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Associations of antibiotic resistance with antibiotic use and the promotion of infection control measures: Analyses using medical big data

Research Project

Project/Area Number 17H04144
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical and hospital managemen
Research InstitutionKyushu University

Principal Investigator

Fukuda Haruhisa  九州大学, 医学研究院, 准教授 (30572119)

Co-Investigator(Kenkyū-buntansha) 下野 信行  九州大学, 大学病院, 准教授 (70346782)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords抗菌薬 / 耐性菌 / 薬剤感受性 / DPC / JANIS / NDB / 感染症 / 費用効果分析 / レセプトデータ / 感受性
Outline of Final Research Achievements

The following four research topics were addressed: (1) Elucidation of the association between antibiotic resistance onset and antibiotic use, (2) Visualization of antibiotic treatment strategies and evaluation of appropriate use, (3) Effectiveness evaluation of appropriate antibiotic use support programs, and (4) Healthcare economic evaluation of antibiotic resistance onset and antibiotic use. For each topic, medical big data (including DPC data, JANIS data, payment data, and NDB data) were utilized as appropriate to quantitatively analyze the associations between the real-world conditions of antibiotic resistance and antibiotic use.

Academic Significance and Societal Importance of the Research Achievements

薬剤耐性菌は世界的に蔓延し,決定的に重大な国際課題である.本研究では我が国に整備されている医療ビッグデータを活用し,耐性菌および抗菌薬の実態を可視化する方法を開発した.また,継続的に可視化がなされることにより,薬剤耐性菌発現の抑止に貢献しうることが明らかにされた.さらに,感染症発症による追加敵医療費を推定することにより,経済性の観点から感染対策の開発推進に資する成果をあげた.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (14 results)

All 2020 2019 2018 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Antimicrobial utilization and antimicrobial resistance in patients with haematological malignancies in Japan: a multi-centre cross-sectional study2020

    • Author(s)
      Mimura Wataru、Fukuda Haruhisa、Akazawa Manabu
    • Journal Title

      Annals of Clinical Microbiology and Antimicrobials

      Volume: 19 Issue: 1 Pages: 1-8

    • DOI

      10.1186/s12941-020-00348-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Healthcare Expenditures for the Treatment of Patients Infected with Hepatitis C Virus in Japan2020

    • Author(s)
      Haruhisa Fukuda, Yoshihiko Yano, Daisuke Sato, Sachiko Ohde, Shinichi Noto, Ryo Watanabe & Osamu Takahashi
    • Journal Title

      PharmacoEconomics

      Volume: 38 Issue: 3 Pages: 297-306

    • DOI

      10.1007/s40273-019-00861-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inpatient Expenditures Attributable to Hospital-Onset Clostridium difficile Infection: A Nationwide Case?Control Study in Japan2018

    • Author(s)
      Fukuda Haruhisa、Yano Takahisa、Shimono Nobuyuki
    • Journal Title

      PharmacoEconomics

      Volume: 36 Issue: 11 Pages: 1367-1376

    • DOI

      10.1007/s40273-018-0692-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 夜間・休日の時間外受診における 抗菌薬処方および翌日の未受診状況.2019

    • Author(s)
      前田恵, 福田治久, 日馬由貴, 松永展明, 大曲貴夫.
    • Organizer
      第57回日本医療・病院管理学会学術総会.
    • Related Report
      2019 Annual Research Report
  • [Presentation] Assessment of record linkage using administrative claims data and antimicrobial susceptibility testing data.2019

    • Author(s)
      Mimura W, Fukuda H, Konomura K, Akazawa M.
    • Organizer
      ISPE's 12th Asian Conference on Pharmacoepidemiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antimicrobial utilization and infection caused by Gram-negative bacteria in patients with haematological malignancies in Japan: A multi-centre cross-sectional study.2019

    • Author(s)
      Mimura W, Fukuda H, Akazawa M.
    • Organizer
      ISPOR Europe 2019.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗菌薬使用が薬剤感受性に及ぼす効果:Antimicrobial Consumption Improvement Project.2019

    • Author(s)
      福田治久,矢野貴久,下野信行.
    • Organizer
      第34回日本環境感染学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] JANIS検査部門の還元情報が薬剤感受性に及ぼす効果.2019

    • Author(s)
      福田治久,藤田烈.
    • Organizer
      第34回日本環境感染学会総会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] 成人市中肺炎における抗菌薬使用状況の検証:Antimicrobial Consumption Improvement Project.2019

    • Author(s)
      一番ヶ瀬智和,福田治久.
    • Organizer
      第34回日本環境感染学会総会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] 整形外科領域のSSIと医療経済2019

    • Author(s)
      福田治久.
    • Organizer
      第42回日本骨・関節感染症学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Attributable inpatient costs of hospital-onset Clostridium difficile infection: a nationwide case-control study in Japan.2018

    • Author(s)
      Fukuda H, Yano T, Shimono N.
    • Organizer
      IDWeek2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カルバペネム系抗菌薬の使用量と緑膿菌のカルバペネム系抗菌薬への感受性の関係:多施設比較研究.2018

    • Author(s)
      金子拓也, 福田治久, 三村美智, 此村恵子, 赤沢学.
    • Organizer
      第138回日本薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 急性期病院における抗緑膿菌薬の処方実態と薬剤耐性菌発生率の関係.2018

    • Author(s)
      三村美智, 福田治久, 金子拓也, 此村恵子, 赤沢学.
    • Organizer
      第138回日本薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 九州大学大学院医学研究院医療経営学分野ウェブサイト

    • URL

      https://sites.google.com/site/hcamfukuda/home

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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