| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
It is thought that environmental factors such as intestinal microflora and diet play critical roles in the development of inflammatory bowel disease. However, it is little known as to what kind of environmental factors are involved in this disease and how these factors affect the intestinal homeostasis. We observed that more proteins are ubiquitinated in the large intestine of germ free mice than in that of specific pathogen free mice. We showed that mass spectrometric analysis enables comprehensive identification of ubiquitinated proteins in the colon. We also found that oral administration of D-serine, not L-serine, has a preventive and therapeutic effect in a naive T cell transfer model of chronic colitis.
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