| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Mycobacteria-derived lipids recognized by inhibitory immunoreceptors were identified. When we analyzed anti-mycobacterial immune responses of macrophages and dendritic cells from receptor-deficient mice, the production of specific chemokines was selectively up-regulated. We compared the responses to infection between receptor-deficient and wild-type mice, and found that the deficient mice showed enhanced antigen-specific T-cell responses, suggesting that mycobacteria utilize this interaction to evade host immunity. In addition, we identified candidate receptors that recognize PGL. In order to replicate this human anti-mycobacterial responses in mice, we have established BAC transgenic mouse expressing human receptors.
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