| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
We have already identified a novel tetravalent peptide, PVF-tet, which binds to hemagglutinin (HA) of type A influenza viruses (IAVs) and efficiently inhibits the virus propagation. PVF-tet was found to bind to newly synthesized HA, rather than to the HA of the parental virus and then induce the formation of lamella body-like structure to accumulate the HA in it. In this study, we found that this structure is the inducible amphisome, whose formation is induced by the activation of the autophagic pathway. Importantly, a dynamic change of the cellular phospholipid metabolism was found to be involved in its formation. Our findings are providing a new strategy to regulate the IAV infection by regulating the cellular phospholipid metabolism.
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