Role of regeneration nodule in cirrhotic liver on tumorigenesis
| Project/Area Number |
17H04158
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 肝癌 / 肝硬変 / 遺伝子異常 / 癌 / ゲノム / ウィルス |
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| Outline of Final Research Achievements |
Hepatocellular carcinoma recurrently develops in cirrhotic liver containing a number of regenerative nodules (RNs). To uncover the molecular basis of tumorigenesis in liver cirrhosis, the genetic aberrations in RNs of cirrhotic tissues were determined using next-generation sequencing method. Our findings suggested that a variety of genetic aberrations accmulate in the RNs of cirrhotic liver before the development of clinically and histologically overt HCC, and these aberrations in RNs could provide the basis of tumorigenesis in patients with liver cirrhosis.
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| Academic Significance and Societal Importance of the Research Achievements |
本邦でも頻度の高い癌のひとつである肝癌は肝硬変を背景に高率に発生することが知られている。この肝硬変は、肝臓の線維化と再生結節と呼ばれる肝細胞の構成単位により形成されているが、本研究により肝硬変の再生結節に遺伝子異常が蓄積することが、肝癌の発生母地となっていることがわかってきた。
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Report
(4 results)
Research Products
(5 results)
