| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Cognitive function in mouse models of schizophrenia was evaluated by a touchscreen-based visual discrimination (VD) test, a rational assay that can be performed by rodents and humans, in order to provide translational validity. Genetic mouse models of schizophrenia, including mouse carrying DISC1 deletion, schizophrenia-associated RELN or ARHGAP10 gene mutation, all exhibited impairments in the VD test, which was accompanied by an increase in c-Fos expression in the prefrontal cortex and dorsomedial striatum. We also demonstrated that mitogen-activated protein kinase signaling in the dopamine D1 receptor expressing-medium spiny neurons of the nucleus accumbens plays an important role in stimulus-reward learning. Through the comprehensive behavioral and neurochemical analyses of genetic mouse models of neuropsychiatric disorders we have identified several new targets for novel drug discovery and development.
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