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Ninj1-mediated vascular maturation and development of therapeutic strategy for atherosclerosis

Research Project

Project/Area Number 17H04170
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cardiovascular medicine
Research InstitutionAsahikawa Medical College

Principal Investigator

Kawabe Jun-ichi  旭川医科大学, 医学部, 教授 (10400087)

Co-Investigator(Kenkyū-buntansha) 松永 行子 (津田行子)  東京大学, 生産技術研究所, 准教授 (00533663)
甲賀 大輔  旭川医科大学, 医学部, 准教授 (30467071)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords動脈硬化 / 血管新生 / 神経再生 / 体性幹細胞 / 周細胞 / 血管安定化 / 毛細血管 / 神経再生能 / 神経血管伴走 / angiogenesis / atherosclerosis / pericytes / 末梢神経 / renervation
Outline of Final Research Achievements

Atherosclerosis is a fundamental condition for cardiovascular diseases. It is well recognized that atherosclerotic events are initiated by damage in inner side of vascular walls. We found that in addition to inner side, event in adventitial side, especially abnormality in the formation of microvasculature closely contribute to progression of atherosclerotic plaque. We also found that abnormality of microvascular formation is due to an interaction of PCs and EC tubes and perivascular wiring of peripheral nerve.

Academic Significance and Societal Importance of the Research Achievements

動脈硬化の病態の場所が、従来から注目されている内膜だけでなく、外膜部(特に微小血管形成異常)にもある、さらに、この微小血管形成異常の機序を明らかにすることにより、従来の動脈硬化治療で克服できなかった「高齢化社会下での動脈硬化」治療戦略の一つの方向性を示せた。また、新生血管の成熟化と平行して、神経線維の伴走化する知見を得たことにより、微小血管形成制御だけでなく、神経再生の機序解明に繋がる糸口となった。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (12 results)

All 2020 2019 2018 2017

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Capillary-resident EphA7(+) pericytes are multipotent cells with anti-ischemic effects through capillary formation.2020

    • Author(s)
      Yoshida Y, Kabara M, Kano K, Horiuchi K, Hayasaka T, Tomita Y, Takehara N, Minoshima A, Aonuma T, Maruyama K, Nakagawa N, Azuma N, Hasebe N, Kawabe JI.
    • Journal Title

      Stem Cells Transl Med

      Volume: 9 Issue: 1 Pages: 120-130

    • DOI

      10.1002/sctm.19-0148

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ninjurin 1 mediates peripheral nerve regeneration through Schwann cell maturation of NG2-positive cells2019

    • Author(s)
      Tomita Yui、Horiuchi Kiwamu、Kano Kohei、Tatsukawa Takamitsu、Matsuo Risa、Hayasaka Taiki、Yoshida Yuri、Kabara Maki、Yasuda Satoshi、Nakajima Keiichi、Nakagawa Naoki、Takehara Naofumi、Okizaki Atsutaka、Hasebe Naoyuki、Kawabe Jun-ichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 519 Issue: 3 Pages: 462-468

    • DOI

      10.1016/j.bbrc.2019.09.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pericyte-Specific Ninjurin1 Deletion Attenuates Vessel Maturation and Blood Flow Recovery in Hind Limb Ischemia.2018

    • Author(s)
      Minoshima A, Hasebe N et al
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 38 Issue: 10 Pages: 2358-2370

    • DOI

      10.1161/atvbaha.118.311375

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A 3D in vitro pericyte-supported microvessel model: visualization and quantitative characterization of multistep angiogenesis.2018

    • Author(s)
      Lee, E, Takahashi H, Pauty J, Kobayashi M, Kato K, Kabara M, Kawabe J, Matunaga YT
    • Journal Title

      J Material Chem B.

      Volume: 6 Pages: 1085-94

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 周細胞特異的Ninjurin1欠損は血管外膜vasa vasorumの形成異常と血管内膜肥厚の増悪をもたらす2019

    • Author(s)
      堀内至、蓑島暁帆、鹿原真樹、早坂太希、吉田有里、鹿野耕平、富田唯、松木孝樹、齋藤幸裕、丸山啓介、澤田潤、中川直樹、竹原有史、長谷部直幸、川辺淳一
    • Organizer
      第48回日本心脈管作動物質学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Ninj1 mediates neovessel maturation through angiopoietin 1 expression by pericytes2018

    • Author(s)
      Minoshima, Kawabe J, Matsuki M, Kabara M, Horiuchi K, Hayasaka, T< Shimamura K , Takehara N, Hasebe N.
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Deletion of pericyte-specific Ninjurin1 inhibits the formation of matured vessels in ischemic tissues and attenuated the blood flow recovery in the hind limb ischemia2018

    • Author(s)
      K Horiuchi, A Minoshima, M Kabara, T Hayasaka, N Takehara, N Hasebe, J Kawabe
    • Organizer
      第2回 日本循環器学会基礎研究フォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of Capillary stem cells having capillary formation and potent regenerative potency2018

    • Author(s)
      吉田 有里 、鹿原 真樹 、鹿野 耕平 、早坂 太希 、富田 唯 、堀内 至 、簑島 暁帆 、齊藤 幸裕 、西村 正人 、竹原 有史 、東 信良 、長谷部 直幸 、川辺 淳一
    • Organizer
      第1回日本循環器基礎研究フォーラムBCVR
    • Related Report
      2018 Annual Research Report
  • [Presentation] Capillary stem cells, multipotent pericytes resident in microvessels and their clinical application2018

    • Author(s)
      Kawabe J
    • Organizer
      第41回  日本分子生物学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Capillary pericytes provide a new insight in vital phenomenon of multicellular organism.2018

    • Author(s)
      Kawabe J
    • Organizer
      第41回  日本高血圧学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Ninjurin1 mediates vessel maturation through endothelial-pericytes interactions and enhances the blood flow recovery in the hind limb ischemia.2017

    • Author(s)
      Minoshima, Kawabe et al
    • Organizer
      第81回 日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ninjurin1 mediates vessel maturation through endothelial-pericytes interactions and enhances the blood flow recovery in the hind limb ischemia.2017

    • Author(s)
      Minoshima, Kawabe et al
    • Organizer
      European Society of Cardiology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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