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Real-time tumor-tracking arc therapy for stereotactic body radiotherapy

Research Project

Project/Area Number 17H04115
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionHokkaido University

Principal Investigator

Miyamoto Naoki  北海道大学, 工学研究院, 准教授 (00552879)

Co-Investigator(Kenkyū-buntansha) 鬼丸 力也  北海道大学, 医学研究院, 准教授 (80374461)
富岡 智  北海道大学, 工学研究院, 教授 (40237110)
鈴木 隆介  北海道大学, 大学病院, 助教 (00400052)
前田 憲一郎  北海道大学, 大学病院, 特任助教 (20790827)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Keywords動体追跡放射線治療 / 呼吸性移動対策 / 回転照射 / 体幹部定位照射 / 体内マーカ / 医学物理 / 動体追跡回転照射 / 体幹部定位
Outline of Final Research Achievements

In this study, we have developed the fundamental techniques to realize real-time tumor-tracking arc radiation therapy for stereotactic body radiation therapy. In order to show the clinical feasibility and effectiveness, expected treatment time and dosiemtric characteristics were evaluated. Treatment time could be reduced by the proposed treatment technique compared with the current treatment system used for real-time tumor-tracking. For the dosimetric validation, film and ion-chamber measurement with dynamic phantom was conducted. It was confirmed that the acceptable dosimetric characteristics could be achievable with the proposed technique. Dosimetric error between the measured dose and the planned dose was within 3% in ion-chamber measurement. It was suggested that the proposed method has clinical feasibility.

Academic Significance and Societal Importance of the Research Achievements

本研究の推進により、治療時間短縮と高精度な呼吸性移動対策を両立できる新しい体幹部定位放射線治療の基盤技術として、X線透視画像に混入する治療放射線の散乱線の除去や、一方向X線透視による腫瘍位置推定など、考案した新しいアイデアをもとにして、治療技術の実現性と有効性を確認することができた。また、今後も拡大することが予想される体幹部定位放射線治療において、患者にとって負担の少ない、かつ適切で安全な治療を提供できるようにすることにつながり、結果として、QOL(Quality Of Life) の向上に寄与できるものと思われるため、社会的意義も大きいと考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (16 results)

All 2020 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (14 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results)

  • [Journal Article] Dynamic gating window technique for the reduction of dosimetric error in respiratory-gated spot-scanning particle therapy: An initial phantom study using patient tumor trajectory data2020

    • Author(s)
      Naoki Miyamoto, Kouhei Yokokawa, Seishin Takao, Taeko Matsuura, Sodai Tanaka, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 1 Issue: 4 Pages: 1-9

    • DOI

      10.1002/acm2.12832

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative evaluation of image recognition performance of fiducial markers in real-time tumor-tracking radiation therapy2019

    • Author(s)
      Naoki Miyamoto, Kenichiro Maeda, Daisuke Abo, Ryo Morita, Seishin Takao, Taeko Matsuura, Norio Katoh, Kikuo Umegaki, Shinichi Shimizu, Hiroki Shirato
    • Journal Title

      Physica Medica

      Volume: 65 Pages: 33-39

    • DOI

      10.1016/j.ejmp.2019.08.004

    • NAID

      120006890334

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Image processing for removing contamination of scattered treatment beam to kV X-ray image in real-time tumor-tracking radiotherapy system2019

    • Author(s)
      Shin Nakashima, Naoki Miyamoto, Sodai Tanaka, Masaya Tamura, Ryusuke Suzuki
    • Organizer
      第118回医学物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A method for generating real-time X-ray images by utilizing 4D digital phantom2019

    • Author(s)
      Kousei Hamamuki, Naoki Miyamoto, Sodai Tanaka, Masaya Tamura, Ryusuke Suzuki
    • Organizer
      第118回医学物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Clinical feasibility evaluation of real-time tumor-tracking volumetric modulated arc therapy (RT-VMAT)2019

    • Author(s)
      Naoki Miyamoto, Ryusuke Suzuki, Sodai Tanaka, Masaya Tamura, Satoshi Tomioka, Hiroshi Taguchi, Norio Katoh, Rikiya Onimaru, Shinichi Shimizu, Hiroki Shirato
    • Organizer
      AAPM Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-time volumetric image generation with CT image deformation driven by displacement of internal fiducial markers2018

    • Author(s)
      Naoki Miyamoto, Naoki Matsumoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Takaaki Fujii, Shusuke Hirayama, Satoshi Tomioka, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    • Organizer
      2018 AAPM Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A robust tracking algorithm for implanted markers of fluoroscopic images in a real-time tumor-tracking system2018

    • Author(s)
      Koichi Miyazaki, Yusuke Fujii, Toru Umekawa, Takahiro Yamada, Takaaki Fujii, Naoki Miyamoto
    • Organizer
      2018 AAPM Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A study on the influence of changing the motion recognition rate on the dose accuracy of spot-scanning proton therapy2018

    • Author(s)
      Tetsuhiro Sodeta, Taeko Matsuura, Seishin Takao, Shusuke Hirayama, Takahiro Kanehira, Naoki Miyamoto, Kentaro Nishioka, Norio Kato, Kikuo Umegaki, Hiroki Shirato
    • Organizer
      2018 AAPM Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estimation of deformation vector field from the internal fiducial markers in lung2018

    • Author(s)
      Naoki Matsumoto, Naoki Miyamoto, Ayano Makinaga, Ryusuke Suzuki
    • Organizer
      第115回医学物理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Marker recognition algorithm based on image similarity using pixel value histogram in real-time tumor-tracking radiotherapy system2018

    • Author(s)
      Kazunori Matsuyama, Naoki Miyamoto, Ayano Makinaga, Ryusuke Suzuki
    • Organizer
      第115回医学物理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A study of quality evaluation in treatment plan of intensity modulated radiation therapy using the gradient measurement tool2018

    • Author(s)
      Atsushi Izuka, Naoki Miyamoto, Ayano Makinaga, Ryusuke Suzuki
    • Organizer
      第115回医学物理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Surface imaging and internal imaging what are they worth2018

    • Author(s)
      Naoki Miyamoto
    • Organizer
      4D Treatment Workshop for Particle Therapy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation of dosimetric error with utilizing respiratory motion modeling aimed for beam angle optimization in proton beam therapy2017

    • Author(s)
      Haruo Nakagawa, Naoki Miyamoto, Shusuke Hirayama, Hideaki Ueda, Kohei Yokokawa, Kikuo Umegaki
    • Organizer
      第114回医学物理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Yohei Arai, Hideaki Ueda, Haruo Nakagawa, Naoki Miyamoto, Kikuo Umegaki, Target tumor localization algorithm using multiple fiducial markers for Real-time Tumor-tracking Radiation Therapy2017

    • Author(s)
      Yohei Arai, Naoki Miyamoto, Hideaki Ueda, Kohei Yokokawa, Kikuo Umegaki
    • Organizer
      第114回医学物理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evaluation of measurement accuracy of novel monoscopic X-ray imaging technique for three-dimensional target localization using multiple internal fiducial markers2017

    • Author(s)
      Naoki Miyamoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Shusuke Hirayama, Takaaki Fujii, Satoshi Tomioka, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    • Organizer
      第114回医学物理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Monoscopic X-ray imaging for real-time three-dimensional target localization using multiple internal fiducial markers2017

    • Author(s)
      Naoki Miyamoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Takaaki Fujii, Yusuke Hirayama, Hidenori Koyano, Shinichi Shimizu, Kikuo Umegaki and Hiroki Shirato
    • Organizer
      2017 AAPM Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2025-11-20  

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