Investigation of the pathogenesis of intractable inflammatory bowel diseases: the role of innate lymphoid cells in the mucosal immune system

• Project/Area Number: 17H04159
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: Iijima Hideki 大阪大学, 医学系研究科, 准教授 (90444520)
• Co-Investigator(Kenkyū-buntansha): 井上 隆弘 大阪大学, 共創機構, 准教授 (30648184) ; 新崎 信一郎 大阪大学, 医学系研究科, 講師 (60546860) ; 林 義人 大阪大学, 医学系研究科, 助教 (80647123) ; 辻井 芳樹 大阪大学, 医学系研究科, 寄附講座助教 (80795170) ; 川井 翔一朗 大阪大学, 医学部附属病院, 医員 (10771321)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 腸管粘膜遊走 / 非ステロイド性消炎鎮痛薬 / 小腸粘膜バリア / 小腸粘膜傷害 / 腸内細菌 / CCR7 / NSAIDs / 腸管免疫 / 樹状細胞 / 小腸粘膜障害 / 粘膜免疫 / ケモカインレセプター / 非ステロイド系消炎鎮痛薬 / 脂質代謝物 / IL-22BP / NSAIDｓ / 炎症性腸疾患 / 自然リンパ球 / IL-22 / AhR

Outline of Final Research Achievements

A chemokine receptor, CCR7 is involved in immune-related cell motility of the mucosal immune system. Mucosal injury of the small intestine caused by intraperitoneal administration of a non-steroidal anti-inflammatory drug (NSAID), indomethacin, was significantly worse in chemokine receptor CCR7-deficient mice than in wild-type mice. The mucosal injury was related to the expression of interleukin (IL)-22 binding protein (IL-22BP) produced by dendritic cells which inhibits the mucosal barrier function by IL-22. This study revealed that cell migration in the gastrointestinal mucosal immune system plays an important role in preventing gastrointestinal mucosal injury caused by NSAID.

Academic Significance and Societal Importance of the Research Achievements

非ステロイド性消炎鎮痛剤(NSAID)の使用に伴う腸管粘膜傷害における粘膜免疫系の役割についての詳細は不明であったが、本研究によりCCR7というホーミングレセプターの非存在下では腸管粘膜バリアの恒常性維持に関わるIL-22を阻害するCD103陽性樹状細胞が多く存在し、腸管炎症を増悪させることを世界で初めて示した。本研究は、NSAIDによる消化管粘膜傷害の予防法を確立する上で重要であり、新規治療法の開発の端緒となり、安全な疼痛コントロール法の確立に寄与することが期待される。

Research Products

• [Journal Article] Concomitant use of an immunomodulator with ustekinumab as an induction therapy for Crohn's disease: A systematic review and meta-analysis (2021)
  • Author(s): Takeo Yoshihara, Shinichiro Shinzaki, Takahiro Amano, Hideki Iijima, Tetsuo Takehara, Nagamu Inoue, Motoi Uchino, Motohiro Esaki, Taku Kobayashi, Masayuki Saruta, Ken Sugimoto, Shiro Nakamura, Keisuke Hata, Fumihito Hirai, Sakiko Hiraoka, Toshimitsu Fujii, Minoru Matsuura, Katsuyoshi Matsuoka, Kenji Watanabe, et al
  • Journal Title: J Gastroenterol Hepatol Volume: 15 Issue: 7 Pages: 1744-1753
  • DOI: 10.1111/jgh.15401
  • Peer Reviewed
• [Journal Article] Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation (2021)
  • Author(s): Kurashima Yosuke、Kigoshi Takaaki、Murasaki Sayuri、Arai Fujimi、Shimada Kaoru、Seki Natsumi、Kim Yun-Gi、Hase Koji、Ohno Hiroshi、Kawano Kazuya、Ashida Hiroshi、Suzuki Toshihiko、Morimoto Masako、Saito Yukari、Sasou Ai、Goda Yuki、Yuki Yoshikazu、Inagaki Yutaka、Iijima Hideki、Suda Wataru、Hattori Masahira
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 1067-1067
  • DOI: 10.1038/s41467-021-21277-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel mass spectrometry-based comprehensive lipidomic analysis of plasma from patients with inflammatory bowel disease. (2020)
  • Author(s): Iwatani S, Iijima H, Otake Y, Amano T, Tani M, Yoshihara T, Tashiro T, Tsujii Y, Inoue T, Hayashi Y, Takeda K, Hayashi A, Fujita S, Shinzaki S, Takehara T.
  • Journal Title: J Gastroenterol Hepatol. Volume: - Issue: 8 Pages: 1355-1364
  • DOI: 10.1111/jgh.15067
  • Peer Reviewed
• [Journal Article] Oligosaccharide‐dependent anti‐inflammatory role of galectin‐1 for macrophages in ulcerative colitis (2020)
  • Author(s): Iwatani Shuko、Shinzaki Shinichiro、Amano Takahiro、Otake Yuriko、Tani Mizuki、Yoshihara Takeo、Tsujii Yoshiki、Hayashi Yoshito、Inoue Takahiro、Okuzaki Daisuke、Mizushima Tsunekazu、Miyoshi Eiji、Iijima Hideki、Takehara Tetsuo
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 35 Issue: 12 Pages: 2158-2169
  • DOI: 10.1111/jgh.15097
  • Peer Reviewed
• [Journal Article] Psychologic stress and disease activity in patients with inflammatory bowel disease: A multicenter cross-sectional study (2020)
  • Author(s): Araki M, Shinzaki S, Yamada T, Arimitsu S, Komori M, Shibukawa N, Mukai A, Nakajima S, Kinoshita K, Kitamura S, Murayama Y, Ogawa H, Yasunaga Y, Oshita M, Fukui H, Masuda E, Tsujii M, Kawai S, Hiyama S, Inoue T, Tanimukai H, Iijima H, Takehara T.
  • Journal Title: PLOS ONE Volume: 15 Issue: 5 Pages: e0233365-e0233365
  • DOI: 10.1371/journal.pone.0233365
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic Alterations in Peyer's Patches in Patients With Ulcerative Colitis: A Prospective, Multicenter Study. (2020)
  • Author(s): Hiyama S, Iijima H, Sakakibara Y, Yamada T, Mukai A, Otake Y, Yamaguchi T, Araki M, Kawai S, Tsujii Y, Inoue T, Hayashi Y, Shinzaki S, Takehara T.
  • Journal Title: J Gastroenterol Hepatol. Volume: - Issue: 7 Pages: 1143-1149
  • DOI: 10.1111/jgh.14933
  • Peer Reviewed
• [Journal Article] A Novel Predictive Nomogram for Early Endoscopic Recurrence after Intestinal Resection for Crohn's Disease (2019)
  • Author(s): A. Ikeda, N. Miyoshi, S. Fujino, H. Iijima, H. Takahashi, N. Haraguchi, J. Nishimura, T. Hata, C. Matsuda, Y. Doki, M. Mori, T. Mizushima
  • Journal Title: Digestion Volume: 100(4) Issue: 4 Pages: 269-276
  • DOI: 10.1159/000495981
  • Peer Reviewed
• [Journal Article] Usefulness of intestinal real-time virtual sonography in patients with inflammatory bowel disease. (2019)
  • Author(s): Kawai S, Iijima H, Shinzaki S, Hiyama S, Yamaguchi T, Araki M, Iwatani S, Shiraishi E, Mukai A, Inoue T, Tsujii Y, Hayashi Y, Tsujii M, Takehara T.
  • Journal Title: J Gastroenterol Hepatol. Volume: 34(10) Issue: 10 Pages: 1743-1743
  • DOI: 10.1111/jgh.14670
  • Peer Reviewed
• [Journal Article] Postoperative therapy with infliximab for Crohn’s disease: a 2-year prospective randomized multicenter study in Japan (2018)
  • Author(s): Fukushima Kouhei、Surgical Research Group, Sugita Akira、Futami Kitaro、Takahashi Ken-Ichi、Motoya Satoshi、Kimura Hideaki、Yoshikawa Shusaku、Kinouchi Yoshitaka、Iijima Hideki、Endo Katsuya、Hibi Toshihumi、Watanabe Mamoru、Sasaki Iwao、Suzuki Yasuo
  • Journal Title: Surgery Today Volume: 48 Issue: 6 Pages: 584-590
  • DOI: 10.1007/s00595-018-1627-x
  • Peer Reviewed
• [Journal Article] Adenoma of colorectal laterally spreading tumor nongranular type with biological phenotypic features similar to cancer (2018)
  • Author(s): Nagai Kengo、Hayashi Yoshito、Honma Keiichiro、Sakatani Akihiko、Yoshii Shunsuke、Fujinaga Tetsuji、Maekawa Akira、Tsujii Yoshiki、Hiyama Satoshi、Shinzaki Shinichiro、Watabe Kenji、Iijima Hideki、Tsujii Masahiko、Mizushima Tsunekazu、Morii Eiichi、Takehara Tetsuo
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 33 Issue: 11 Pages: 1853-1863
  • DOI: 10.1111/jgh.14284
  • Peer Reviewed
• [Journal Article] Intestinal Epithelial Cell-specific Deletion of α-Mannosidase II Ameliorates Experimental Colitis (2018)
  • Author(s): Suzuki K., Yamada T, Yamazaki K, Hirota M, Ishihara N, Sakamoto M, Takahashi D, Iijima H, Hase K.
  • Journal Title: Cell Structure and Function Volume: 43 Issue: 1 Pages: 25-39
  • DOI: 10.1247/csf.17022
  • NAID: 130006513071
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed / Open Access
• [Journal Article] 炎症性腸疾患の病態研究の現状と今後の展望 (2018)
  • Author(s): 飯島 英樹、新﨑 信一郎、竹原 徹郎
  • Journal Title: 日本消化器病学会誌 Volume: 115(3) Pages: 244-253
  • NAID: 130006483391
  • Peer Reviewed
• [Journal Article] 炎症性腸疾患の免疫学的メカニズムと薬剤開発 (2018)
  • Author(s): 飯島 英樹
  • Journal Title: 実験医学 Volume: 18(11) Pages: 3081-3085
• [Journal Article] Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease (2017)
  • Author(s): Araki, M, Shinzaki, S., Yamada, T., Arimitsu S., Komori, M., Shibukawa, N., Mukai A., Nakajima, S., Kinoshita, K., Kitamura, S., Murayama, Y., Ogawa H., Yasunaga Y, Oshita, M., Fukui, H., Masuda E., Tsujii, M., Hiyama, S., Inoue, T., Iijima, H., Takehara, T.
  • Journal Title: Journal of Gastroenterology Volume: 印刷中 Issue: 11 Pages: 1149-1157
  • DOI: 10.1007/s00535-017-1313-6
  • Peer Reviewed
• [Journal Article] Clinical use of molecular targeted agents for primary small bowel adenocarcinoma: A multicenter retrospective cohort study by the Osaka Gut Forum (2017)
  • Author(s): Hirao Motohiro、Komori Masato、Nishida Tsutomu、Iijima Hideki、Yamaguchi Shinjiro、Ishihara Ryu、Yasunaga Yuichi、Kobayashi Ichizo、Kishida Osamu、Oshita Masahide、Hagiwara Hideki、Ito Toshifumi、Suzuki Kunio、Hayashi Yoshito、Inoue Takahiro、Tsujii Masahiko、Yoshihara Harumasa、Takehara Tetsuo
  • Journal Title: Oncology Letters Volume: 14 Issue: 2 Pages: 1628-1636
  • DOI: 10.3892/ol.2017.6290
  • Peer Reviewed
• [Journal Article] Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation. (2017)
  • Author(s): Kawai S, Iijima H, Shinzaki S, Hiyama S, Yamaguchi T, Araki M, et al.
  • Journal Title: J Gastroenterol. Volume: 印刷中 Issue: 8 Pages: 904-919
  • DOI: 10.1007/s00535-016-1292-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Adherence to an elemental diet for preventing postoperative recurrence of Crohn’s disease (2017)
  • Author(s): Ohara Nobuyoshi、Mizushima Tsunekazu、Iijima Hideki、Takahashi Hidekazu、Hiyama Satoshi、Haraguchi Naotsugu、Inoue Takahiro、Nishimura Junichi、Shinzaki Shinichiro、Hata Taishi、Matsuda Chu、Yamamoto Hirofumi、Doki Yuichiro、Mori Masaki
  • Journal Title: Surgery today Volume: 47 Issue: 12 Pages: 1519-1525
  • DOI: 10.1007/s00595-017-1543-5
  • Peer Reviewed
• [Journal Article] Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis (2017)
  • Author(s): Shinzaki, S., Matsuoka, K., Iijima, H., Mizuno, S., Serada, S., Fujimoto, M., Arai, N. Koyama, N., Morii, E., Watanabe, M., Hibi, T., Kanai, T., Takehara, T., Naka, T.
  • Journal Title: Journal of Crohn's and Colitis Volume: 11(1) Issue: 1 Pages: 84-91
  • DOI: 10.1093/ecco-jcc/jjw132
  • Peer Reviewed
• [Presentation] 脂質代謝物lysophosopatidyulserineのマウス腸炎モデルにおける影響 (2020)
  • Author(s): 大竹由利子、新崎信一郎、飯島英樹 、田代拓，天野孝広，谷瑞季，良原丈夫，岩谷修子，辻井芳樹， 林義人，井上隆弘，竹原徹郎
  • Organizer: 第106回日本消化器病学会総会
• [Presentation] Recent advance of biomarkers for monitoring disease activity of IBD (2020)
  • Author(s): Iijima, Hideki
  • Organizer: JDDW
• [Presentation] Fecal Microbiota Related to the Seasonal Aggravation of IBD (2020)
  • Author(s): Tani M, Shinzaki S, Tashiro T, Amano T, Ootake Y, Yoshihara Y, Iwatani S, Tsujii Y, Hayashi Y, Inoue T, Iijima H, Takehara T
  • Organizer: Digestive Disease Week
  • Int'l Joint Research
• [Presentation] Strategy of selecting anti-TNF agent in patients with Crohn's Disease: A multi-center retrospective cohort study by the Osaka Gut Forum (2020)
  • Author(s): Amano T. ,Shinzaki S., Tashiro T. , Otake Y. , Tani M. , Yoshihara T., Iwatani S, Inoue T., Tsujii Y., Hayashi Y., Iijima H., Takehara T.
  • Organizer: ECCO
  • Int'l Joint Research
• [Presentation] FECAL MICROBIOTA RELATED TO THE SEASONAL AGGRAVATION OF IBD (2020)
  • Author(s): M. Tani, S. Shinzaki, T. Tashiro, T. Amano, Y. Ootake, T. Yoshihara, S. Iwatani, Y. Tsujii, Y. Hayashi, T. Inoue, H. Iijima and T. Takehara
  • Organizer: Digestive Disease Week
  • Int'l Joint Research
• [Presentation] MODIFIED GLASGOW PROGNOSTIC SCORE IS USEFUL FOR PREDICTING LONG-TERM CONTINUATION OF ANTI-TNF THERAPY IN PATIENTS WITH CROHN'S DISEASE (2019)
  • Author(s): T. Amano, S. Shinzaki, Y. Otake, M. Tani, T. Yoshihara, S. Iwatani, Y. Tsujii, T. Inoue, Y. Hayashi, H. Iijima and T. Takehara
  • Organizer: Digestive Disease Week
  • Int'l Joint Research
• [Presentation] USEFULNESS OF LEUCINE-RICH ALPHA-2-GLYCOPROTEIN (LRG) TO MONITOR THE EFFICACY OF ADALIMUMAB TREATMENT IN PATIENTS WITH ULCERATIVE COLITIS (PLANET STUDY) (2019)
  • Author(s): H. Iijima, S. Mizuno, S. Shinzaki, K. Matsuoka, H. Tanaka, F. Takeshima, S. Kato, T. Torisu, M. Nakagawa, S. Nakamura, N. Yoshimura, T. Kobayashi, A. Shiotani, F. Hirai, S. Hiraoka, M. Matsuura, Y. Suzuki, M. Watanabe, T. Takehara, T. Matsumoto, T. Naka, T. Kanai
  • Organizer: UEGW
  • Int'l Joint Research
• [Presentation] TARGETED LIPIDOMIC ANALYSIS OF THE PLASMA OF INFLAMMATORY BOWEL DISEASE PATIENTS (2019)
  • Author(s): S. Iwatani, H. Iijima, T. Amano, Y. Otake, M. Tani, T. Yoshihara, Y. Tsujii, Y. Hayashi, T. Inoue, S. Shinzaki, A. Hayashi, S. Fujita and T. Takehara
  • Organizer: Digestive Disease Week
  • Int'l Joint Research
• [Presentation] LYSOPHOSPHATIDYLSERINE DETERIORATES MURINE TNBS-INDUCED COLITIS (2019)
  • Author(s): Y. Otake, S. Shinzaki, H. Iijima, T. Amano, M. Tani, T. Yoshihara, S. Iwatani, Y. Tsujii, Y. Hayashi, T. Inoue, H. Akio, F. Setsuko and T. Tetsuo
  • Organizer: Digestive Disease Week
  • Int'l Joint Research
• [Presentation] USEFULNESS OF SERUM LEUCINE-RICH ALPHA-2-GLYCOPROTEIN (LRG) FOR MONITORING THE EFFICACY OF ADALIMUMAB TREATMENT IN PATIENTS WITH CROHN'S DISEASE (PLANET STUDY) (2019)
  • Author(s): S. Shinzaki, K. Matsuoka, H. Iijima, S. Mizuno, H. Tanaka, F. Takeshima, S. Kato, T. Torisu, T. Nakagawa, S. Nakamura, N. Yoshimura, T. Kobayashi, A. Shiotani, F. Hirai, S. Hiraoka, M. Matsuura, Y. Suzuki, M. Watanabe, T. Takehara, T. Matsumoto, T. Naka and T. Kanai
  • Organizer: UEGW
  • Int'l Joint Research
• [Presentation] DEFICIENCY OF CCR7 IS RESPONSIBLE FOR THE DETERIORATION OF NON-STEROIDAL ANTI-INFLAMMATORY DRUG-INDUCED ENTEROPATHY IN MICE (2018)
  • Author(s): T. Yamaguchi, H. Iijima, M. Tani, Y. Otake, T. Yoshihara, S. Iwatani, S. Kawai, T. Inoue, S. Shinzaki ,T. Takehara
  • Organizer: Digestive Disease Week,Washington D.C.
  • Int'l Joint Research
• [Presentation] OLIGOSACCHARIDE-DEPENDENT ANTI-INFLAMMATORY ROLE OF GALECTIN-1 IN INFLAMMATORY BOWEL DISEASE (2018)
  • Author(s): S. Iwatani, S. Shinzaki, H. Iijima, Y. Otake, M. Tani, T. Yoshihara, T. Yamaguchi, S. Kawai, Y. Tsujii, Y. Hayashi, T. Inoue, T. Tetsuo
  • Organizer: Digestive Disease Week,Washington D.C.
  • Int'l Joint Research
• [Presentation] 炎症性腸疾患におけるGalectin-1の糖鎖を介した抗炎症作用の解明 (2018)
  • Author(s): 岩谷修子, 新崎信一郎, 飯島英樹, 大竹由利子, 谷瑞季 良原丈夫, 山口利朗, 川井翔一朗, 辻井芳樹, 林義人, 井上隆弘，竹原徹郎
  • Organizer: JDDW2018（日本消化器病学会）
• [Presentation] IBD患者のLipidomics解析 (2018)
  • Author(s): 岩谷 修子, 飯島 英樹, 天野 孝広, 大竹 由利子, 谷 瑞季, 良原 丈夫, 辻井 芳樹, 井上 隆弘, 林 義人, 新崎 信一郎, 林 昭夫, 藤田 節子, 竹原 徹郎
  • Organizer: 第55回日本消化器免疫学会総会
• [Presentation] 潰瘍性大腸炎に対する青黛の臨床的効果と腸炎改善メカニズム (2018)
  • Author(s): 飯島 英樹
  • Organizer: 第３回日本肺高血圧・肺循環学会学術集会
  • Invited
• [Presentation] クローン病における生物学的製剤の血中濃度、組織濃度と治療効果 (2018)
  • Author(s): 良原 丈夫, 新崎 信一郎, 飯島 英樹, 竹原 徹郎
  • Organizer: 日本消化器病学会第108回例会
• [Presentation] Concentrations of anti-TNF agents in non-inflamed intestinal tissue are associated with the long-term outcome of patients with Crohn’s Disease, (2017)
  • Author(s): Yoshihara T, Shinzaki S, Yamaguchi T, Araki M, Kawai S, Hiyama S, Inoue T, Hayashi Y, Watabe K, Iijima H, Takehara T.
  • Organizer: 12th Congress of ECCO - Inflammatory Bowel Diseases
  • Int'l Joint Research
• [Presentation] Deficiency of CCR7 deteriorates non-steroidal anti-inflammatory drug-induced enteropathy in mice (2017)
  • Author(s): Yamaguchi T, Iijima H, Hiyama S, Yoshihara T, Iwatani S, Araki M, Kawai S, Inoue T, Shinzaki S, Takehara T.
  • Organizer: Digestive Disease Week
  • Int'l Joint Research
• [Presentation] Indigo naturalis ameliorates murine dextran sodium sulfate induced-colitis through the activation of aryl hydrocarbon receptor independently of IL-10. (2017)
  • Author(s): Kawai S, Iijima H, Shinzaki S, Yoshihara T, Iwatani S, Yamaguchi T, Araki M, Hiyama S, Inoue T, Hayashi Y, Tsujii M, Takehara T.
  • Organizer: Digestive Disease Week
  • Int'l Joint Research
• [Presentation] Exosomes derived from colon cancer cells promote tumor progression via the activation of fibroblasts in tumor microenvironment. (2017)
  • Author(s): Hayashi Y, Yoshii S, Tsujii Y, Inoue T, Kimura K, Sakatani A, Nagai K, Fujinaga T, Hiyama S, Inoue T, Shinzaki S, Watabe K, Iijima H, Takehara T.
  • Organizer: Digestive Disease Week
  • Int'l Joint Research
• [Presentation] Depressive psychological status is associated with disease exacerbation in remissive Crohn's disease patients: a prospective observational study. (2017)
  • Author(s): Araki M, Iijima H, Yoshihara T, Iwatani S, Yamaguchi T, Kawai S, Hiyama S, Inoue T, Shinzaki S, Takehara T.
  • Organizer: Digestive Disease Week
  • Int'l Joint Research
• [Presentation] パイエル板NBI拡大観察による潰瘍性大腸炎の臨床的再燃予測 (2017)
  • Author(s): 日山 智史, 飯島 英樹, 竹原 徹郎
  • Organizer: 第93回 日本消化器内視鏡学会総会
• [Presentation] クローン病術後栄養療法のアドヒアランスと吻合部内視鏡再発に対する治療効果 (2017)
  • Author(s): 水島 恒和, 大原 信福, 日山 智史, 松田 宙, 畑 泰司, 西村 潤一, 原口 直紹, 高橋 秀和, 新崎 信一郎, 飯島 英樹, 中島 清一, 山本 浩文, 土岐 祐一郎, 森 正樹
  • Organizer: 第103回日本消化器病学会総会
• [Presentation] 炎症性腸疾患におけるGalectin-1を介した抗炎症作用の解明 (2017)
  • Author(s): 岩谷 修子, 新﨑 信一郎, 飯島 英樹, 大竹 由利子, 谷 瑞季, 良原 丈夫, 山口 利朗, 川井 翔一朗, 井上 隆弘, 林 義人, 竹原 徹郎
  • Organizer: 第54回日本消化器免疫学会総会
• [Book] 消化器病サイエンス (2021)
  • Author(s): 飯島英樹
  • Total Pages: 3
  • Publisher: 先端医学社
  • ISBN: 9784865504927