

    • Author(s)
      Ohshima Takashi
    • Organizer
      International Symposium on Green Chemistry 2017 (ISGC-2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Mild and Selective Oxidative Heck Reaction to Derivatize Complex Molecules and Reactivity Study of Heteroarenes2017

    • Author(s)
      Das Amrita, Takumi Kimijima, Kenji Watanabe, Makoto Tsuda, Takashi Ohshima
    • Organizer
      International Symposium on Green Chemistry 2017 (ISGC-2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素上無保護のケチミンに対する直接的触媒的不斉Mannich反応の開発2017

    • Author(s)
      澤真尚、森崎一宏、近藤優太、森本浩之、大嶋孝志
    • Organizer
      第15回次世代を担う有機化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する直接的触媒的不斉Mannich反応の開発2017

    • Author(s)
      澤真尚、森崎一宏、近藤優太、森本浩之、大嶋孝志
    • Organizer
      第27回万有福岡シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 温和な条件下でのアミド結合切断および形成反応の開発2017

    • Author(s)
      森本浩之、清水悠平、野下めぐみ、藤原理沙、大嶋孝志
    • Organizer
      第111回有機合成シンポジウム2017年【春】
    • Related Report
      2017 Annual Research Report
  • [Presentation] Catalytic Hydroxy Group-selective Conjugate Addition of Unprotected Amino Alcohols2017

    • Author(s)
      Zhao Li, Ryo Yazaki, Takashi Ohshima
    • Organizer
      第111回有機合成シンポジウム2017年【春】
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規BINOLリン酸触媒を用いた窒素上無保護のα-ケチミノエステルに対する直接的触媒的不斉Friedel-Craftsアルキル化反応の開発2017

    • Author(s)
      米嵜 凌平、近藤 優太、澤 真尚、森崎 一宏、森本 浩之、大嶋 孝志
    • Organizer
      第111回有機合成シンポジウム2017年【春】
    • Related Report
      2017 Annual Research Report
  • [Presentation] Direct Catalytic Asymmetric Addition to N-Unprotected Ketimines2017

    • Author(s)
      Takashi Ohshima
    • Organizer
      International Symposium on Pure & Applied Chemistry (ISPAC) 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Direct Catalytic Asymmetric Addition of Various Nucleophiles to N-Unprotected Ketimines2017

    • Author(s)
      Takashi Ohshima
    • Organizer
      The 19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS19)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chemo- and Regioselective Catalytic Conjugate Addition of Hydroxy Group over Amino Group2017

    • Author(s)
      Zhao Li, Ryo Yazaki, Takashi Ohshima
    • Organizer
      The 19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS19)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 窒素上無保護のケチミンに対する直接的触媒的不斉Mannich反応の開発2017

    • Author(s)
      澤真尚、森崎一宏、近藤優太、森本浩之、大嶋孝志
    • Organizer
      第29回万有札幌シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides2017

    • Author(s)
      Hai-Long Xin, Toru Deguchi, Hiroyuki Morimoto, and Takashi Ohshima
    • Organizer
      第54回化学関連支部合同九州大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規BINOL リン酸触媒を用いた窒素上無保護のα-ケチミノエステルに対する直接的触媒的不斉Friedel-Crafts アルキル化反応の開発2017

    • Author(s)
      米嵜凌平、近藤優太、澤真尚、森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第54回化学関連支部合同九州大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エステル等価体の触媒的酸化的α-ベンジル化反応の開発2017

    • Author(s)
      田中津久志、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第54回化学関連支部合同九州大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel C1-Symmetric BINOL Phosphoric Acid-Catalyzed Direct Catalytic Enantioselective Friedel-Crafts Alkylation to N-Unprotected α-Ketiminoester2017

    • Author(s)
      Ryohei Yonesaki, Yuta Kondo, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      29th The International Symposium on Chirality (Chirality2017; ISCD-29)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct Catalytic Asymmetric Mannich-type Reaction of N-Unprotected Ketimines2017

    • Author(s)
      Masanao Sawa, Kazuhiro Morisaki, Yuta Kondo, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      8th International Conference on Green and Sustainable Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Environmentally Friendly Ester Synthesis Reactions Catalyzed by Developed Zinc Catalysts2017

    • Author(s)
      Daiki Nakatake,Yuki Yokote,Yoshimasa Matsushima, Ryo Yazaki, Takashi Ohshima
    • Organizer
      8th International Conference on Green and Sustainable Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リサイクル可能な亜鉛担持固相触媒によるエステル交換反応2017

    • Author(s)
      中武大貴, 矢崎亮, 松嶋義正, 大嶋孝志
    • Organizer
      日本プロセス化学会2017サマーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-アミノキノリンアミドの直接的触媒的加アルコール分解反応の開発2017

    • Author(s)
      出口亨、辛海龍、森本浩之、大嶋孝志
    • Organizer
      第50回有機金属若手の会夏の学校
    • Related Report
      2017 Annual Research Report
  • [Presentation] エステル等価体の触媒的酸化的α-ベンジル化反応の開発2017

    • Author(s)
      田中 津久志、橋口 佳代子、田中 尊書、矢崎 亮、大嶋 孝志
    • Organizer
      第50回有機金属若手の会夏の学校
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規BINOL リン酸触媒を用いた窒素上無保護のα-ケチミノエステルに対する直接的触媒的不斉Friedel-Crafts アルキル化反応の開発2017

    • Author(s)
      近藤優太、米嵜凌平、澤真尚、森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第29回若手研究者のためのセミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] エステル等価体の触媒的酸化的α-アルキル化反応の開発2017

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第29回若手研究者のためのセミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] Hydrazine and Diethylenetriamine Mediated Direct Cleavage of Unactivated Amides, Carbamates, and Ureas2017

    • Author(s)
      Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      254nd American Chemical Society National Meeting & Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New Zinc and Iron Catalysts for Transesterification2017

    • Author(s)
      Takashi Ohshima
    • Organizer
      World Chemistry Conference & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catalytic chemoselective oxidative cross-enolate coupling Reaction2017

    • Author(s)
      Ryo Yazaki, Takafumi Tanaka, Tsukushi Tanaka and Takashi Ohshima
    • Organizer
      第64回有機金属化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-アミノキノリンアミドの直接的触媒的加アルコール分解反応の開発2017

    • Author(s)
      出口亨、辛海龍、森本浩之、大嶋孝志
    • Organizer
      第64回有機金属化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Boronic Acid-Accelerated Multicomponent Reactions for the Synthesis of α- Substituted Indole-3-acetic Acids2017

    • Author(s)
      Amrita Das, Kenji Watanabe, Hiroyuki Morimoto, and Takashi Ohshima
    • Organizer
      第64回有機金属化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 改良型亜鉛触媒によるエステル交換反応2017

    • Author(s)
      中武大貴、横手友紀、松嶋義正、矢崎亮、大嶋孝志
    • Organizer
      第34回有機合成化学セミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規BINOL リン酸触媒を用いた窒素上無保護のα-ケチミノエステルに対する直接的触媒的不斉Friedel-Crafts アルキル化反応の開発2017

    • Author(s)
      近藤優太、米嵜凌平、澤真尚、森崎一宏、森本浩之、大嶋孝志
    • Organizer
      第34回有機合成化学セミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] ベンジル位チオール化反応を用いたpH応答性生体共役反応2017

    • Author(s)
      渡辺賢司、大嶋孝志
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規キラルリン酸触媒による窒素上無保護α-ケチミノエステルへの直接的不斉Friedel-Crafts反応の開発2017

    • Author(s)
      米嵜 凌平、近藤 優太、Akkad Walaa、澤 真尚、森崎 一宏、森本 浩之、大嶋 孝志
    • Organizer
      第47回複素環化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ベンジル位チオール化反応を用いたpH応答性生体共役反応2017

    • Author(s)
      渡辺賢司、大嶋孝志
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-アミノキノリンアミドの直接的触媒的加アルコール分解反応の開発2017

    • Author(s)
      出口亨、辛海龍、森本浩之、大嶋孝志
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸素雰囲気下におけるアシルピラゾールの触媒的化学選択的α位酸化反応の開発2017

    • Author(s)
      谷之口誠也、矢崎亮、大嶋孝志
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Direct Catalytic Alcoholysis of 8-Aminoquinoline Amides2017

    • Author(s)
      Hai-Long Xin, Toru Deguchi, Hiroyuki Morimoto, Takashi Ohshima
    • Organizer
      第34回 日本薬学会九州支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カルボン酸等価体の触媒的酸化的α-ベンジル化反応2017

    • Author(s)
      田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志
    • Organizer
      第34回 日本薬学会九州支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ホモカップリング体形成を活用したエノラートの触媒的酸化的クロスカップリング反応の開発2017

    • Author(s)
      田中尊書、田中津久志、矢崎亮、大嶋孝志
    • Organizer
      第112回有機合成シンポジウム 2017年【秋】
    • Related Report
      2017 Annual Research Report
  • [Book] Heterocycles via Cross Dehydrogenative Coupling2019

    • Author(s)
      Yazaki, R.; Ohshima, T.
    • Total Pages
      494
    • Publisher
      Springer
    • Related Report
      2019 Annual Research Report
  • [Book] Tetranuclear Zinc Cluster-Catalyzed Transesterification in New Horizons of Process Chemistry2017

    • Author(s)
      Ohshima, Takashi
    • Publisher
      Springer, Singapore
    • Related Report
      2017 Annual Research Report
  • [Book] 銅触媒によるカルボン酸等価体のα位官能基化反応の開発2017

    • Author(s)
      大嶋孝志
    • Publisher
      JETI
    • Related Report
      2017 Annual Research Report
  • [Remarks] 九州大学大学院薬学研究院 環境調和創薬化学分野

    • URL

      http://green.phar.kyushu-u.ac.jp

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 九州大学先生の森

    • URL

      https://www.kyushu-u.ac.jp/ja/university/professor/oshima.html

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] ピラゾール誘導体及び医薬組成物2020

    • Inventor(s)
      10.白澤専二、角田俊之、大嶋孝志、矢崎亮、末永正彦
    • Industrial Property Rights Holder
      10.白澤専二、角田俊之、大嶋孝志、矢崎亮、末永正彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-017307
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 窒素上無保護イミン化合物の製造方法2019

    • Inventor(s)
      大嶋孝志、森本浩 之、森崎一宏、近藤 優太
    • Industrial Property Rights Holder
      大嶋孝志、森本浩 之、森崎一宏、近藤 優太
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 窒素上無保護イミン化合物の合成方法2018

    • Inventor(s)
      大嶋孝志、森本浩之、森崎一宏、近藤優太
    • Industrial Property Rights Holder
      大嶋孝志、森本浩之、森崎一宏、近藤優太
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-082703
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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