| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
From the perspective of periodic table of elements in medicinal chemistry, structure-property relationships and structure-activity relationships of a series of multi-elemental organic compounds were systematically investigated. Structural development using a wide variety of multi-elemental compounds including silyl functionalities, phosphorus functionalities, and ferrocene were investigated to clarify the utility of these chemical species. Novel and unique ligands for androgen receptor, estrogen receptor, and progesterone receptor were developed, and novel applications of the multi-elemental species in medicinal chemistry were proposed.
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