| Budget Amount *help |
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
During cancer development, cancer stem cells are closely associated with hierarchy and plasticity of cancer tissues. Previously, we reported that Dclk1 is one of the cancer stem cell-specific markers, and that SWI/SNF complex regulates differentiation of gastrointestinal cancers. Based on these findings, we here investigated (1) therapeutic strategy by utilizing cancer hierarchy and cancer stem cells, (2) therapeutic strategy by focusing on plasticity and differentiation status, and (3) detrermined them in organoid and patient-derived xenograft systems. These experiments indicated fundamental data to develop novel therapeutic strategies against various gastrointestinal cancers.
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