| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
We developed efficient synthetic methods for optically active small-ring size alpha,alpha-disubstituted alpha-amino acids, and analyzed the secondary structure of their peptides. Chiral centers at the side-chain of small-ring size amino acid homopeptides controlled their helical-screw directions on a case-by-case basis. Using cyclic alpha,alpha-disubstituted alpha-amino acids-containing arginine-based peptides, pDNAs could be efficiently introduced into cells. Cyclic alpha,alpha-disubstituted alpha-amino acids-containing helical peptides catalyzed enantioselective 1,4-addition reaction of cyclic enones, and also helical peptides with an N-terminal thiourea moiety catalyzed highly enantioselective 1,4-addition reactions between nitroalkenes and dialkyl malonates.
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