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Physico-chemical and mathematical analyses of immune related signal induced by antibody aggregates

Research Project

Project/Area Number 17H03975
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionOsaka University

Principal Investigator

Uchiyama Susumu  大阪大学, 工学研究科, 教授 (90335381)

Co-Investigator(Kenkyū-buntansha) 保仙 直毅  大阪大学, 医学系研究科, 教授 (10456923)
大戸 梅治  東京大学, 大学院薬学系研究科(薬学部), 准教授 (90451856)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywordsバイオ医薬 / 抗体医薬 / 安定性 / 凝集 / タンパク質 / 界面 / 免疫原性 / 分析 / バイオ医薬品 / 蛋白質 / 凝集体 / 質量分析 / 立体構造 / 抗体 / 免疫複合体 / TNF / 超遠心分析 / 沈降速度法 / 生体分子 / 薬学 / シグナル伝達 / バイオテクノロジー
Outline of Final Research Achievements

Based on this research, quantitative assessment of protein aggregates in biopharmaceuticals are established, and factors influencing protein aggregation as well as relation of immunological impact of protein aggregates were clarified. Specifically impact of protein-silicone oil drop released from syringe barrel protein complex on immune system is significant thus design of container is important. This study also indicate that interface stability of proteins are of importance to suppress protein aggregation, besides colloidal and conformational stabilities that have been pointed out as important factors for protein stability in solution. Based on this study,minimizing physical stress like vibration and impact should be a clue to stabilize therapeutic proteins in solution.

Academic Significance and Societal Importance of the Research Achievements

本研究は、近年、利用されているバイオ医薬品の安定性と安全性に関するものであるが、これまで不明点が多かったタンパク質凝集体と副作用の関係を実験的に示唆することができた社会的意義の大きい研究成果である。特に、製薬企業から医療現場で利用される実際の場面へとフィードバックが可能な知見が数多く含まれており、かつ、応急処置的な対応では無く、包括的かつ根本的に医薬品の安定性を高めることが可能となることから、科学的意義は当然ながら、産業的意義が大きいといえる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (62 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (6 results) Journal Article (25 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 24 results,  Open Access: 13 results,  Acknowledgement Compliant: 1 results) Presentation (30 results) (of which Int'l Joint Research: 14 results,  Invited: 27 results) Book (1 results)

  • [Int'l Joint Research] Ludwig-Maximilians-Universit Munchen/Philipps University of Marburg(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Ateneo University(フィリピン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] NIST/University of Colorado/Saint Louis University(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Federal University of Sao Paulo(ブラジル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Montreal(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Ludwig-Maximilians-Universit Munchen(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Critical analysis of techniques and materials used in devices, syringes, and needles used for intravitreal injections2020

    • Author(s)
      Melo Gustavo Barreto、Cruz Natasha Ferreira Santos da、Emerson Geoffrey Guy、Rezende Flavio Atanazio、Meyer Carsten H.、Uchiyama Susumu、Carpenter John、Shiroma Helio Francisco、Farah Michel Eid、Maia Mauricio、Rodrigues Eduardo Buchele
    • Journal Title

      Progress in Retinal and Eye Research

      Volume: in press Pages: 100862-100862

    • DOI

      10.1016/j.preteyeres.2020.100862

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of UVC Irradiation on the Oxidation of Histidine in Monoclonal Antibodies2020

    • Author(s)
      Miyahara Yuya, Shintani Koya, Hayashihara-Kakuhou Kayoko, Zukawa Takehiro, Morita Yukihiro, Nakazawa Takashi, Yoshida Takuya, Ohkubo Tadayasu, Uchiyama Susumu
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-020-63078-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stirring rate affects thermodynamics and unfolding kinetics in isothermal titration calorimetry2020

    • Author(s)
      Maruno Takahiro、Ohkubo Tadayasu、Uchiyama Susumu
    • Journal Title

      The Journal of Biochemistry

      Volume: 3 Issue: 1 Pages: 1-10

    • DOI

      10.1093/jb/mvaa028

    • NAID

      40022279168

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent Achievements and Current Interests in Research on the Characterization and Quality Control of Biopharmaceuticals in Japan2020

    • Author(s)
      Ishii-Watabe Akiko、Shibata Hiroko、Suetomo Hiroyuki、Ikeda Yosuke、Telikepalli Srivalli、Kiyoshi Masato、Hayashi Yu、Muto Takashi、Tanaka Yukako、Ueda Satomi、Iwura Takafumi、Saitoh Satoshi、Aoyama Michihiko、Harazono Akira、Hyuga Masashi、Goda Yukihiro、Torisu Tetsuo、Uchiyama Susumu
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 109 Issue: 5 Pages: 1652-1661

    • DOI

      10.1016/j.xphs.2020.01.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Automatic Identification of the Stress Sources of Protein Aggregates Using Flow Imaging Microscopy Images2020

    • Author(s)
      Gambe-Gilbuena Arni、Shibano Yuriko、Krayukhina Elena、Torisu Tetsuo、Uchiyama Susumu
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 109 Issue: 1 Pages: 614-623

    • DOI

      10.1016/j.xphs.2019.10.034

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relation of Colloidal and Conformational Stabilities to Aggregate Formation in a Monoclonal Antibody2020

    • Author(s)
      Oyama Hiroaki、Koga Hiroki、Tadokoro Takashi、Maenaka Katsumi、Shiota Akira、Yokoyama Masami、Noda Masanori、Torisu Tetsuo、Uchiyama Susumu
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 109 Issue: 1 Pages: 308-315

    • DOI

      10.1016/j.xphs.2019.10.038

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of the Injection Performance of a Tapered Needle for Use in Prefilled Biopharmaceutical Products2020

    • Author(s)
      Krayukhina Elena、Fukuhara Ayano、Uchiyama Susumu
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 109 Issue: 1 Pages: 515-523

    • DOI

      10.1016/j.xphs.2019.10.033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Fab portion of immunoglobulin G contributes to its binding to Fcγ receptor III.2019

    • Author(s)
      [Rina Yogo,Yuki Yamaguchi,Hiroki Watanabe,Hirokazu Yagi,Tadashi Satoh,Mahito Nakanishi,Masayoshi Onitsuka,Takeshi Omasa,Mari Shimada,Takahiro Maruno,Tetsuo Torisu,Shio Watanabe,Daisuke Higo,Takayuki Uchihashi,Saeko Yanaka,Susumu Uchiyama,Koichi Kato]
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 11957-11957

    • DOI

      10.1038/s41598-019-48323-w

    • NAID

      120006875664

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of IgG1 Aggregation Initiation Region by Hydrogen Deuterium Mass Spectrometry2019

    • Author(s)
      Noda Masanori、Ishii Kentaro、Yamauchi Mika、Oyama Hiroaki、Tadokoro Takashi、Maenaka Katsumi、Torisu Tetsuo、Uchiyama Susumu
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 108 Issue: 7 Pages: 2323-2333

    • DOI

      10.1016/j.xphs.2019.02.023

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Assessment of the Ability of Submicron- and Micron-Size Silicone Oil Droplets in Dropped Prefillable Syringes to Invoke Early- and Late-Stage Immune Responses2019

    • Author(s)
      Krayukhina Elena、Yokoyama Masami、Hayashihara Kayoko Kakuhou、Maruno Takahiro、Noda Masanori、Watanabe Hiroki、Uchihashi Takayuki、Uchiyama Susumu
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 108 Issue: 7 Pages: 2278-2287

    • DOI

      10.1016/j.xphs.2019.02.002

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] バイオ医薬品のタンパク質分散に使用される界面活性剤2019

    • Author(s)
      米田早紀、内山 進
    • Journal Title

      界面活性剤の選び方、使い方 事例集

      Volume: 7 Pages: 327-330

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Collaborative Study for Analysis of Subvisible Particles Using Flow Imaging and Light Obscuration: Experiences in Japanese Biopharmaceutical Consortium2019

    • Author(s)
      Kiyoshi Masato、Shibata Hiroko、Uchiyama Susumu、Ishii-Watabe Akiko
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 108 Issue: 2 Pages: 832-841

    • DOI

      10.1016/j.xphs.2018.08.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interlaboratory comparison about feasibility of insoluble particulate matter test for injections with reduced test volume in light obscuration method2019

    • Author(s)
      Harazono Akira、Shibata Hiroko、Kiyoshi Masato、Muto Takashi、Fukuda Jun、Torisu Tetsuo、Saitoh Satoshi、Nishimura Hirotaka、Uchiyama Susumu、Ishii-Watabe Akiko
    • Journal Title

      Biologicals

      Volume: 57 Pages: 46-49

    • DOI

      10.1016/j.biologicals.2018.12.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Laser Diffraction for Quantification of Protein Aggregates: Comparison With Resonant Mass Measurement, Nanoparticle Tracking Analysis, Flow Imaging, and Light Obscuration2019

    • Author(s)
      Yoneda Saki、Niederleitner Bertram、Wiggenhorn Michael、Koga Hiroki、Totoki Shinichiro、Krayukhina Elena、Friess Wolfgang、Uchiyama Susumu
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 108 Issue: 1 Pages: 755-762

    • DOI

      10.1016/j.xphs.2018.09.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toward the Proper Biophysical Characterization of Aggregates in Biopharmaceuticals2018

    • Author(s)
      Uchiyama Susumu
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 138 Issue: 12 Pages: 1503-1507

    • DOI

      10.1248/yakushi.18-00020-4

    • NAID

      130007539088

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2018-12-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current Trends in Analytical Technologies Which Promote the Development of Biopharmaceuticals2018

    • Author(s)
      Ishii-Watabe Akiko、Uchiyama Susumu
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 138 Issue: 12 Pages: 1473-1474

    • DOI

      10.1248/yakushi.18-00020-F

    • NAID

      130007539051

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2018-12-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sweeping of Adsorbed Therapeutic Protein on Prefillable Syringes Promotes Micron Aggregate Generation2018

    • Author(s)
      Maruno Takahiro、Watanabe Hiroki、Yoneda Saki、Uchihashi Takayuki、Adachi Satoru、Arai Kunihito、Sawaguchi Taichi、Uchiyama Susumu
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 印刷中 Issue: 6 Pages: 1521-1529

    • DOI

      10.1016/j.xphs.2018.01.021

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physicochemical improvement of rabbit derived single-domain antibodies by substitutions with amino acids conserved in camelid antibodies2018

    • Author(s)
      Shinozaki Naoya、Hashimoto Ryuji、Noda Masanori、Uchiyama Susumu
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 125 Issue: 6 Pages: 654-661

    • DOI

      10.1016/j.jbiosc.2018.01.006

    • NAID

      210000005719

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Native mass spectrometry for understanding dynamic protein complex2018

    • Author(s)
      Ishii Kentaro、Zhou Min、Uchiyama Susumu
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1862 Issue: 2 Pages: 275-286

    • DOI

      10.1016/j.bbagen.2017.09.019

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analytical ultracentrifugation with fluorescence detection 1 system reveals differences in complex formation between recombinant human TNFα and different biological TNFα antagonists in various environments.2017

    • Author(s)
      Krayukhina, E., Noda, M., Ishii, K., Maruno, T., Wakabayashi, H., Tada, M., Suzuki, T., Ishii-Watabe, A., Kato, M., Uchiyama, S.
    • Journal Title

      mabs

      Volume: 9 Issue: 4 Pages: 664-679

    • DOI

      10.1080/19420862.2017.1297909

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities2017

    • Author(s)
      Shinozaki Naoya、Hashimoto Ryuji、Fukui Kiichi、Uchiyama Susumu
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 5794-5794

    • DOI

      10.1038/s41598-017-06277-x

    • NAID

      120006995024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NMR Detection of Semi-Specific Antibody Interactions in Serum Environments2017

    • Author(s)
      Yanaka Saeko、Yamazaki Toshio、Yogo Rina、Noda Masanori、Uchiyama Susumu、Yagi Hirokazu、Kato Koichi
    • Journal Title

      Molecules

      Volume: 22 Issue: 10 Pages: 1619-1619

    • DOI

      10.3390/molecules22101619

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Friability Testing as a New Stress-Stability Assay for Biopharmaceuticals2017

    • Author(s)
      Torisu Tetsuo、Maruno Takahiro、Yoneda Saki、Hamaji Yoshinori、Honda Shinya、Ohkubo Tadayasu、Uchiyama Susumu
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 106 Issue: 10 Pages: 2966-2978

    • DOI

      10.1016/j.xphs.2017.05.035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sedimentation velocity analytical ultracentrifugation for characterization of therapeutic antibodies2017

    • Author(s)
      Uchiyama Susumu、Noda Masanori、Krayukhina Elena
    • Journal Title

      Biophysical Reviews

      Volume: 10 Issue: 2 Pages: 259-269

    • DOI

      10.1007/s12551-017-0374-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent Topics of Research in the Characterization and Quality Control of Biopharmaceuticals in Japan2017

    • Author(s)
      Ishii-Watabe Akiko、Shibata Hiroko、Harazono Akira、Hyuga Masashi、Kiyoshi Masato、Saitoh Satoshi、Iwura Takafumi、Torisu Tetsuo、Goda Yukihiro、Uchiyama Susumu
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 106 Issue: 12 Pages: 3431-3437

    • DOI

      10.1016/j.xphs.2017.07.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Hydrogen/deuterium exchange mass spectrometry analysis of therapeutic IgG molecules2020

    • Author(s)
      Susumu Uchiyama
    • Organizer
      Keystone symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Affinity of protein-protein and protein-ligand interactions analyzed by native mass spectrometry2019

    • Author(s)
      内山 進
    • Organizer
      第67回質量分析総合討論会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Relation between stability and structural changes of an antibody in different formulations2019

    • Author(s)
      Hiroaki Oyama, Masanori Noda, Tetsuo Torisu, Susumu Uchiyama
    • Organizer
      HDXMS2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural analysis of IgG Fc region in Fc fragment and IgG1 fullbody2019

    • Author(s)
      Yuki Yamaguchi, Tetsuo Torisu, Susumu Uchiyama
    • Organizer
      HDXMS2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] バイオ医薬品の品質低下と防止について2019

    • Author(s)
      内山 進
    • Organizer
      日本医療薬学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Formulation and primary packaging optimizations for biopharmaceuticals in prefilled syringes2019

    • Author(s)
      Susumu Uchiyama
    • Organizer
      PDA Europe
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Formulation and container closure system strategies for biopharmaceuticals with higher stability2019

    • Author(s)
      Susumu Uchiyama
    • Organizer
      Antibody-based Therapeutics & BioProduction Forum
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural Assessment of Therapeutic Antibody by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)2019

    • Author(s)
      Susumu Uchiyama
    • Organizer
      Antibody-based Therapeutics & BioProduction Forum
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stirring rate affects thermodynamic and kinetic reactions in isothermal titration calorimetry2019

    • Author(s)
      Susumu Uchiyama
    • Organizer
      CALCON2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemistry, Manufacturing, and Control of Biopharmaceuticals2019

    • Author(s)
      Susumu Uchiyama
    • Organizer
      2019 JSGCT
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Total design of biopharmaceuticals with high quality and safety2019

    • Author(s)
      Susumu Uchiyama
    • Organizer
      AASP2019@Suwon
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 蛋白質科学と規制科学からみるバイオ医薬品の現状と課題2019

    • Author(s)
      内山 進
    • Organizer
      蛋白質科学会・細胞生物学会合同年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Factors influencing Quality of Biopharmaceuticals in Pre-filled Syringes2019

    • Author(s)
      Susumu Uchiyama
    • Organizer
      FDA workshop
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Formulation and container closure system strategies for biopharmaceuticals with higher stability2019

    • Author(s)
      Susumu Uchiyama
    • Organizer
      2019Peptalk Protein Aggregation and Emerging Analytical Tools conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Aggregates quantification in wide range of size using orthogonal methods2019

    • Author(s)
      Susumu Uchiyama
    • Organizer
      Biotherapeutics Analytical Summit
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] PDA Europe2019

    • Author(s)
      Susumu Uchiyama
    • Organizer
      Factors influencing Quality of Biopharmaceuticals in Pre-filled Syringes
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] バイオ医薬品に求められる プレフィルドシリンジの特性2018

    • Author(s)
      内山 進
    • Organizer
      PDA プレフィルドシリンジセミナー2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] バイオ医薬品の物性解析2018

    • Author(s)
      内山 進
    • Organizer
      第39回JAACTシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Comparison of light obscuration and flow imaging analyses of protein particles induced by various stresses2018

    • Author(s)
      Susumu Uchiyama
    • Organizer
      Colorado protein stability and immunogenicity
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Causes of protein aggregates generation in biopharmaceuticals2018

    • Author(s)
      Susumu Uchiyama
    • Organizer
      FDA internal seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Causes of protein aggregates generation in biopharmaceuticals2018

    • Author(s)
      Susumu Uchiyama
    • Organizer
      JAACT Tsukuba
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 抗体医薬の物理化学と スマートフォーミュレーション2018

    • Author(s)
      内山 進
    • Organizer
      第10回GFRGプロジェクトシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 蛋白質医薬溶液のトータルな最適化2017

    • Author(s)
      内山 進
    • Organizer
      第17回蛋白質科学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 質量分析による抗体医薬と抗原の相互作用解析2017

    • Author(s)
      石井健太郎,丸野孝浩 、岡本優太 、野田 勝紀、内山 進
    • Organizer
      質量分析討論会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Biophysical analytical methods for biotechnology2017

    • Author(s)
      Susumu Uchiyama
    • Organizer
      第20回台湾生物物理学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Factors affecting stabilities of biopharmaceuticals in prefilled syringe2017

    • Author(s)
      Susumu Uchiyama
    • Organizer
      Prefilled syringe Seminar 2017 Tokyo
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Biophysical characterizations of antibody drugs by mass spectrometry2017

    • Author(s)
      Susumu Uchiyama
    • Organizer
      Korean Society for Mass Spectrometry Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Analytical ultracentrifugation for biopharmaceuticals characterizations and formulation development2017

    • Author(s)
      Susumu Uchiyama
    • Organizer
      Symposium and Workshop for analytical ultracentrifugation, Beijing
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 蛍光超遠心分析による抗体医薬の希薄濃度・生体類似環境での相互作用解析2017

    • Author(s)
      内山 進
    • Organizer
      BMIAフォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Biophysical characterizations of biopharmaceuticals2017

    • Author(s)
      Susumu Uchiyama
    • Organizer
      台湾交通大学特別セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] バイオ医薬(石井明子、川西徹、長野哲雄編)2020

    • Author(s)
      鳥巣哲生、内山 進(分担執筆)
    • Publisher
      東京化学同人
    • ISBN
      9784807909810
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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