| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
In recent years, it has been found that there are many genes encoding multidrug efflux transporters in the bacterial genome. In this study, we analyze the role of transporters and their regulatory networks in multidrug resistance, and clarify the substrate recognition and transport mechanism of these transporters. It was found that transporter was induced by the components of the fatty acid, and the induction of this expression was dependent on RamR, a repressor of activator RamA. By using multiple entry pathways, drug efflux pumps have been found to recognize and transport multiple drugs with different physicochemical properties. A compound that inhibit the ABC-type drug efflux transporter MacAB was obtained.
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