| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Intracellular organelles are involved in the regulation of a variety of cellular functions through the interactions with other organelles, in addition to their own functions. However, the molecular mechanism that links cell physiological functions to interorganelle interactions has yet to be analyzed. In this study, we show that the mitochondrial outer membrane protein voltage-dependent anion channel 2 (VDAC2), which was identified as a regulator of endocytosis for signaling from the small G protein Ras and its target molecule phosphoinositide 3-kinase (PI3K), governs the mitochondria-endosome interaction and subsequent endosome maturation.
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