| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
To develop infection control strategies, better understanding of the evolutionary processes of pathogens is essential. Shiga toxin (Stx)-producing Escherichia coli (STEC) and enteropathogenic E. coli (EPEC) are important human pathogens sharing cattle as the primary reservoir. Here, a large-scale genomic comparison of bovine and human commensal E. coli and clinical STEC and EPEC strains reveals that bovine commensal strains are phylogenetically distinct from human commensal strains and that the bovine-adapted lineage is serving as evolutionary sources of the emergence of STEC and EPEC. Identification of virulence gene communities each accumulated in STEC and EPEC suggests the presence of a selection pressure(s) to promote their accumulation in bovine intestine, which could be targets for developing efficient strategies to control these pathogens.
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