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Elucidation of physiological significance of newly discovered CRH release pathway and its relationship with known HPA axis

Research Project

Project/Area Number 17H04025
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

FUKUDA Atsuo  浜松医科大学, 医学部, 教授 (50254272)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywords摂食 / 室傍核 / AgRP / CRH / 弓状核 / 正中隆起 / GABA / NKCC1 / HPA Axis / HPA axis
Outline of Final Research Achievements

The identification and physiological significance of the cell subtypes of the novel CRH release pathway were clarified using AgRP cell-selective (arcuate nucleus) and CRH cell-selective (paraventricular nucleus) genetically modified mice. Blood corticosterone levels were measured in undernutrition stress model and the difference from pharmacogenetic stimulation of AgRP cells was evaluated. As a result, pharmacogenetic stimulation of the entire AgRP cells activated CRH cells in the paraventricular nucleus. Undernutrition also activated a part of AgRP cells but not CRH cells. Serum corticosterone increased in both cases. From the above, we elucidated the mechanism by which a part of AgRP cell population in the arcuate nucleus respond to malnutrition, which increases the activity of the novel HPA axis at median eminence and causes CRH secretion.

Academic Significance and Societal Importance of the Research Achievements

GABAはCRH 細胞の反応を室傍核(細胞体)で抑制、正中隆起(軸索終末)で促進し、相反的にCRH 放出を制御すると考えられている (Kakizawa, Sci Adv 2016)。今回我々は弓状核のAgRP陽性GABA 細胞のうち一部の集団のみが低栄養に反応して正中隆起からのCRH放出を起こすことを突き止めた(低栄養による新規HPA 軸選択的活性化)。すなわち、肉体的・精神的ストレスでの既知HPA軸の活性化とは異なる経路を介して、低栄養状態に対してストレス応答することを見出したことは学術的・社会的に意義がある。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (126 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (8 results) Journal Article (17 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 14 results,  Open Access: 12 results) Presentation (93 results) (of which Int'l Joint Research: 30 results,  Invited: 15 results) Book (4 results) Remarks (4 results)

  • [Int'l Joint Research] Yale School of Medicine(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] マインツ大学(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Yale School of Medicine(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] マインツ大学(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Yale School of Medicine(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] マインツ大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Yale School of Medicine(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] マインツ大学(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] GABAA receptors and maternally derived taurine regulate the temporal specification of progenitors of excitatory glutamatergic neurons in the mouse developing cortex.2021

    • Author(s)
      Tochitani S, Furukawa T, Bando R, Kondo S, Ito T, Matsushima Y, Kojima T, Matsuzaki H, Fukuda A.
    • Journal Title

      Cerebral Cortex

      Volume: In press Pages: 4554-4575

    • DOI

      10.1093/cercor/bhab106

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice2021

    • Author(s)
      Aoto K, Kato M, Akita T, Nakashima M, Mutoh H, Akasaka N, Tohyama J, Nomura Y, Hoshino K, Ago Y, Tanaka R, Epstein O, Ben-Haim R, Heyman E, Miyazaki T, Belal H, Takabayashi S, Ohba C, Takata A, Mizuguchi T, Miyatake S, Miyake N, Fukuda A, Matsumoto N and Saitsu H
    • Journal Title

      Nat Commun

      Volume: 12 Issue: 1 Pages: 2107-2107

    • DOI

      10.1038/s41467-021-22389-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intracellular Cl- dysregulation causing and caused by pathogenic neuronal activity.2020

    • Author(s)
      Akita T, Fukuda A
    • Journal Title

      Pflugers Archiv - European Journal of Physiology

      Volume: - Issue: 7 Pages: 977-987

    • DOI

      10.1007/s00424-020-02375-4

    • NAID

      120007026259

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Can we understand human brain development from experimental studies in rodents?2020

    • Author(s)
      Luhmann Heiko J.、Fukuda Atsuo
    • Journal Title

      Pediatrics International

      Volume: 62 Issue: 10 Pages: 1139-1144

    • DOI

      10.1111/ped.14339

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 背側縫線核ニューロンに対する覚醒ペプチドオレキシンのダイナミッククランプ研究.2020

    • Author(s)
      石橋賢, 福田敦夫, Leonard CS.
    • Journal Title

      細胞

      Volume: 52 Pages: 50-53

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 細胞発振から集団発振へのモーダルシフトにおけるCl-‐GABAシステムの関わり.2020

    • Author(s)
      福田敦夫.
    • Journal Title

      BRAIN and NERVE

      Volume: 72 Pages: 1127-1134

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 神経回路発振におけるGABAシナプスとアストロサイトの役割.2020

    • Author(s)
      福田敦夫.
    • Journal Title

      脳神経内科

      Volume: 93 Pages: 433-440

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Chloride homeodynamics underlying modal shifts in cellular and network oscillations2020

    • Author(s)
      Fukuda Atsuo
    • Journal Title

      Neuroscience Research

      Volume: In press Pages: 14-23

    • DOI

      10.1016/j.neures.2020.02.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.2019

    • Author(s)
      Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT.
    • Journal Title

      Science Signaling

      Volume: 12 Issue: 603

    • DOI

      10.1126/scisignal.aaw9315

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diverse Actions of Astrocytes in GABAergic Signaling.2019

    • Author(s)
      Masaru Ishibashi, Kiyoshi Egawa, Atsuo Fukuda
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20(12) Issue: 12 Pages: 1-18

    • DOI

      10.3390/ijms20122964

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic potential of human SLC12A5 variants causing KCC2 dysfunction.2019

    • Author(s)
      Fukuda A and Watanabe M
    • Journal Title

      Brain Research

      Volume: 1710 Pages: 1-7

    • DOI

      10.1016/j.brainres.2018.12.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alterations of GABAergic Neuron-Associated Extracellular Matrix and Synaptic Responses in Gad1-Heterozygous Mice Subjected to Prenatal Stress2018

    • Author(s)
      Wang T, Sinha AS, Akita T, Yanagawa Y, Fukuda A
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 12 Pages: 284-284

    • DOI

      10.3389/fncel.2018.00284

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MHC class I in dopaminergic neurons suppresses relapse to reward seeking2018

    • Author(s)
      Murakami G, Edamura M, Furukawa T, Kawasaki H, Kosugi I, Fukuda A, Iwashita T, Nakahara D
    • Journal Title

      Science Advances

      Volume: 4 Issue: 3 Pages: 7388-7388

    • DOI

      10.1126/sciadv.aap7388

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optical measurement of glutamate in slice preparations of the mouse retina2018

    • Author(s)
      M. Ohkuma, M. Kaneda, S. Yoshida, A. Fukuda, E. Miyachi
    • Journal Title

      Neuroscience Research

      Volume: 印刷中 Pages: 30544-8

    • DOI

      10.1016/j.neures.2018.03.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biallelic Variants in CNPY3 , Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy2018

    • Author(s)
      Mutoh Hiroki、Kato Mitsuhiro、Akita Tenpei、Shibata Takuma、Wakamoto Hiroyuki、Ikeda Hiroko、Kitaura Hiroki、Aoto Kazushi、Nakashima Mitsuko、Wang Tianying、Ohba Chihiro、Miyatake Satoko、Miyake Noriko、Kakita Akiyoshi、Miyake Kensuke、Fukuda Atsuo、Matsumoto Naomichi、Saitsu Hirotomo
    • Journal Title

      The American Journal of Human Genetics

      Volume: 102 Issue: 2 Pages: 321-329

    • DOI

      10.1016/j.ajhg.2018.01.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders2018

    • Author(s)
      Akita Tenpei、Aoto Kazushi、Kato Mitsuhiro、Shiina Masaaki、Mutoh Hiroki、Nakashima Mitsuko、Kuki Ichiro、Okazaki Shin、Magara Shinichi、Shiihara Takashi、Yokochi Kenji、Aiba Kaori、Tohyama Jun、Ohba Chihiro、Miyatake Satoko、Miyake Noriko、Ogata Kazuhiro、Fukuda Atsuo、Matsumoto Naomichi、Saitsu Hirotomo
    • Journal Title

      Annals of Clinical and Translational Neurology

      Volume: 5 Issue: 3 Pages: 280-296

    • DOI

      10.1002/acn3.528

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Taurine as an Essential Neuromodulator during Perinatal Cortical Development2017

    • Author(s)
      Kilb W, Fukuda A.
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 11:328 Pages: 328-328

    • DOI

      10.3389/fncel.2017.00328

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Voltage-sensitive Na+ and K+ current components in interneuron precursors in the medial ganglionic eminence of the embryonic cerebrum.2021

    • Author(s)
      Akita T, Fukuda A.
    • Organizer
      第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Developmentally regulated KCC2 phosphorylation is critical for dynamic GABA-mediated inhibition.2021

    • Author(s)
      Watanabe M, Kahle KT, Fukuda A.
    • Organizer
      第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胎児期・生後発達期のタウリン枯渇は大脳皮質錐体神経の発火応答を鈍麻させる.2021

    • Author(s)
      秋田天平, 細井泰志, 渡部美穂, 伊藤崇志, 宮嶋裕明, 福田敦夫.
    • Organizer
      第7回国際タウリン研究会日本部会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 神経細胞内タウリンによるリン酸化を介したGABAA受容体発現制御機構.2021

    • Author(s)
      渡部美穂, 細井泰志, 秋田天平, 伊藤崇志, 福田敦夫.
    • Organizer
      第7回国際タウリン研究会日本部会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 発達期皮質錐体細胞におけるCa2+動態とタウリンによるGABAA受容体活性化.2021

    • Author(s)
      石橋賢, 阪東勇輝, 佐藤康二, 福田敦夫.
    • Organizer
      第7回国際タウリン研究会日本部会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 神経連続発火活動低下を伴うてんかん性脳症発症機序の解明を目指して.2020

    • Author(s)
      秋田天平, 青戸一司, 才津浩智, 北野勝則, 福田敦夫.
    • Organizer
      第47回日本脳科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 背側縫線核セロトニン作動性ニューロンにおけるオレキシン誘発性発火後過分極がシナプス入力感受性に及ぼす影響.2020

    • Author(s)
      石橋賢, 福田敦夫, Leonard CS.
    • Organizer
      第47回日本脳科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] リン酸化によるカリウム-クロライド共輸送体(KCC2)の機能制御はGABAによる抑制性伝達形成に必須である.2020

    • Author(s)
      渡部美穂, Kahle KT, 福田敦夫.
    • Organizer
      第47回日本脳科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Gad1ヘテロ欠損と胎生期ストレスの二重ヒットによりエピジェネティックに惹起される神経発生・分化の運命転化.2020

    • Author(s)
      王天英, Sinha AS, 柳川右千夫, 河合智子, 秦健一郎, 福田敦夫.
    • Organizer
      第47回日本脳科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Prenatal stress on Gad1 insufficient fetuses enhances tonic inhibition in medial prefrontal cortex by increasing excitability of GABA neurons.2020

    • Author(s)
      Fukuda A, Wang T, Sinha AS, Akita T, Yanagawa Y.
    • Organizer
      The 23rd Annual Meeting of the Korean Society for Brain and Neural Sciences (KSBNS)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胎生脳内側基底核原基の神経前駆細胞における2種類の電位依存性陽イオン電流の発見.2020

    • Author(s)
      秋田天平, 福田敦夫.
    • Organizer
      第67回中部日本生理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] カリウム-クロライド共役担体(KCC2)のリン酸化による機能制御.2020

    • Author(s)
      渡部美穂, Kahle KT, 福田敦夫.
    • Organizer
      第67回中部日本生理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 発達期皮質錐体細胞におけるCa2+動態とタウリンによるGABAA受容体活性化.2020

    • Author(s)
      石橋賢,阪東勇輝, 佐藤康二, 福田敦夫.
    • Organizer
      第67回中部日本生理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Identification of the GABAergic projections from arcuate nucleus involved in modulation of the CRH release.2020

    • Author(s)
      Yesmin R, Watanabe M, Wang T, Sinha AS, Akita T, Ishibashi M, Fukuda A.
    • Organizer
      第67回中部日本生理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Gad1 heterozygotes subjected to prenatal stress undergo epigenetic dysregulation of genes perturbing neurodevelopment and behavior.2020

    • Author(s)
      Sinha AS, Wang T, Mutoh H, Akita T, Yanagawa Y, Kawai T, Hata K, Fukuda A.
    • Organizer
      第67回中部日本生理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Prenatal stress on Gad1 insufficient fetuses drastically change GABA transmission in the medial prefrontal cortex.2020

    • Author(s)
      Fukuda A.
    • Organizer
      KSBMB International Conference 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pivotal roles of neuronal excitation-inhibition dynamics in epileptogenesis of human and animal models.2020

    • Author(s)
      Fukuda A.
    • Organizer
      The 21st Annual Meeting of the Infantile Seizure Society (ISS)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Two cation current components in GABAergic interneuron precursors in the medial ganglionic eminence of the embryonic brain.2020

    • Author(s)
      Akita T, Fukuda A.
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.2020

    • Author(s)
      Watanabe M, Kahle KT, Fukuda A.
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Orexin receptor activation induces a novel slow afterhyperpolarization that results from the calciumdependentclosure of cation channels in serotonergic dorsal raphe neurons.2020

    • Author(s)
      Ishibashi M, Fukuda A, Leonard CS.
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] WNK3 kinase maintains basal excitability by regulating inward rectification and intracellular chloride in layer V pyramidal neurons of mouse medial prefrontal cortex.2020

    • Author(s)
      Sinha AS, Wang T, Hosoi Y, Sohara E, Akita T, Uchida S, Fukuda A.
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Gad1ヘテロ欠損と胎生期ストレスの二重ヒットはエピジェネティックに統合失調症モデルフェノタイプを誘導する.2020

    • Author(s)
      福田敦夫.
    • Organizer
      自然科学研究機構分野融合型共同研究事業 ワークショップ「運動・行動から紐解く脳神経回路発達メカニズムの異分野融合研究による解明」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 発達期のCRHニューロン制御機構におけるGABAの役割.2020

    • Author(s)
      渡部美穂, 柿沢圭亮, 福田敦夫.
    • Organizer
      自然科学研究機構分野融合型共同研究事業 ワークショップ「運動・行動から紐解く脳神経回路発達メカニズムの異分野融合研究による解明」
    • Related Report
      2019 Annual Research Report
  • [Presentation] 発達期皮質錐体細胞におけるCa2+動態とタウリンによるGABAA受容体活性化.2020

    • Author(s)
      石橋賢, 阪東勇輝, 佐藤康二, 福田敦夫.
    • Organizer
      自然科学研究機構分野融合型共同研究事業 ワークショップ「運動・行動から紐解く脳神経回路発達メカニズムの異分野融合研究による解明」
    • Related Report
      2019 Annual Research Report
  • [Presentation] Gad1 heterozygotes subjected to prenatal stress undergo epigenetic dysregulation of genes perturbing neurodevelopment altering inhibitory network and behavior.2020

    • Author(s)
      Sinha AS, Wang T, Mutoh H, Akita T, Yanagawa Y, Kawai T, Hata K, Fukuda A.
    • Organizer
      自然科学研究機構分野融合型共同研究事業 ワークショップ「運動・行動から紐解く脳神経回路発達メカニズムの異分野融合研究による解明」
    • Related Report
      2019 Annual Research Report
  • [Presentation] Gad1と出生前ストレスの二重ヒットはエピジェネティックに発達障害を惹起する.2020

    • Author(s)
      福田敦夫.
    • Organizer
      群馬大学セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Mutations and posttranslational modulations of the K+-Cl- cotransporter underlie seizures and epilepsy.2019

    • Author(s)
      Fukuda A.
    • Organizer
      AuPS/ASB Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Astrocytes signaling to control GABA inhibition.2019

    • Author(s)
      Fukuda A.
    • Organizer
      Neuroscience/Epilepsy Mini Symposium in UNSW
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Static magnetic fields decrease excitability of pyramidal neurons by increasing membrane Cl- conductance in the mouse motor cortex.2019

    • Author(s)
      Sinha AS, Takamatsu Y, Akita T, Mima T, Fukuda A.
    • Organizer
      Neural Oscillation Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 背側縫線核セロトニン作動性ニューロンおけるオレキシン誘発性発火後過分極と内向き電流に対する細胞内外カルシウム濃度の影響.2019

    • Author(s)
      石橋賢, 福田敦夫 , Leonard S Christopher.
    • Organizer
      第46回日本脳科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Static magnetic fields reduce excitability of pyramidal neurons by increasing membrane Cl- conductance in the mouse motor cortex.2019

    • Author(s)
      Sinha AS、高松泰行, 秋田天平, 美馬達哉, 福田敦夫.
    • Organizer
      第46回日本脳科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Gad1 heterozygotes subjected to prenatal stress undergo epigenetic dysregulation of genes perturbing neurodevelopment and behavioral phenotypes.2019

    • Author(s)
      Wang T, Sinha Adya S, Mutoh H, Akita T, Yanagawa Y, Kawai T, Hata K, Fukuda A.
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Excitatory gabaergic inputs to GnRH neurons are required for female reproduction.2019

    • Author(s)
      Watanabe M, Fukuda A.
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of a novel slow afterhyperpolarization (sAHP) on spike encoding by serotonergic (5-HT) dorsal raphe (DR) neurons.2019

    • Author(s)
      Ishibashi, M, Berry EA, Molina NE, Sato T, Fukuda A, Leonard CS.
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pivotal roles of Cl-homeostasis in epileptogenesis of human and animal models.2019

    • Author(s)
      Fukuda A.
    • Organizer
      6th Congress of AsCNP
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胎生期大脳基底核原基の神経前駆細胞に生じる膜電流成分について.2019

    • Author(s)
      秋田天平, 福田敦夫.
    • Organizer
      第66回中部日本生理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抑制性神経伝達を維持するカリウム-クロライド共役担体(KCC2)のリン酸化による制御の役割.2019

    • Author(s)
      渡部美穂, Kahle KT, 福田敦夫.
    • Organizer
      第66回中部日本生理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 背側縫線核セロトニン作動性ニューロンにおけるオレキシン誘発性発火後過分極と内向き電流に対する細胞内外カルシウム濃度の影響.2019

    • Author(s)
      石橋賢, 福田敦夫 , Leonard S Christopher.
    • Organizer
      第66回中部日本生理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A KCC2 phospho-switch is essential for dynamic GABA-mediated inhibition and postnatal survival.2019

    • Author(s)
      Watanabe M, Zhang J, Mansuri M, Duan J, Kahle KT, Fukuda A.
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Static magnetic fields reduce excitability of pyramidal neurons by enhancing membrane Cl- conductance in the mouse motor cortex.2019

    • Author(s)
      Sinha Adya S, Takamatsu Y, Akita T, Mima T, Fukuda A.
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Prenatal stress to the Gad1 heterozygotes causes epigenetic changes in neurodevelopment and behavior relating genes and affects their phenotypes.2019

    • Author(s)
      Wang T, Sinha AS, Mutoh H, Akita T, Yanagawa Y, Kawai T, Hata K, Fukuda A.
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effect of orexin on the firing pattern of serotonergic dorsal raphe neurons.2019

    • Author(s)
      Ishibashi M, Fukuda A, Leonard CS.
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Prenatal stress to the Gad1 heterozygotes induces neurodevelopmental disorder-like phenotypes along with epigenetic changes in relating genes.2019

    • Author(s)
      Fukuda A
    • Organizer
      2019 International Meeting on Brain Research and Pharmaceutical Science (IMBRP)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cl- homeodynamics and multimodal GABA actions underlying neurological and psychiatric diseases.2019

    • Author(s)
      Fukuda A.
    • Organizer
      Guilin medical university special lecture
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human epilepsy and animal model with mutations in KCC2.2019

    • Author(s)
      Fukuda A.
    • Organizer
      9th FAOPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ca2+ signaling and ion channel activation in embryonic neurons in the medial ganglionic eminence.2019

    • Author(s)
      Akita T, Fukuda A.
    • Organizer
      9th FAOPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Developmental regulation of KCC2 phosphorylation is essential for GABA signaling and survival.2019

    • Author(s)
      Watanabe M. Zhang J, Mansuri M, Duan J, Kahle KT, Fukuda A.
    • Organizer
      9th FAOPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of orexin on the firing pattern of serotonergic dorsal raphe neurons.2019

    • Author(s)
      Ishibashi M, Molina NE, Fukuda A.
    • Organizer
      9th FAOPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prenatal stress on Gad1-heterozygotes perturbs development of GABAergic networks affecting behavior.2019

    • Author(s)
      Wang T, Sinha AS, Mutoh H, Akita T, Yanagawa Y, Kawai T, Hata K, Fukuda A.
    • Organizer
      9th FAOPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisms underlying WNK3 kinase mediated regulation of neuronal excitability in prefrontal cortex.2019

    • Author(s)
      Sinha AS, Wang T, Hosoi Y, Sohara E, Akita T, Uchida S, Fukuda A.
    • Organizer
      9th FAOPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CRH release regulation by GABAergic projection from arcuate nucleus using chemogenetic model.2019

    • Author(s)
      Yesmin R, Watanabe M, Fukuda A.
    • Organizer
      9th FAOPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gad1-heterozygotes subjected to prenatal stress undergo alterations in extracellular matrix associated with GABAergic neuron and inhibitory synaptic transmission.2019

    • Author(s)
      Sinha AS, Wang T, Akita T, Yanagawa Y, Fukuda A.
    • Organizer
      第25回浜松医科学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞内タウリンによるPKC基質部位リン酸化を介したGABAA受容体膜移行維持機構.2019

    • Author(s)
      細井泰志, 渡部美穂, 秋田天平, 伊藤崇志, 福田敦夫.
    • Organizer
      第5回国際タウリン研究会日本部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胎生期大脳基底核原基の神経前駆細胞内Ca2+シグナリングについて.2018

    • Author(s)
      秋田天平, 福田敦夫.
    • Organizer
      第65回中部日本生理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] GABAによる抑制性伝達におけるカリウム-クロライド共役担体(KCC2)のリン酸化による機能制御の役割.2018

    • Author(s)
      渡部美穂, Zhang J, Mansuri M, Duan J, Kahle KT, 福田敦夫.
    • Organizer
      第65回中部日本生理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 背側縫線核セロトニン作動性ニューロンにおけるオレキシン誘発性の発火後過分極増強と内向き電流への細胞外カルシウムの影響.2018

    • Author(s)
      石橋賢, Molina NE, 福田敦夫, Leonard CS.
    • Organizer
      第65回中部日本生理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Alterations of GABAergic Neuron-Associated Extracellular Matrix and Synaptic Responses in Gad1-Heterozygous Mice Subjected to Prenatal Stress.2018

    • Author(s)
      Sinha AS, Wang T, Mutoh H, Akita T, Yanagawa Y, Fukuda A.
    • Organizer
      第65回中部日本生理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of chemogenetic model to study physiological roles of the GABAergic projection from arcuate nucleus to the CRH nerve terminals.2018

    • Author(s)
      Yesmin R, Watanabe M, Fukuda A.
    • Organizer
      第65回中部日本生理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of orexin on the firing pattern of serotonergic dorsal raphe neurons.2018

    • Author(s)
      Ishibashi M, Molina NE, Fukuda A, Leonard CS.
    • Organizer
      第45回日本脳科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] てんかんにおけるGABAシナプスの役割.2018

    • Author(s)
      福田敦夫.
    • Organizer
      第61回日本脳循環代謝学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Prenatal stress to the GAD67 heterozygous mice impairs GABA neurogenesis followed by physiological dysfunctions in postnatal life.2018

    • Author(s)
      Fukuda A.
    • Organizer
      第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Prenatal stress on Gad1-heterozygotes selectively perturbs GABAergic neurogenesis, GABAergic synapse function and behavioral phenotypes.2018

    • Author(s)
      Wang T, Sinha AS, Mutoh H, Akita T, Yanagawa Y, Kawai T, Hata K, Fukuda A.
    • Organizer
      第7回日本DOHaD学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cl-ホメオダイナミクスとマルチモーダルGABA:脳での多彩な働き.2018

    • Author(s)
      福田敦夫.
    • Organizer
      第65回脳の医学・生物学研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] WNK3 Kinase regulates inwardly rectifying potassium channels in layer V pyramidal neurons of the mouse prefrontal cortex.2018

    • Author(s)
      Sinha AS, Hosoi Y, Sohara E, Mutoh H, Akita T, Uchida S, Fukuda A.
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prenatal stress on Gad1-heterozygotes selectively perturbs GABAergic neurogenesis, GABAergic synapse function and behavioral phenotypes.2018

    • Author(s)
      Wang T, Sinha AS, Mutoh H, Akita T, Yanagawa Y, Kawai T, Hata K, Fukuda A.
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] De novo mutants of CaMKIIα/β responsible for neurodevelopmental disorders upregulate A-type voltage-dependent K+ currents in hippocampal neurons.2018

    • Author(s)
      Akita T, Aoto K, Kato M, Shiina M, Mutoh H, Nakashima M, Kuki I, Okazaki S, Magara S, Shiihara T, Yokochi K, Aiba K, Tohyama J, Ohba C, Miyatake S, Miyake N, Ogata K, Fukuda A, Matsumoto N, Saitsu H.
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Regulated Phosphorylation of KCC2 at Thr906/Thr1007 is essential for activity-dependent Cl-extrusion during normal brain development.2018

    • Author(s)
      Fukuda, A.
    • Organizer
      FENS forum 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経・精神疾患の病因・病態仮説としてのマルチモーダル GABA.2018

    • Author(s)
      福田敦夫.
    • Organizer
      お茶の水ニューロサイエンスセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Maternal taurine modulate fetal brain development via intracellular and extracellular effectors.2018

    • Author(s)
      Fukuda, A.
    • Organizer
      The 21st International Taurine Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diverse Actions of Astrocytes at GABAergic Tripartite Synapses in Seizures: Are they protective or exacerbative?2018

    • Author(s)
      Fukuda, A.
    • Organizer
      2018 Symposium on Functional Interactions among Glia and Neurons
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] De novo CaMKⅡα/β mutants causing neurodevelopmental disorders upregulate A-type voltage-dependent K+ currents in hippocampal neurons.2018

    • Author(s)
      Akita T, Aoto K, Fukuda A, Matsumoto N, Saitsu H.
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] WNK3 kinase regulates inwardly rectifying potassium current in layer V pyramidal neurons of the mouse prefrontal cortex.2018

    • Author(s)
      Sinha Adya S, Hosoi Y, Sohara E, Mutoh H, Akita T, Uchida S, Fukuda A.
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Temporally genetic expression of KCC2 in GnRH neurons in vivo causes impairment of fertility.2018

    • Author(s)
      Watanabe M, Nabekura J, Fukuda A.
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] タウリン欠乏はGABAA受容体のリン酸化状態を変化させることにより大脳皮質感覚野錐体細胞におけるポストシナプスのGABAA受容体数を減少させる.2018

    • Author(s)
      細井泰志, 渡部美穂, 秋田天平, 武藤弘樹, 伊藤崇志, 福田敦夫.
    • Organizer
      第4回国際タウリン研究会日本部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The role of GABAergic interneuron-astrocyte interaction in epileptic seizures.2018

    • Author(s)
      Mutoh, H., Fukuda, A.
    • Organizer
      第1回山梨大学先端脳科学特別教育プログラム国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GABA synaptic dynamics and astrocytic Cl- buffering underlying neural network oscillation.2017

    • Author(s)
      福田敦夫.
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A novel CRH secretory mechanism by an excitatory GABAergic input from the arcuate nucleus to the median eminence.2017

    • Author(s)
      Fukuda, A.
    • Organizer
      The 17th Hamamatsu-Kyungpook Joint Medical Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of inwardly rectifying potassium current by WNK3 kinase in layer V pyramidal neurons of the mouse prefrontal cortex.2017

    • Author(s)
      Sinha Adya, S., Hosoi, Y., Sohara, E., Mutoh, H., Akita, T., Uchida, S., Fukuda, A.
    • Organizer
      The 17th Hamamatsu-Kyungpook Joint Medical Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prenatal stress on Gad1-heterozygotes perturbs GABAergic neurogenesis, GABAergic synapse formation and behavioral phenotypes.2017

    • Author(s)
      Fukuda, A. Wang, T., Sinha Adya, S., Yanagawa, Y., Kawai, T. and Hata, K.
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Constitutive phosphomimetic inhibition of KCC2 at Thr906/Thr1007 causes GABA-dependent network excitability, seizure, and early postnatal death.2017

    • Author(s)
      Watanabe, M., Duan, J., Mansuri, M., Zhang, J., Fukuda, A. and Kahle, K.T.
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] KCC2 dysfunction underlying infantile and neonatal seizures in an animal model.2017

    • Author(s)
      福田敦夫, 渡部美穂, 秋田天平, Kahle, K.
    • Organizer
      第51回日本てんかん学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Prenatal stress on Gad1- heterozygotes affects inhibitory synaptic transmission.2017

    • Author(s)
      Wang, T., Sinha Adya, S., Akita, T., Yanagawa, Y., Fukuda, A.
    • Organizer
      生理学研究所研究会「シナプス・神経回路機能の時空間制御」
    • Related Report
      2017 Annual Research Report
  • [Presentation] Prenatal stress on Gad1-heterozygotes perturbs development of brain and behavior by epigenetic mechanism.2017

    • Author(s)
      Wang T, Sinha AS, Yanagawa Y, Kawai T, Hata K and Fukuda A.
    • Organizer
      第44回日本脳科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of inwardly rectifying potassium current by WNK3 kinase in layer V pyramidal neurons of the mouse prefrontal cortex.2017

    • Author(s)
      Sinha Adya, S., Hosoi, Y., Sohara, E., Mutoh, H., Akita, T., Uchida, S. and Fukuda, A.
    • Organizer
      第64回中部日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生殖腺刺激ホルモン放出ホルモン(GnRH)ニューロン制御における興奮性GABA入力の役割.2017

    • Author(s)
      渡部美穂, 鍋倉淳一, 福田敦夫.
    • Organizer
      第64回中部日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] てんかん原性獲得過程における抑制性神経とグリア細胞の相互作用.2017

    • Author(s)
      武藤弘樹, 福田敦夫.
    • Organizer
      第64回中部日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A novel CRH secretory mechanism by GABAergic input from the arcuate nucleus to the axon terminals of high [Cl-]i.2017

    • Author(s)
      Fukuda, A.
    • Organizer
      Seminar of Center for Neuron-Glia Interaction, KIST(Korea Institute of Science and Technology)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Taurine depletion reduces postsynaptic GABAA receptors in layer 2/3 pyramidal neurons of the somatosensory cortex.2017

    • Author(s)
      Hosoi, Y., Akita, T., Watanabe, M., Mutoh, H., Miyajima, H. and Fukuda, A.
    • Organizer
      XXIII World Congress of Neurology(WCN2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 母体ストレスとGABAが仔脳発達に与える病態生理学的影響.2017

    • Author(s)
      福田敦夫, 王天英, Sinha Adya S, 柳川右千夫, 河合智子, 秦健一郎.
    • Organizer
      第27回日本病態生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of inwardly rectifying potassium current by WNK3 kinase in layer V pyramidal neurons of the mouse prefrontal cortex.2017

    • Author(s)
      Sinha Adya, S., Hosoi,Y., Sohara, E., Mutoh, H., Akita, T., Uchida, S. and Fukuda, A.
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The role of GABAergic interneuron-astrocyte interaction in epileptic seizures.2017

    • Author(s)
      Mutoh, H., Fukuda, A.
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cellular Mechanisms Underlying Status Epilepticus: what do animal models tell us?2017

    • Author(s)
      Fukuda, A.
    • Organizer
      The 19th Annual Meeting of Infantile Seizure Society International Symposium on Status Epilepticus in Infants and Children
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Prenatal stress on Gad1-heterozygotes selectively perturbs parvalbumin (PV)-positive GABAergic neurogenesis, GABA synapses and social interaction behavior.2017

    • Author(s)
      Wang, T., Sinha Adya, S., Yanagawa, Y., Kawai, T., Hata, K. and Fukuda, A.
    • Organizer
      IBNS 26th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] Chloride Homeodynamics Underlying Pathogenic Modal Shifts of GABA Actions. Chapter 13. Comprehensive Developmental Neuroscience 2nd ed: Synapse Development and Maturation2020

    • Author(s)
      Fukuda A
    • Total Pages
      558
    • Publisher
      Academic Press
    • Related Report
      2020 Annual Research Report
  • [Book] Multimodal GABA receptor functions on cell development. Chapter 14. Comprehensive Developmental Neuroscience 2nd ed: Synapse Development and Maturation2020

    • Author(s)
      Kumada T. and Fukuda A.
    • Total Pages
      558
    • Publisher
      Academic Press
    • Related Report
      2020 Annual Research Report
  • [Book] Regulation of neuronal cell migration and cortical development by chloride transporter activities. Chapter 5. Neuronal Chloride Transporters in Health and Disease2020

    • Author(s)
      Akita T. and Fukuda, A.
    • Total Pages
      766
    • Publisher
      Academic Press
    • Related Report
      2020 Annual Research Report
  • [Book] Post-translational modification of neuronal chloride transporters. Chapter 11. Neuronal Chloride Transporters in Health and Disease2020

    • Author(s)
      Watanabe M. and Fukuda A
    • Total Pages
      766
    • Publisher
      Academic Press
    • Related Report
      2020 Annual Research Report
  • [Remarks] 浜松医科大学医学部神経生理学講座ホームページ

    • URL

      https://www.hama-med.ac.jp/education/fac-med/dept/neurophysiology/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 浜松医科大学プレスリリース「米国科学振興協会の科学雑誌に研究成果が公表されました」

    • URL

      https://www.hama-med.ac.jp/topics/2019/25433.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 日本生理学会ホームページ サイエンストピックス

    • URL

      http://physiology.jp/science-topic/22726/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 浜松医科大学医学部神経生理学講座ホームページ

    • URL

      http://www.hama-med.ac.jp/uni_education_igakubu_igaku_seiri1.html

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-05-23  

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