Combined study of drug therapy for appetite loss and fatigue due to cancer cachexia

• Project/Area Number: 17H04149
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: Inoue Akira 東北大学, 医学系研究科, 教授 (70361087)
• Co-Investigator(Kenkyū-buntansha): 森田 達也 聖隷クリストファー大学, 看護学研究科, 臨床教授 (70513000) ; 宮下 光令 東北大学, 医学系研究科, 教授 (90301142)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
• Keywords: 緩和医療 / がん

Outline of Final Research Achievements

"Prospective intervention study comparing different dosages of steroid therapy" was conducted in a multicenter collaborative study group (UMIN000022448). Although progress was delayed due to the spread of COVID-19 infection, the trial is scheduled to be completed by the end of this year, and evidence of steroid treatment for anorexia will be established for the first time in Japan.
On the other hand, large-scale nationwide registry studies have identified factors that can predict "time to incapacity" and "time to immobility" in end-of-life cancer patients, and research studies include loss of appetite. It was shown that high QOL can be obtained by setting individual goals for each patient and coping with them.

Academic Significance and Societal Importance of the Research Achievements

進行がんの悪液質により生じる食欲不振・倦怠感への薬物療法については現在に至るまでも信頼に足るエビデンスが乏しい状況が続いており、前向き研究による質の高いエビデンスが求められている。本研究では、質の高い多施設共同研究によって食欲不振に用いるためのステロイドの適切な用法用量のエビデンスが得られ、上記症状を呈するがん患者への薬物療法の質を向上させた点で重要である。さらに大規模観察研究や調査研究で得られた「患者に残された機能の予後予測指標」や「QOLを高める個別化した症状緩和」も、医療現場において適切な緩和ケアを提供するために重要な知見であり、社会的意義は大きい。

Research Products

• [Journal Article] Prognostic model for patients with advanced cancer using a combination of routine blood test values (2021)
  • Author(s): Miyagi Taeko、Miyata Satoshi、Tagami Keita、Hiratsuka Yusuke、Sato Mamiko、Takeda Ikuo、Kohata Katsura、Satake Noriaki、Shimokawa Hiroaki、Inoue Akira
  • Journal Title: Supportive Care in Cancer Volume: - Issue: 8 Pages: 4431-4437
  • DOI: 10.1007/s00520-020-05937-5
  • Peer Reviewed
• [Journal Article] Patients' understanding of communication about palliative care and health condition in Japanese patients with unresectable or recurrent cancer: a cross-sectional survey (2021)
  • Author(s): Yusuke Hiratsuka, Takayuki Oishi, Mitsunori Miyashita, Tatsuya Morita, Jennifer W Mack, Masahiro Takahashi, Hidekazu Shirota, Kazunori Otsuka, Chikashi Ishioka, Akira Inoue
  • Journal Title: Ann Palliat Med Volume: 10 Issue: 3 Pages: 2650-2661
  • DOI: 10.21037/apm-20-2045
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of molecular targeting agents and immune-checkpoint inhibitors in patients with advanced cancer who are near the end of life (2021)
  • Author(s): Hiramoto Shuji、Taniyama Tomohiko、Kikuchi Ayako、Hori Tetsuo、Yoshioka Akira、Inoue Akira
  • Journal Title: Palliative and Supportive Care Volume: - Issue: 6 Pages: 1-6
  • DOI: 10.1017/s147895152100002x
  • Peer Reviewed
• [Journal Article] The association between health-related quality of life and achievement of personalized symptom goal (2020)
  • Author(s): Tagami Keita、Kawaguchi Takashi、Miura Tomofumi、Yamaguchi Takuhiro、Matsumoto Yoshihisa、Watanabe Yuki Sumazaki、Uehara Yuko、Okizaki Ayumi、Inoue Akira、Morita Tatsuya、Kinoshita Hiroya
  • Journal Title: Supportive Care in Cancer Volume: 28 Issue: 10 Pages: 4737-4743
  • DOI: 10.1007/s00520-020-05316-0
  • Peer Reviewed
• [Journal Article] The Functional Palliative Prognostic Index: a scoring system for functional prognostication of patients with advanced cancer. (2020)
  • Author(s): Hiratsuka Y, Yamaguchi T, Maeda I, Morita T, Mori M, Yokomichi N, Hiramoto S, Matsuda Y, Kohara H, Suzuki K, Tagami K, Yamaguchi T, Inoue A.
  • Journal Title: Support Care Cancer Volume: Epub ahead of print Issue: 12 Pages: 6067-6074
  • DOI: 10.1007/s00520-020-05408-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Survival and prognostic factors in elderly patients receiving second-line chemotherapy for relapsed small-cell lung cancer: Results from the Japanese Joint Committee of Lung Cancer Registry (2020)
  • Author(s): Igawa, S. Naoki, K. Shintani, Y. Sekine, I. Shukuya, T. Takayama, K. Inoue, A. Okamoto, I. Kiura, K. Takahashi, K. Yamamoto, N. Takiguchi, Y. Miyaoka, E. Okumura, M. Yoshino, I.
  • Journal Title: Lung Cancer Volume: 146 Pages: 160-164
  • DOI: 10.1016/j.lungcan.2020.05.038
  • Peer Reviewed
• [Journal Article] Key prognostic factors for EGFR-mutated non-adenocarcinoma lung cancer patients in the Japanese Joint Committee of Lung Cancer Registry Database (2020)
  • Author(s): Kobayashi, K. Soejima, K. Fukunaga, K. Shintani, Y. Sekine, I. Shukuya, T. Takayama, K. Inoue, A. Okamoto, I. Kiura, K. Takahashi, K. Yamamoto, N. Takiguchi, Y. Miyaoka, E. Okumura, M. Yoshino, I.
  • Journal Title: Lung Cancer Volume: 146 Pages: 236-243
  • DOI: 10.1016/j.lungcan.2020.06.015
  • Peer Reviewed
• [Journal Article] The current clinical use of adjuvant analgesics for refractory cancer pain in Japan: a nationwide cross-sectional survey (2020)
  • Author(s): Tagami Keita、Matsuoka Hiromichi、Ariyoshi Keisuke、Oyamada Shunsuke、Hiratsuka Yusuke、Kizawa Yoshiyuki、Koyama Atsuko、Inoue Akira
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 50 Issue: 12 Pages: 1434-1441
  • DOI: 10.1093/jjco/hyaa147
  • Peer Reviewed
• [Journal Article] Does Pemetrexed Work in Targetable, Nonsquamous Non-Small-Cell Lung Cancer? A Narrative Review (2020)
  • Author(s): Shih Jin-Yuan、Inoue Akira、Cheng Rebecca、Varea Rocio、Kim Sang-We
  • Journal Title: Cancers Volume: 12 Issue: 9 Pages: 2658-2658
  • DOI: 10.3390/cancers12092658
  • Peer Reviewed
• [Journal Article] Multiplex gene‐panel testing for lung cancer patients (2020)
  • Author(s): Yatabe Yasushi、Sunami Kuniko、Goto Koichi、Nishio Kazuto、Aragane Naoko、Ikeda Sadakatsu、Inoue Akira、Kinoshita Ichiro、Kimura Hideharu、Sakamoto Tomohiro、Satouchi Miyako、Shimizu Junichi、Tsuta Koji、Toyooka Shinichi、Nishino Kazumi、Hatanaka Yutaka、Matsumoto Shingo、Mikubo Masashi、et al.
  • Journal Title: Pathology International Volume: 70 Issue: 12 Pages: 921-931
  • DOI: 10.1111/pin.13023
  • Peer Reviewed
• [Journal Article] Factors influencing spiritual well-being in terminally ill cancer inpatients in Japan (2020)
  • Author(s): Hiratsuka Yusuke、Suh Sang-Yeon、Maeda Isseki、Morita Tatsuya、Mori Masanori、Ito Satoko、Nishi Tomohiro、Hisanaga Takayuki、Iriyama Tetsuji、Kaneishi Keisuke、Ikari Tomoo、Tagami Keita、Inoue Akira
  • Journal Title: Supportive Care in Cancer Volume: 29 Issue: 5 Pages: 2795-2802
  • DOI: 10.1007/s00520-020-05802-5
  • Peer Reviewed
• [Journal Article] Randomized phase II trial of carboplatin + nab-paclitaxel versus cisplatin + gemcitabine for chemotherapy-naive squamous cell carcinoma: North Japan lung cancer study group 1302 (2020)
  • Author(s): Kawashima Yosuke、Harada Toshiyuki、Fujita Yuka、Nakagawa Taku、Watanabe Kana、Morikawa Naoto、Takamura Kei、Kanazawa Kenya、Kuda Tomoya、Usui Kazuhiro、Sekine Akimasa、Inoue Akira、Sugawara Shunichi
  • Journal Title: International Journal of Clinical Oncology Volume: 26 Issue: 3 Pages: 515-522
  • DOI: 10.1007/s10147-020-01828-1
  • Peer Reviewed
• [Journal Article] Effectiveness of gabapentinoids for cancer-related rectal and vesical tenesmus: Report of four cases (2020)
  • Author(s): Tagami Keita、Yoshizumi Masaru、Inoue Akira、Matoba Motohiro
  • Journal Title: Indian Journal of Palliative Care Volume: 26 Issue: 3 Pages: 381-381
  • DOI: 10.4103/ijpc.ijpc_203_19
  • Peer Reviewed
• [Journal Article] Randomized phase II trial of uracil/tegafur and cisplatin versus pemetrexed and cisplatin with concurrent thoracis radiotherapy for locally advanced unresectable stage III non-squamous non-small cell lung cancer: NJLCG1001 (2020)
  • Author(s): K.Watanabe, Y.Toi, A.Nakamura, R.Chiba, M.Akiyama, J.Sakakibara-Konishi, H.Tanaka, N.Yoshimura, E.Miyauchi, T.Nakagawa, R.Igusa, H.Minemura, Y.Mori, K.Fujimoto, H.Matsushita, F.Takahashi, T.Fukuhara, A.Inoue, S.Sugawara, M.Maemonndo
  • Journal Title: Transl Lung Cancer Res. Volume: 10 Issue: 2 Pages: 712-722
  • DOI: 10.21037/tlcr-20-721
  • Peer Reviewed
• [Journal Article] “3‐Day Surprise Question” to predict prognosis of advanced cancer patients with impending death: Multicenter prospective observational study (2020)
  • Author(s): Ikari Tomoo、Hiratsuka Yusuke、Yamaguchi Takuhiro、Maeda Isseki、Mori Masanori、Uneno Yu、Taniyama Tomohiko、Matsuda Yosuke、Oya Kiyofumi、Tagami Keita、Inoue Akira
  • Journal Title: Cancer Medicine Volume: 10 Issue: 3 Pages: 1018-1026
  • DOI: 10.1002/cam4.3689
  • Peer Reviewed
• [Journal Article] Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study (2020)
  • Author(s): Hosomi Yukio、Morita Satoshi、Sugawara Shunichi、Kato Terufumi、Fukuhara Tatsuro、Gemma Akihiko、Takahashi Kazuhisa、Fujita Yuka、Harada Toshiyuki、Minato Koichi、Takamura Kei、Hagiwara Koichi、Kobayashi Kunihiko、Nukiwa Toshihiro、Inoue Akira、for the North-East Japan Study Group
  • Journal Title: Journal of Clinical Oncology Volume: 38 Issue: 2 Pages: 115-123
  • DOI: 10.1200/jco.19.01488
  • Peer Reviewed
• [Journal Article] Phase II study of S-1 in patients with previously-treated invasive thymoma and thymic carcinoma: North Japan lung cancer study group trial 1203 (2020)
  • Author(s): Tsukita Yoko、Inoue Akira、Sugawara Shunichi、Kuyama Shoichi、Nakagawa Taku、Harada Daijiro、Tanaka Hisashi、Watanabe Kana、Mori Yoshiaki、Harada Toshiyuki、Hino Toshihiko、Fujii Masanori、Ichinose Masakazu
  • Journal Title: Lung Cancer Volume: 139 Pages: 89-93
  • DOI: 10.1016/j.lungcan.2019.10.016
  • Peer Reviewed
• [Journal Article] A Japanese lung cancer registry study on demographics and treatment modalities in medically treated patients (2020)
  • Author(s): Sekine Ikuo、Shintani Yasushi、Shukuya Takehito、Takayama Koichi、Inoue Akira、Okamoto Isamu、Kiura Katsuyuki、Takahashi Kazuhisa、Dosaka‐Akita Hirotoshi、Takiguchi Yuichi、Miyaoka Etsuo、Okumura Meinoshin、Yoshino Ichiro
  • Journal Title: Cancer Science Volume: - Issue: 5 Pages: 1685-1691
  • DOI: 10.1111/cas.14368
  • NAID: 120007159552
  • Peer Reviewed
• [Journal Article] Explicit prognostic disclosure to Asian women with breast cancer: A randomized, scripted video-vignette study (J-SUPPORT1601). (2019)
  • Author(s): Mori M, Fujimori M, van Vliet LM, Yamaguchi T, Shimizu C, Kinoshita T, Morishita-Kawahara M, Inoue A, Inoguchi H, Matsuoka Y, Bruera E, Morita T, Uchitomi Y.
  • Journal Title: Cancer Volume: 125 Issue: 19 Pages: 3320-3329
  • DOI: 10.1002/cncr.32327
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Attitude of Japanese palliative care specialists towards adjuvant analgesics cancer-related neuropathic pain refractory to opioid therapy: a nationwide cross-sectional survey. (2019)
  • Author(s): Matsuoka H, Tagami K, Ariyoshi K, Oyamada S, Kizawa Y, Inoue A, Koyama A.
  • Journal Title: Jpn J Clin Oncol Volume: 49 Issue: 5 Pages: 486-490
  • DOI: 10.1093/jjco/hyz002
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic factors in patients who received end-of-life chemotherapy for advanced cancer. (2019)
  • Author(s): 102)Hiramoto S, Tamaki T, Nagashima K, Hori T, Kikuchi A, Yoshioka A, Inoue A.
  • Journal Title: International Journal of Clinical Oncology Volume: 24 Pages: 454-459
  • Peer Reviewed
• [Journal Article] Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas (2019)
  • Author(s): Tsukita Yoko、Fujino Naoya、Miyauchi Eisaku、Saito Ryoko、Fujishima Fumiyoshi、Itakura Koji、Kyogoku Yorihiko、Okutomo Koji、Yamada Mitsuhiro、Okazaki Tatsuma、Sugiura Hisatoshi、Inoue Akira、Okada Yoshinori、Ichinose Masakazu
  • Journal Title: Molecular Cancer Volume: 18 Issue: 1 Pages: 24-24
  • DOI: 10.1186/s12943-019-0953-y
  • Peer Reviewed / Open Access