Validation on the possible zoonotic transmission by a novel colonization factor found on pandemic enterotoxigenic E. coli serogroup O169
| Project/Area Number |
17H04078
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中台 枝里子 (鹿毛枝里子) 大阪市立大学, 大学院生活科学研究科, 教授 (40453790)
山口 良弘 大阪市立大学, 大学院理学研究科, 准教授 (00737009)
立花 太郎 大阪市立大学, 大学院工学研究科, 教授 (80311752)
山崎 伸二 大阪府立大学, 生命環境科学研究科, 教授 (70221653)
増田 俊哉 大阪市立大学, 大学院生活科学研究科, 教授 (10219339)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | 腸管毒素原性大腸菌 / 下痢原性大腸菌 / 腸管定着因子 / 人獣共通感染症 / 接着因子 / ETEC / 宿主特異性 / 病原性 / 細菌 / 食品 / 下痢 |
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| Outline of Final Research Achievements |
In 1991, enterotoxigenic Escherichia coli (ETEC) serotype O169:H41 was found in a foodborne outbreak. The strain possessed genes for three kinds of colonization factors and showed aggregative adhesion to intestinal epithelial cells in vitro with one novel colonization factor. The putative adhesins were purified and provided as antigens for the seroepidemiological investigation. Swine sera reacting with the antigen were prevalent unexpectedly; ETEC that has the novel colonization factor could be an etiological agent of zoonosis.
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| Academic Significance and Societal Importance of the Research Achievements |
腸管毒素原性大腸菌（ETEC）はヒトのみならず、ウシやブタの下痢症原因菌でもあるが、それぞれの動物種にはそれぞれのETECがあり、ETECが種間を超えて人獣共通感染症をおこすことはないとされてきた。本研究は、ヒトのETECで最も検出頻度の高いO169がブタの腸上皮に付着するための遺伝子を保有し、ブタの多くがこの新規接着因子に対する抗体を血清中に保持していた。ETECには人獣共通感染症の原因になり得るものがあり、その対策をOne healthの概念の下で検討する必要があることが示された。
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Report
(2 results)
Research Products
(9 results)
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[Journal Article] Prevalence of Diarrheagenic <i>Escherichia coli</i> in Foods and Fecal Specimens Obtained from Cattle, Pigs, Chickens, Asymptomatic Carriers, and Patients in Osaka and Hyogo, Japan2017
Author(s)
95.Wang, L., Zhang, S., Zheng, D., Fujihara, S., Wakabayashi, A., Okahata, K., Suzuki, M., Saeki, A., Nakamura, H., Hara-Kudo, Y., Kage-Nakadai, E., and Nishikawa, Y.
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Journal Title
Japanese Journal of Infectious Diseases
Volume: 70
Issue: 4
Pages: 464-469
DOI
NAID
ISSN
1344-6304, 1884-2836
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Diffusely adherent Escherichia coli (DAEC) strains isolated from healthy carriers inhibit IL-8 secretion of epithelial cells by the type VI secretion system (T6SS)2017
Author(s)
Takeuchi, N., Tanimoto, Y., Tamai, S., Yanagida, S., Yamaguchi, Y., Kage-Nakadai, E., and Nishikawa, Y.
Organizer
The 16th Awaji International Forum on Infection and Immunity
Related Report
Int'l Joint Research
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