| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
We have found that zinc transporter ZIP10 is essential for epithelial formation in mice, and its possible involvement in atopic dermatitis. We also demonstrated that ZIP14 is involved in pathophysiology of cancer cachexia. In addition, we found that zinc deficiency abrogates epigenetics that results in blocking the keratinocyte differentiation. Recently, we have developed the series of mice in which EGFP was inserted in promoter of several zinc transporters, which will be useful to investigate the roles of zinc signals in physiology and pathophysiology. We are currently investigating the involvement of each zinc transporters in cancers by using these mice.
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