Ninj1-mediated vascular maturation and development of therapeutic strategy for atherosclerosis
| Project/Area Number |
17H04170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松永 行子 (津田行子) 東京大学, 生産技術研究所, 准教授 (00533663)
甲賀 大輔 旭川医科大学, 医学部, 准教授 (30467071)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 動脈硬化 / 血管新生 / 神経再生 / 体性幹細胞 / 周細胞 / 血管安定化 / 毛細血管 / 神経再生能 / 神経血管伴走 / angiogenesis / atherosclerosis / pericytes / 末梢神経 / renervation |
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| Outline of Final Research Achievements |
Atherosclerosis is a fundamental condition for cardiovascular diseases. It is well recognized that atherosclerotic events are initiated by damage in inner side of vascular walls. We found that in addition to inner side, event in adventitial side, especially abnormality in the formation of microvasculature closely contribute to progression of atherosclerotic plaque. We also found that abnormality of microvascular formation is due to an interaction of PCs and EC tubes and perivascular wiring of peripheral nerve.
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| Academic Significance and Societal Importance of the Research Achievements |
動脈硬化の病態の場所が、従来から注目されている内膜だけでなく、外膜部（特に微小血管形成異常）にもある、さらに、この微小血管形成異常の機序を明らかにすることにより、従来の動脈硬化治療で克服できなかった「高齢化社会下での動脈硬化」治療戦略の一つの方向性を示せた。また、新生血管の成熟化と平行して、神経線維の伴走化する知見を得たことにより、微小血管形成制御だけでなく、神経再生の機序解明に繋がる糸口となった。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Capillary-resident EphA7(+) pericytes are multipotent cells with anti-ischemic effects through capillary formation.2020
Author(s)
Yoshida Y, Kabara M, Kano K, Horiuchi K, Hayasaka T, Tomita Y, Takehara N, Minoshima A, Aonuma T, Maruyama K, Nakagawa N, Azuma N, Hasebe N, Kawabe JI.
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Journal Title
Stem Cells Transl Med
Volume: 9
Issue: 1
Pages: 120-130
DOI
Related Report
Peer Reviewed / Open Access
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