| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Organs including the liver are grown and maintained at an appropriate size through cell proliferation. Elucidation of the molecular mechanism that controls the size and quality of organs is an important issue both in Japan and abroad. From the isolation and analysis of medaka mutants, we showed that the transcriptional co-activator YAP plays an essential role in 3D organogenesis via cell tension, and that activated YAP-expressing canine kidney epithelial cells (MDCK) induces pressure on adjacent cells and extrusion of YAP-expressing cells to the apical surface. In this study, we found that 1) YAP-dependent elimination of impaired hepatocytes in mouse livers, and 2) an essential role of prostaglandin E2 in YAP-dependent MDCK elimination.
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