Exosome Therapy for Liver Cirrhosis Using a Novel Regeneration Factor

• Project/Area Number: 17H04166
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tokai University
• Principal Investigator: INAGAKI Yutaka 東海大学, 医学部, 教授 (80193548)
• Co-Investigator(Kenkyū-buntansha): 紙谷 聡英 東海大学, 医学部, 准教授 (30321904) ; 住吉 秀明 東海大学, 医学部, 講師 (60343357)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
• Keywords: 肝線維症 / 肝再生 / エクソソーム / 肝臓学 / 再生医学 / 生体分子 / 内科

Outline of Final Research Achievements

OGFRL1 has been identified by this principal investigator as a novel exosome-contained protein that accelerates regeneration of fibrotic liver. Through experiments using murine and human specimens, we reveled dynamic changes in production and secretion of OGFRL1 during liver injury/fibrosis and regeneration after partial hepatectomy, and validated its clinical usefulness as a marker of repair and regeneration of the injured liver. In addition, administration of genetically engineered OGFRL1-containing exosome into mice with liver fibrosis dramatically improved the survival after partial hepatectomy, indicating its therapeutic application to manage patients with advanced liver fibrosis/cirrhosis.

Academic Significance and Societal Importance of the Research Achievements

近年のＣ型肝炎診療の進歩にもかかわらず、ウイルス消失後も残存する肝線維化は肝癌の発生母地として今なお大きな問題である。進行した肝硬変に合併した肝癌では術後の再生不全への懸念のため切除困難な症例も経験され、線維肝の修復状態を適切に評価して更なる再生を図る新たな方策が切望されている。
本研究では、研究代表者が自ら同定した新規のエクソソーム内包タンパク質について、その産生分泌動態と修復・再生のバイオマーカーとしての有用性、さらに肝線維症マウスに対する再生促進効果を検討することで、肝硬変に対するエクソソーム医療という新たな分野の創生を目指した。

Research Products

• [Journal Article] Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation (2021)
  • Author(s): Kurashima Yosuke、Kigoshi Takaaki、Murasaki Sayuri、Arai Fujimi、Shimada Kaoru、Seki Natsumi、Kim Yun-Gi、Hase Koji、Ohno Hiroshi、Kawano Kazuya、Ashida Hiroshi、Suzuki Toshihiko、Morimoto Masako、Saito Yukari、Sasou Ai、Goda Yuki、Yuki Yoshikazu、Inagaki Yutaka、Iijima Hideki、Suda Wataru、Hattori Masahira
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 1067-1067
  • DOI: 10.1038/s41467-021-21277-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Liver fibrosis:underlying mechanisms and clinical implication (2020)
  • Author(s): 稲垣 豊
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi Volume: 117 Issue: 1 Pages: 9-19
  • DOI: 10.11405/nisshoshi.117.9
  • NAID: 130007784888
  • ISSN: 0446-6586, 1349-7693
  • Year and Date: 2020-01-10
  • Peer Reviewed
• [Journal Article] A novel composite biomaterial made of jellyfish and porcine collagens accelerates dermal wound healing by enhancing re-epithelization and granulation tissue formation in mice (2020)
  • Author(s): Sumiyoshi H, Nakao S, Endo H, Yanagawa T, Nakano Y, Okamura Y, Kawaguchi AT, Inagaki Y.
  • Journal Title: Advances in Wound Care Volume: 9 Issue: 6 Pages: 295-311
  • DOI: 10.1089/wound.2019.1014
  • Peer Reviewed
• [Journal Article] Liver-specific knockout of B cell lymphoma 6 suppresses progression of non-alcoholic steatohepatitis in mice (2020)
  • Author(s): Chikada Hiromi、Ida Kinuyo、Nishikawa Yuji、Inagaki Yutaka、Kamiya Akihide
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 9704-9704
  • DOI: 10.1038/s41598-020-66539-z
  • Peer Reviewed / Open Access
• [Journal Article] Visualization and isolation of zone-specific murine hepatocytes that maintain distinct cytochrome P450 oxidase expression in primary culture (2020)
  • Author(s): Kasahara Daigo、Sumiyoshi Hideaki、Endo Hitoshi、Yanagawa Takayo、Nakano Yasuhiro、Matsuki Yuki、Nakao Sachie、Kamiya Akihide、Kimura Hiroshi、Inagaki Yutaka
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 528 Issue: 3 Pages: 420-425
  • DOI: 10.1016/j.bbrc.2020.05.202
  • Peer Reviewed / Open Access
• [Journal Article] Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment (2020)
  • Author(s): Endo Hitoshi、Owada Satoshi、Inagaki Yutaka、Shida Yukari、Tatemichi Masayuki
  • Journal Title: Redox Biology Volume: 36 Pages: 101643-101643
  • DOI: 10.1016/j.redox.2020.101643
  • Peer Reviewed
• [Journal Article] Sequential Matrix Metalloproteinase-1 Expression Triggered by Infiltrating Monocytic Lineage Cells Modulates Pathophysiological Aspects of Human Nonalcoholic Steatohepatitis</p> (2020)
  • Author(s): Okazaki Isao、Shibata Shinsuke、Ando Wataru、Yanagawa Takayo、Yokomori Hiroaki、Sonoda Akira、Suzuki Norihiko、Yamanouchi Eigoro、Okada Shinya、Kamikura Shinichi、Hachimura Kazuaki、Takaki Takashi、Otori Katsuya、Suzuki Yutaka、Okano Hideyuki、Inagaki Yutaka
  • Journal Title: Metalloproteinases In Medicine Volume: Volume 7 Pages: 1-13
  • DOI: 10.2147/mnm.s252991
  • Peer Reviewed / Open Access
• [Journal Article] Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation (2020)
  • Author(s): Matsumura Seiichi、Kurashima Yosuke、Murasaki Sayuri、Morimoto Masako、Arai Fujimi、Saito Yukari、Katayama Nana、Kim Dayoung、Inagaki Yutaka、Kudo Takahiro、Ernst Peter B.、Shimizu Toshiaki、Kiyono Hiroshi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 18351-18351
  • DOI: 10.1038/s41598-020-75186-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of improved method to identify and analyze lung fibrocytes with flow cytometry in a reporter mouse strain (2020)
  • Author(s): Kawano Hiroshi、Koyama Kazuya、Nishimura Haruka、Toyoda Yuko、Kagawa Kozo、Sato Seidai、Naito Nobuhito、Goto Hisatsugu、Inagaki Yutaka、Nishioka Yasuhiko
  • Journal Title: Immunity, Inflammation and Disease Volume: 9 Issue: 1 Pages: 120-127
  • DOI: 10.1002/iid3.361
  • NAID: 120007180359
  • Peer Reviewed
• [Journal Article] 肝星細胞の活性化・脱活性化機構と肝線維症治療への展望 (2020)
  • Author(s): 中野泰博、稲垣 豊
  • Journal Title: 実験医学 Volume: 38 Pages: 1994-1999
• [Journal Article] A novel deactivation factor of fibrogenic hepatic stellate cells induces regression of liver fibrosis in mice (2020)
  • Author(s): Nakano Y, Kamiya A, Sumiyoshi H, Tsuruya K, Kagawa T, Inagaki Y.
  • Journal Title: Hepatology Volume: 71 Issue: 4 Pages: 1437-1452
  • DOI: 10.1002/hep.30965
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice (2019)
  • Author(s): Imai J, Yahata T, Ichikawa H, Ibrahim AA, Yazawa M, Sumiyoshi H, Inagaki Y, Matsushima M, Suzuki T, Mine T, Ando K, Miyata T, Hozumi K.
  • Journal Title: Intestinal Research Volume: 18 Issue: 2 Pages: 219-228
  • DOI: 10.5217/ir.2019.00037
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis (2019)
  • Author(s): Tsukui Tatsuya、Ueha Satoshi、Shichino Shigeyuki、Hashimoto Shinichi、Nakajima Takuya、Shiraishi Kazushige、Kihara Miho、Kiyonari Hiroshi、Inagaki Yutaka、Matsushima Kouji
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 514 Issue: 3 Pages: 684-690
  • DOI: 10.1016/j.bbrc.2019.05.011
  • Peer Reviewed / Open Access
• [Journal Article] CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells (2019)
  • Author(s): Ichikawa, T.*, Hirahara, K.*, Kokubo, K.*, Kiuchi, M., Aoki, A., Morimoto, Y., Kumagai, J., Onodera, A., Mato, N., Tumes, D., Goto, Y., Hagiwara, K., Inagaki, Y., Sparwasser, T., Tobe, K., and Nakayama, T.
  • Journal Title: Nature Immunology Volume: 20 Issue: 11 Pages: 1469-1480
  • DOI: 10.1038/s41590-019-0494-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis (2019)
  • Author(s): Asakawa M, Itoh M, Suganami T, Sakai T, Kanai S, Shirakawa I, Yuan X, Hatayama T, Shimada S, Akiyama Y, Fujiu K, Inagaki Y, Manabe I, Yamaoka S, Yamada T, Tanaka S, Ogawa Y.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 19601-19601
  • DOI: 10.1038/s41598-019-56039-0
  • Peer Reviewed / Open Access
• [Journal Article] Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells (2019)
  • Author(s): Kurashima Yosuke、Tokuhara Daisuke、Kamioka Mariko、Inagaki Yutaka、Kiyono Hiroshi
  • Journal Title: Frontiers in Immunology Volume: 10 Pages: 01281-01281
  • DOI: 10.3389/fimmu.2019.01281
  • Peer Reviewed / Open Access
• [Journal Article] 肝星細胞の脱活性化機構と肝線維化治療への応用 (2019)
  • Author(s): 中野泰博、稲垣 豊
  • Journal Title: 細胞 Volume: 51 Pages: 493-496
• [Journal Article] 肝線維化治療薬開発の現状と課題 (2019)
  • Author(s): 柳川享世、稲垣 豊
  • Journal Title: 肝胆膵 Volume: 79 Pages: 897-904
• [Journal Article] Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis. (2019)
  • Author(s): Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K.
  • Journal Title: JCI Insight. Volume: 4(1) Issue: 1 Pages: 122163-122163
  • DOI: 10.1172/jci.insight.122163
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a Novel Bone Marrow Cell-Derived Accelerator of Fibrotic Liver Regeneration Through Mobilization of Hepatic Progenitor Cells in Mice (2019)
  • Author(s): Yanagawa T, Sumiyoshi H, Higashi K, Nakao S, Higashiyama R, Fukumitsu H, Minakawa K, Chiba Y, Suzuki Y, Sumida K, Saito K, Kamiya A, Inagaki Y,
  • Journal Title: Stem Cells Volume: 37 Issue: 1 Pages: 89-101
  • DOI: 10.1002/stem.2916
  • Peer Reviewed / Open Access
• [Journal Article] Serum matrix metalloproteinase-1 level represents disease activity as opposed to fibrosis in patients with histologically proven nonalcoholic steatohepatitis (2018)
  • Author(s): Ando Wataru、Yokomori Hiroaki、Tsutsui Nobuhiro、Yamanouchi Eigoro、Suzuki Yutaka、Oda Masaya、Inagaki Yutaka、Otori Katsuya、Okazaki Isao
  • Journal Title: Clinical and Molecular Hepatology Volume: 24 Issue: 1 Pages: 61-76
  • DOI: 10.3350/cmh.2017.0030
  • Peer Reviewed
• [Journal Article] Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages. (2018)
  • Author(s): Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y.
  • Journal Title: PLoS One Volume: 13 Issue: 5 Pages: e0197604-e0197604
  • DOI: 10.1371/journal.pone.0197604
  • NAID: 120006605152
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Establishment and analyses of a mouse model that regulates sex-related differences in drug metabolism in the liver. (2018)
  • Author(s): Chikada H, Ida K, Ando E, Inagaki Y, Sakamoto A, Kamiya A.
  • Journal Title: Laboratory Investigation Volume: 98 Issue: 11 Pages: 1500-1511
  • DOI: 10.1038/s41374-018-0088-6
  • Peer Reviewed / Open Access
• [Journal Article] Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells (2018)
  • Author(s): Endo Hitoshi、Owada Satoshi、Inagaki Yutaka、Shida Yukari、Tatemichi Masayuki
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 10122-10122
  • DOI: 10.1038/s41598-018-28074-w
  • Peer Reviewed / Open Access
• [Journal Article] An in vitro model of polycystic liver disease using genome-edited human inducible pluripotent stem cells (2018)
  • Author(s): Kamiya Akihide、Chikada Hiromi、Ida Kinuyo、Ando Emi、Tsuruya Kota、Kagawa Tatehiro、Inagaki Yutaka
  • Journal Title: Stem Cell Research Volume: 32 Pages: 17-24
  • DOI: 10.1016/j.scr.2018.08.018
  • Peer Reviewed
• [Journal Article] Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis (2018)
  • Author(s): Souma Kunihiko、Shichino Shigeyuki、Hashimoto Shinichi、Ueha Satoshi、Tsukui Tatsuya、Nakajima Takuya、Suzuki Hiroshi I.、Shand Francis H. W.、Inagaki Yutaka、Nagase Takahide、Matsushima Kouji
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 16642-16642
  • DOI: 10.1038/s41598-018-34839-0
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a novel alpha-fetoprotein- expressing cell population induced by Jagged1/Notch2 signal in murine fibrotic liver. (2017)
  • Author(s): Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
  • Journal Title: Hepatol Commun Volume: 印刷中 Issue: 3 Pages: 1-15
  • DOI: 10.1002/hep4.1026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins (2017)
  • Author(s): Quadros RM, Miura H, Harms DW, Akatsuka H, Sato T, Aida T, Redder R, Richardson GP, Inagaki Y, Sakai D, Buckley SM, Seshacharyulu P, Batra SK, Behlke MA, Zeiner SA, Jacobi AM, Izu Y, Thoreson WB, Urness LD, Mansour SL, Ohtsuka M, Gurumurthy CB
  • Journal Title: Genome Biology Volume: 18 Issue: 1 Pages: 92-92
  • DOI: 10.1186/s13059-017-1220-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6. (2017)
  • Author(s): Ohkura SI, Usui S, Takashima SI, Takuwa N, Yoshioka K, Okamoto Y, Inagaki Y, Sugimoto N, Kitano T, Takamura M, Wada T, Kaneko S, Takuwa Y.
  • Journal Title: PLoS One. Volume: 12 Issue: 8 Pages: e0182329-e0182329
  • DOI: 10.1371/journal.pone.0182329
  • Peer Reviewed / Open Access
• [Journal Article] Adhesive and robust multi-layered poly(lactic acid) nanosheets for hemostatic dressing in liver injury model. (2017)
  • Author(s): Takuya Komachi, Hideaki Sumiyoshi, Yutaka Inagaki, Shinji Takeoka, Yu Nagase, Yosuke Okamura
  • Journal Title: J Biomed Mater Res Part B Volume: 印刷中 Issue: 7 Pages: 1-11
  • DOI: 10.1002/jbm.b.33714
  • Peer Reviewed / Open Access
• [Journal Article] Hepatic progenitor cell expansion in early-stage nonalcoholic steatohepatitis: evidence from immunohistochemistry and immunoelectron microscopy of matrix metalloproteinase-1. (2017)
  • Author(s): Hiroaki Yokomori, Masaya Oda, Wataru Ando, Yutaka Inagaki, Isao Okazaki
  • Journal Title: Med Mol Morphol Volume: 50 Issue: 4 Pages: 238-242
  • DOI: 10.1007/s00795-017-0162-y
  • Peer Reviewed
• [Presentation] 新たな再生医療の創生に向けたモニタリング用エクソソームの開発 (2021)
  • Author(s): 松木勇樹、住吉秀明、柳川享世、安田純平、後藤光昭、赤池敏宏、稲垣 豊
  • Organizer: 第20回日本再生医療学会総会
• [Presentation] 新規肝再生促進因子OGFRL1発現の臨床的意義 (2021)
  • Author(s): 柳川享世、中尾祥絵、鶴谷康太、加川建弘、松木勇樹、住吉秀明、稲垣 豊
  • Organizer: 第20回日本再生医療学会総会
• [Presentation] 肝星細胞による肝再生ニッチ構築の分子機構 (2020)
  • Author(s): 中野泰博、住吉秀明、稲垣 豊
  • Organizer: 第56回日本肝臓学会総会
• [Presentation] Notchリガンド・受容体の機能的差異による肝癌進展の制御機構 (2020)
  • Author(s): 中野泰博、伊藤 暢、宮島 篤、稲垣 豊
  • Organizer: 第27回肝細胞研究会
• [Presentation] 細胞ストレスと線維化－臓器特異性と共通性 (2020)
  • Author(s): 稲垣 豊
  • Organizer: 第20回分子予防環境医学研究会大会
  • Invited
• [Presentation] エクソソーム内包肝再生促進因子OGFRL1発現の臨床的意義 (2020)
  • Author(s): 柳川享世、中尾祥絵、住吉秀明、松木勇樹、紙谷聡英、鶴谷康太、加川建弘、岡崎 勲、稲垣 豊
  • Organizer: 第19回日本再生医療学会総会
• [Presentation] エクソソーム内包肝再生促進因子Opioid growth factor receptor-like 1の発現動態と臨床的意義 (2020)
  • Author(s): 柳川享世、鶴谷康太、加川建弘、紙谷聡英、岡崎 勲、稲垣 豊
  • Organizer: 第56回日本肝臓学会総会
• [Presentation] Ⅰ型プロコラーゲンのプロセシング、輸送および分泌過程の肝星細胞におけるライブイメージング解析 (2020)
  • Author(s): 守矢恒司、稲垣 豊、田中利明
  • Organizer: 第52回日本結合組織学会学術大会
• [Presentation] 非アルコール性脂肪性肝炎の病態制御機構における肝機能性差の関与 (2020)
  • Author(s): 紙谷聡英、井田絹代、稲垣 豊、近田裕美
  • Organizer: 第27回肝細胞研究会
• [Presentation] 急性ならびに慢性肝傷害におけるエクソソーム内包因子Opioid growth factor receptor-like1の発現意義 (2020)
  • Author(s): 柳川享世、中尾祥絵、住吉秀明、松木勇樹、紙谷聡英、加川建弘、鶴谷康太、横森昭弘、稲垣 豊
  • Organizer: 第27回肝細胞研究会
• [Presentation] エクソソーム治療法の創生に向けたモニタリング用エクソソームの開発 (2020)
  • Author(s): 松木勇樹、住吉秀明、柳川享世、安田純平、後藤光昭、赤池敏宏、稲垣 豊
  • Organizer: 第27回肝細胞研究会
• [Presentation] 難治性肝疾患に対するエクソソーム医療の創生に向けた技術開発 (2020)
  • Author(s): 松木勇樹、柳川享世、住吉秀明、稲垣 豊
  • Organizer: 第34回肝類洞壁細胞研究会学術集会
• [Presentation] エクソソーム内包肝再生因子OGFRL1発現の臨床的意義 (2020)
  • Author(s): 柳川享世、岡崎 勲、松木勇樹、住吉秀明、稲垣 豊
  • Organizer: 第34回肝類洞壁細胞研究会学術集会
• [Presentation] 造血系細胞が分泌するエクソソームを介した肝発生と傷害肝修復の制御機構 シンポジウム「エクソソームを介した肝病態の制御機構」 (2019)
  • Author(s): 柳川享世、住吉秀明、中尾祥絵、松木勇樹、紙谷聡英、近田裕美、大塚正人、三浦浩美、横森昭弘、高木孝士、稲垣 豊
  • Organizer: 第26回肝細胞研究会
• [Presentation] 効率性と安全性に優れた新規修飾型エクソソームの開発と薬物送達手段への応用 (2019)
  • Author(s): 松木勇樹、住吉秀明、柳川享世、中野泰博、後藤光昭、赤池敏宏、稲垣 豊
  • Organizer: 第26回肝細胞研究会
• [Presentation] 肝実質細胞と造血系細胞とのクロストークを介した肝発生と傷害肝修復の制御機構 ワークショップ１０「肝構成細胞の病態生理：基礎的研究の臨床応用」 (2019)
  • Author(s): 柳川享世、住吉秀明、紙谷聡英、横森弘昭、稲垣 豊
  • Organizer: 第55回日本肝臓学会総会
• [Presentation] Opioid growth factor receptor-like 1; an extracellular vesicle-derived common mediator of regeneration of fibrotic liver and fetal development of hepatic progenitor cells in mice (2019)
  • Author(s): Takayo Yanagawa, Hideaki Sumiyoshi, Sachie Nakao, Hiromi Miura, Masato Otsuka, Hiromi Chikada, Akihide Kamiya, Hiroaki Yokomori, Takashi Takaki, Yutaka Inagaki
  • Organizer: 20th International Symposium on Cells of the Hepatic Sinusoid
  • Int'l Joint Research
• [Presentation] Clinical significance of a novel exosomal protein, opioid growth factor receptor-like 1 in the repair from liver injury/fibrosis (2019)
  • Author(s): Takayo Yanagawa, Sachie Nakao, Akihide Kamiya, Hideaki Sumiyoshi, Yuki Matsui, Kota Tsuruya, Tatehiro Kagawa, Isao Okazaki, Yutaka Inagaki
  • Organizer: 70th Annual Meeting of the American Association for the Study of Liver Diseases
  • Int'l Joint Research
• [Presentation] エクソソーム内包タンパク質Opioid growth factor receptor like-1を介した肝発生と再生の制御機構 (2019)
  • Author(s): 柳川享世、中尾祥絵、住吉秀明、松木勇樹、岡崎 勲、横森弘昭、稲垣 豊
  • Organizer: 第33回肝類洞壁細胞研究会学術大会
• [Presentation] 効率性と安全性に優れたエクソソーム治療法の創生に向けたモニタリング用エクソソームの開発 (2019)
  • Author(s): 松木勇樹、住吉秀明、柳川享世、安田純平、中野泰博、後藤光昭、赤池敏宏、稲垣 豊
  • Organizer: 第33回肝類洞壁細胞研究会学術大会
• [Presentation] 血球由来エクソソーム内包タンパク質を介した胎仔肝芽細胞の分化制御． (2019)
  • Author(s): 柳川享世、住吉秀明、中尾祥絵、笠原大瑚、近田裕美、紙谷聡英、三浦浩美、大塚正人、横森弘昭、稲垣 豊
  • Organizer: 第18回日本再生医療学会総会
• [Presentation] 線維肝再生促進因子Opioid growth factor receptor-like 1に着目した肝硬変に対するエクソソーム医療の創出．シンポジウム３「肝線維化の基礎と臨床」 (2018)
  • Author(s): 柳川享世、住吉秀明、稲垣 豊
  • Organizer: 第54回日本肝臓学会総会
• [Presentation] Pathogenesis and treatment of liver fibrosis. (2018)
  • Author(s): Yutaka Inagaki
  • Organizer: International workshop on new micro technology and translational approaches for organ regeneration and cancer therapies.
  • Int'l Joint Research / Invited
• [Presentation] 新規再生促進因子Opioid growth factor receptor-like 1に着目したエクソソーム医療の基盤構築．ワークショップ「マトリックスと細胞機能」 (2018)
  • Author(s): 柳川享世、住吉秀明、中尾祥絵、笠原大瑚、近田裕美、紙谷聡英、横森昭弘、稲垣 豊
  • Organizer: 第50回日本結合組織学会学術大会
• [Presentation] エクソソーム内包肝再生促進因子を用いた肝不全治療の展望．シンポジウム２「肝不全治療への応用を目指したサイエンス－基礎と臨床から－」 (2018)
  • Author(s): 柳川享世、住吉秀明、中尾祥絵、松木勇樹、近田裕美、紙谷聡英、横森昭弘、稲垣 豊
  • Organizer: 第25回肝細胞研究会
• [Presentation] 肝線維化機序と治療戦略． (2018)
  • Author(s): 稲垣 豊
  • Organizer: 平成30年度日本肝臓学会 School of Hepatology
  • Invited
• [Presentation] エクソソーム内包タンパク質 Opioid growth factor receptor-like 1 を介した傷害肝再生機構の解明．シンポジウム２「形態学を基盤にした肝疾患研究の進歩と臨床応用」 (2018)
  • Author(s): 柳川享世、住吉秀明、中尾祥絵、笠原大瑚、松木勇樹、近田裕美、紙谷聡英、横森弘昭、稲垣 豊
  • Organizer: 第50回日本臨床分子形態学会学術集会
• [Presentation] Opioid growth factor receptor-like 1; an extracellular vesicle-mediated crosstalk between hematopoietic cells and hepatocytes that accelerates regeneration of murine fibrotic liver. (2018)
  • Author(s): Takayo Yanagawa, Hideaki Sumiyoshi, Sachie Nakao, Daigo Kasahara, Hiromi Miura, Masato Otsuka, Hiromi Chikada, Akihide Kamiya, Hiromi Chikada, Hiroaki Yokomori, Yutaka Inagaki
  • Organizer: American Association for the Study of Liver Diseases Single Topic Conference 2019: Hepatic Fibrosis, New Concept and Controversies.
  • Int'l Joint Research
• [Presentation] NASHにおける肝線維化の進展機構．シンポジウム２「肥満合併症としての肝疾患－NASHと肝細胞癌をどう捉えるか－」 (2018)
  • Author(s): 稲垣 豊、茂呂 忠
  • Organizer: 第39回日本肥満学会
  • Invited
• [Presentation] エクソソーム内包新規再生促進因子に着目した線維肝に対する再生治療戦略． (2018)
  • Author(s): 稲垣 豊、柳川享世、住吉秀明
  • Organizer: 第17回日本再生医療学会総会
  • Invited
• [Presentation] エクソソーム内包タンパク質Opioid growth factor receptor-like 1を介した肝再生機構の解明． (2018)
  • Author(s): 柳川享世、住吉秀明、中尾祥絵、笠原大瑚、近田裕美、紙谷聡英、横森弘昭、稲垣 豊
  • Organizer: 第17回日本再生医療学会総会
• [Presentation] 線維肝の再生と胎仔肝の発生を制御するOpioid growth factor recepter-like1の作用機構． (2017)
  • Author(s): 柳川享世、住吉秀明、紙谷聡英、稲垣 豊
  • Organizer: 第53回日本肝臓学会総会
• [Presentation] 線維肝の修復と再生を司る分子機構． (2017)
  • Author(s): 柳川享世、住吉秀明、千葉陽介、鈴木悠平、中尾祥絵、近田裕美、紙谷聡英、稲垣 豊
  • Organizer: 第49回日本結合組織学会学術大会
• [Presentation] 線維肝の再生における肝前駆細胞の動員に寄与する Opioid growth factor receptor-like 1の機能解析． (2017)
  • Author(s): 柳川享世、住吉秀明、中尾祥絵、近田裕美、紙谷聡英、稲垣 豊
  • Organizer: 第24回肝細胞研究会
• [Presentation] 病態の基礎－肝の線維化と再生． (2017)
  • Author(s): 稲垣 豊
  • Organizer: 平成29年度日本肝臓学会教育講演会
  • Invited
• [Presentation] Opioid growth factor receptor-like 1; an extracellular vesicle-mediated signal between hematopoietic cells and hepatic parenchymal cells that regulates repair and embryonic development of the liver. (2017)
  • Author(s): Takayo Yanagawa, Hideaki Sumiyoshi, Sachie Nakao, Hiromi Chikada, Akihide Kamiya, Daigo Kasahara, Hiromi Chikada, Akihide Kamiya, Yutaka Inagaki
  • Organizer: 68th Annual Meeting of the American Association for the Study of Liver Diseases
  • Int'l Joint Research
• [Remarks] 東海大学大学院 マトリックス医学生物学センター
  • URL: http://matrix.med.u-tokai.ac.jp/
• [Remarks] 東海大学大学院 医学研究科
  • URL: http://www.med.u-tokai.ac.jp/daigakuin/web/matrix.html
• [Remarks] 東海大学大学院 マトリックス医学生物学センター
  • URL: http://matrix.med.u-tokai.ac.jp/index.html
• [Patent(Industrial Property Rights)] Method for determining tissue regeneration state of living body organs (2018)
  • Inventor(s): 稲垣 豊、柳川享世、角中ちひろ、小田健太、鈴木誓吾
  • Industrial Property Rights Holder: 稲垣 豊、柳川享世、角中ちひろ、小田健太、鈴木誓吾
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Overseas
• [Patent(Industrial Property Rights)] 成体の組織再生状態の判定方法 (2017)
  • Inventor(s): 稲垣 豊、柳川享世、角中ちひろ、小田健太、鈴木誓吾
  • Industrial Property Rights Holder: 稲垣 豊、柳川享世、角中ちひろ、小田健太、鈴木誓吾
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-176103
  • Filing Date: 2017
• [Funded Workshop] Tokai University-USC Workshop on Steatohepatitis, Liver Fibrosis and HCC (2018)