Metabolism and functions of novel phospholipids
| Project/Area Number |
17H03980
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo Medical and Dental University (2019)
Akita University (2017-2018) |
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Principal Investigator |
Sasaki Takehiko 東京医科歯科大学, 難治疾患研究所, 教授 (50333365)
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| Co-Investigator(Kenkyū-buntansha) |
高須賀 俊輔 秋田大学, 医学系研究科, 助教 (90375262)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 細胞膜 / リン脂質 / 質量分析 / 病態モデルマウス / 病態モデル / 脂質 / キナーゼ / ホスファターゼ / がん / シグナル伝達 |
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| Outline of Final Research Achievements |
We promoted research to elucidate the dynamics, metabolic mechanism, and physiological functions of the novel phospholipids we have discovered. Mass spectrometry of samples from various species revealed its widespread presence in eukaryotes. Biochemical and molecular biology techniques have been used to identify the enzymes that regulate their metabolism, and some have been identified as disease-causing gene products. Furthermore, by utilizing pathological model mice, changes in the novel lipids associated with the disease were clarified.
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| Academic Significance and Societal Importance of the Research Achievements |
新規脂質の動態、代謝機構と生理機能を解明する研究を推進し、新しい研究分野の開拓につながる知見を世界に先駆けて得ることができた。これらが種々の疾患で特有の変動することが見出されたことから、薬物開発の新しい治療標的の提示、疾患バイオマーカーとしての活用の礎となることが期待できる。
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] PIKfyve regulates melanosome biogenesis2018
Author(s)
Liggins Marc C.、Flesher Jessica L.、Jahid Sohail、Vasudeva Priya、Eby Victoria、Takasuga Shunsuke、Sasaki Junko、Sasaki Takehiko、Boissy Raymond E.、Ganesan Anand K.
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Journal Title
PLOS Genetics
Volume: 14
Issue: 3
Pages: e1007290-e1007290
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K2017
Author(s)
Malek M、Kielkowska A、Chessa T、Anderson K E.、Barneda D、Pir P、Nakanishi H、Eguchi S、Koizumi A、Sasaki J、Juvin V、Kiselev VY.、Niewczas I、Gray A、Valayer A、Spensberger D、Imbert M、Felisbino S、Habuchi T、Beinke S、Cosulich S、Le Novere N、Sasaki T、Clark J、Hawkins PT.、Stephens LR.
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Journal Title
Molecular Cell
Volume: 68
Issue: 3
Pages: 566-580
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.2017
Author(s)
Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H.
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Journal Title
Sci Rep.
Volume: 7
Issue: 7
Pages: 45050-45050
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.2017
Author(s)
Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T
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Journal Title
JCI Insight
Volume: 2
Issue: 1
Pages: 89462-89478
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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