Search for seed molecules for development of new antitumor drugs from plant alkaloids
| Project/Area Number |
17H03993
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Natural medicines
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
KITAJIMA Mariko 千葉大学, 大学院薬学研究院, 准教授 (60195261)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
|---|
| Keywords | 天然活性物質 / 生物活性物質の探索 / アルカロイド / 化学合成 / 構造解析 / 全合成 |
|---|
| Outline of Final Research Achievements |
Total synthesis of gelsedine-type Gelsemium alkaloids which have cytotoxic activity toward human cancer cell lines were carried out and asymmetric total synthesis of seven alkaloids was accomplished. New alkaloids were isolated from medicinal plant resources. New cyclic tetrapeptide was isolated from Ophiorrhiza plant and its asymmetric total synthesis was accomplished. Some cyclic tetrapeptide derivatives possessing cytotoxicity toward human cancer cell lines were obtained via the structure－activity relationship study.
|
| Academic Significance and Societal Importance of the Research Achievements |
がんの罹患数やがんによる死亡数は増加し続けており、新たな抗がん剤の開発が望まれている。本研究では、薬用資源植物からの新規抗腫瘍性アルカロイドの探索、天然アルカロイド類の全合成、誘導体合成、活性評価を実施し、ヒト腫瘍細胞毒性作用を有する化合物や新規天然アルカロイド類の取得、詳細な活性評価に向けた微量アルカロイド類の不斉全合成を達成した。今後、これらアルカロイドの活性評価、構造活性相関研究等を通して新規抗腫瘍薬開発に向けたシード分子の取得が期待できる。
|
Report
(4 results)
Research Products
(63 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Biphenyl Ether and Biphenyl Quinolizidine Lactone Alkaloids from Heimia salicifolia.2018
Author(s)
M. Kitajima, T. Yanagisawa, M. Tsukahara, Y. Yamaguchi, N. Kogure, R. Kikura-Hanajiri, Y. Goda, O. Iida, Y. Sugimura, N. Kawahara, and H. Takayama
-
Journal Title
Tetrahedron
Volume: 74
Issue: 4
Pages: 441-452
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] キョウチクトウ科 Kopsia arborea 含有新規インドールアルカロイド Kopsiyunnanines K, L, M の構造と Andranginine の絶対立体配置2017
Author(s)
小暮紀行, 徳田涼子, 通山紫乃, 中澤麻衣子, 小山徹也, 岡本佳樹, 三森雄二, Yuqui Wu, Rong-Ping Zhang, 北島満里子, 高山廣光
Organizer
第59回天然有機化合物討論会
Related Report
-
-
-
-
-
-
