| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
We conducted this research project to dissect the mechanisms how RNA regulation contributes to cardiac homeostasis in physiological maintenance of heart functions and pathological conditions in heart failure. In physiological conditions, executor of RNA poly(A) degradation CCR4-NOT deadenylase complex was revealed to regulate stability of Atg7 mRNA and thereby maintain healthy cardiomyocytes. In the pathology of heart failure, a deadenylase factor was elucidated to induce cardiac remodeling and fibrosis through RNA regulation in cardiac fibroblasts, suggesting that RNA regulation is a potential target for treating heart failure. Furthermore, defined molecular mechanisms for RNA regulation in cardiac homeostasis were investigated with PAR-CLIP and other comprehensive RNA analyses with deep sequencing, and potential new targets for therapeutics were identified in this study.
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