| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Outline of Final Research Achievements |
This research aimed to clarify whether human liver chimeric mice and their isolated hepatocytes can be used as a novel system for the quantitative prediction of human hepatic clearance of drugs. As a result, in vivo hepatic intrinsic clearance in humans could be well predicted from uptake clearance of drugs estimated with various batches of hepatocytes isolated from chimeric mice. Biliary excretion clearance of drugs in sandwich cultured hepatocytes from various batches of chimeric mice can also be observed. Moreover, in vivo biliary excretion clearance in chimeric mice is well correlated with human biliary excretion clearance. Thus, this experimental system with chimeric mice is very useful to mimic hepatobiliary transport of drugs in humans.
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