Molecular basis for the evasion of host immunity by mycobacteria
| Project/Area Number |
17H04087
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
Yamasaki Sho 大阪大学, 微生物病研究所, 教授 (40312946)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 抗酸菌 / 免疫抑制 / 免疫受容体 |
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| Outline of Final Research Achievements |
Mycobacteria-derived lipids recognized by inhibitory immunoreceptors were identified. When we analyzed anti-mycobacterial immune responses of macrophages and dendritic cells from receptor-deficient mice, the production of specific chemokines was selectively up-regulated. We compared the responses to infection between receptor-deficient and wild-type mice, and found that the deficient mice showed enhanced antigen-specific T-cell responses, suggesting that mycobacteria utilize this interaction to evade host immunity. In addition, we identified candidate receptors that recognize PGL. In order to replicate this human anti-mycobacterial responses in mice, we have established BAC transgenic mouse expressing human receptors.
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| Academic Significance and Societal Importance of the Research Achievements |
欠損マウスでは抗酸菌抗原特異的なT細胞応答が増強していることが判明し、結核菌が宿主免疫を回避する分子機構の一端が明らかとなったことにより、抗酸菌、中でもとりわけ近年増加している非定型性抗酸菌に対する治療戦略が広がると期待される。また、ヒトにおける抗酸菌応答をマウスで再現するため、ヒト受容体BACトランスジェニックマウスの樹立に成功したことにより、成人で有効性が低いBCGワクチンの問題点を改善できる可能性があり、より効果の高い結核ワクチンの開発への貢献が期待される。
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Report
(4 results)
Research Products
(115 results)
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[Journal Article] Dectin-2-mediated signaling triggered by the cell wall polysaccharides of Cryptcoccus neoformans2019
Author(s)
Daiki Tanno, Rin Yokoyama, Kotone Kawamura, Yuki Kitai, Xiaoliang Yuan, Keiko Ishii, Magdia De Jesus, Hideki Yamamoto, Ko Sato, Tomomitsu Miyasaka, Hiroki Shimura, Nobuyuki Shibata, Yoshiyuki Adachi, Naohito Ohno, Sho Yamasaki, Kazuyoshi Kawakami
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Journal Title
Microbiology and Immunology
Volume: 63
Issue: 12
Pages: 500-512
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The effect of MR1 ligand glycol-analogues on mucosal-associated invariant T (MAIT) cell activation.2019
Author(s)
Braganza, CD., Shibata, K., Fujiwara, A., Motozono, C., Sonoda, KH., Yamasaki, S., Stocker, BL., Timmer, MSM.
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Journal Title
Org Biomol Chem.
Volume: 17
Issue: 40
Pages: 8992-9000
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria2019
Author(s)
Reinink P, Buter J, Mishra VK, Ishikawa E, Cheng TY, Willemsen PTJ, Porwollik S, Brennan PJ, Heinz E, Mayfield JA, Dougan G, van Els CA, Cerundolo V, Napolitani G, Yamasaki S, Minnaard AJ, McClelland M, Moody DB, Van Rhijn I.
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Journal Title
The Journal of Experimental Medicine
Volume: 216
Issue: 4
Pages: 757-771
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice.2019
Author(s)
Asako Ishikawa, Yasunobu Miyake, Kimiko Kobayashi, Yuzo Murata, Sayaka Iizasa, Ei’ichi Iizasa, Sho Yamasaki, Naomi Hirakawa, Hiromitsu Hara, Hiroki Yoshida, Toshiharu Yasaka
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Journal Title
Scientific Reports
Volume: 9
Issue: 1
Pages: 872-872
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] High affinity sugar ligands of C-type lectin receptor langerin.2018
Author(s)
Ota F, Hirayama T, Kizuka Y, Yamaguchi Y, Fujinawa R, Nagata M; Ismanto HS, Lepenies, Aretz J, Rademacher C, Seeberger PH; Angata T, Kitazume S, Yoshida K, Betsuyaku T, Kida K Yamasaki S, and Taniguchi N
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Journal Title
BBA - General Subjects
Volume: -
Issue: 7
Pages: 1592-1601
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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