Elucidation of transcriptional and epigenomic regulation for maintaining normal cardiac function

• Project/Area Number: 17H04174
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Shinshu University
• Principal Investigator: Kuwahara Koichiro 信州大学, 学術研究院医学系, 教授 (30402887)
• Co-Investigator(Kenkyū-buntansha): 木下 秀之 京都大学, 医学研究科, 特定准教授 (30467477) ; 中川 靖章 京都大学, 医学研究科, 助教 (70452357)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 心不全 / エピゲノム / 転写因子 / 遺伝子 / 分子心臓病学 / シグナル伝達 / 心臓病 / 転写調節 / 分子心臓学 / シグナル伝達経路 / 循環器・高血圧 / 発現制御

Outline of Final Research Achievements

We studied the role played by transcriptional and epigenomic factors in the development of heart failure. We revealed the role of GNAO1 gene in NRSF-HDAC complex-mediated maintaining cardiac function. We also analyzed phenotypes of mice with cardiac specific deletion of HDAC1/2, LSD1 and G9a. We also addressed the possible importance of MRTF-A, a rho-dependent co-activator of SRF, and lamin in regulating cardiac gene transcription and cardiac function.

Academic Significance and Societal Importance of the Research Achievements

慢性心不全は予後不良の疾患症候群であり、高齢化および生活環境の変化に伴い患者数の増加が問題となっており、その病態解明に基づく新規予防・治療法開発が望まれている。本研究は、心不全あるいはそれに至る過程における心筋遺伝子発現変化の分子メカニズムの一端を明らかにし、慢性心不全の発症・進展に深く関わる分子機序の解明、さらには心不全に対する新規治療標的の探索に貢献しえるものと考えている。

Research Products

• [Int'l Joint Research] Texas Southwestern Medical Center/Michigan State University/UCSF(米国)
• [Int'l Joint Research] University of Texas/NIEHS/Michigan State University(米国)
• [Int'l Joint Research] Max-Planck-Institute(ドイツ)
• [Int'l Joint Research] Michigan State University/University of Texas(米国)
• [Int'l Joint Research] Academic Medical Center(Netherlands)
• [Journal Article] Impact of Therapeutic Angiogenesis Using Autologous Bone Marrow-Derived Mononuclear Cells Implantation in Critical Limb Ischemia With Scleroderma ― Subanalysis of the Long-Term Clinical Outcomes Survey ― (2019)
  • Author(s): Shoji K, Yanishi K, Yoshimi R, Hamada N, Kondo K, Fujimoto K, Nakajima H, Kuwahara K, Higashi Y, Fukumoto Y, Murohara T, Matoba S; TACT Follow up Study Investigators
  • Journal Title: Circulation Journal Volume: 83 Issue: 3 Pages: 662-671
  • DOI: 10.1253/circj.CJ-18-1044
  • NAID: 130007603957
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-02-25
  • Peer Reviewed / Open Access
• [Journal Article] Establishment of a Healthcare System for Patients With Adult Congenital Heart Disease in Collaboration With Children’s Hospital ― The Nagano Model ― (2019)
  • Author(s): Motoki H, Yasukochi S, Takigiku K, Takei K, Okamura T, Kimura K, Minamisawa M, Okada A, Saigusa T, Ebisawa S, Seto T, Shoda M, Okada K, Kuwahara K
  • Journal Title: Circulation Journal Volume: 83 Issue: 2 Pages: 424-431
  • DOI: 10.1253/circj.CJ-18-0705
  • NAID: 130007557007
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-01-25
  • Peer Reviewed / Open Access
• [Journal Article] Atrial and brain natriuretic peptides: Hormones secreted from the heart (2019)
  • Author(s): Nakagawa Y, Nishikimi T, Kuwahara K.
  • Journal Title: Peptides Volume: 111 Pages: 18-25
  • DOI: 10.1016/j.peptides.2018.05.012
  • NAID: 120006817603
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of leg loader and treadmill exercise for evaluating patients with peripheral artery disease (2019)
  • Author(s): Ueki Y, Miura T, Mochidome T, Senda K, Ebisawa S, Saigusa T, Motoki H, Okada A, Koyama J, Kuwahara K.
  • Journal Title: Heart Vessels Volume: 34 Issue: 4 Pages: 590-596
  • DOI: 10.1007/s00380-018-1274-6
  • Peer Reviewed / Open Access
• [Journal Article] Utility of copeptin for predicting long-term clinical outcomes in patients with heart failure (2019)
  • Author(s): Yoshikawa Yusuke、Shiomi Hiroki、Kuwahara Koichiro、Sowa Naoya、Yaku Hidenori、Yamashita Yugo、Tazaki Junichi、Imai Masao、Kato Takao、Saito Naritatsu、Shizuta Satoshi、Ono Koh、Kimura Takeshi
  • Journal Title: Journal of Cardiology Volume: 73 Issue: 5 Pages: 379-385
  • DOI: 10.1016/j.jjcc.2018.11.008
  • Peer Reviewed
• [Journal Article] Role of echocardiography in assessing cardiac amyloidoses: a systematic review (2019)
  • Author(s): Jun Koyama et al.
  • Journal Title: Journal of Echocardiography Volume: - Issue: 2 Pages: 64-75
  • DOI: 10.1007/s12574-019-00420-5
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia (2019)
  • Author(s): Oshita K, Kozasa Y, Nakagawa Y, Kuwabara Y, Kuwahara K, Nakagawa T, Nakashima N, Hiraki T, Takano M
  • Journal Title: The Journal of Physiological Sciences Volume: in press Issue: 4 Pages: 653-660
  • DOI: 10.1007/s12576-019-00684-7
  • NAID: 40021916400
  • Peer Reviewed / Open Access
• [Journal Article] MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages (2019)
  • Author(s): An J, Naruse K T, Hinohara K, Soejima Y, Sawabe M, Nakagawa Y, Kuwahara K, Kimura A.
  • Journal Title: Journal of Molecular and cellular cardiology Volume: 133 Pages: 26-35
  • DOI: 10.1016/j.yjmcc.2019.05.015
  • NAID: 130007811832
  • Peer Reviewed / Open Access
• [Journal Article] Association of Mineralocorticoid Receptor Antagonist Use With All-Cause Mortality and Hospital Readmission in Acute Decompensated Heart Failure. (2019)
  • Author(s): Yaku H, Kato T, Morimoto T, Inuzuka Y, Tamaki Y, Ozasa N, Yamamoto E, Yoshikawa Y, Kitai T, Taniguchi R, Iguchi M, Kato M, Takahashi M, Jinnai T, Ikeda T, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Toyofuku M, Seko Y, Furukawa Y, et al.
  • Journal Title: JAMA Netw Open. Volume: Jun 5;2(6) Issue: 6 Pages: e195892-e195892
  • DOI: 10.1001/jamanetworkopen.2019.5892
  • Peer Reviewed / Open Access
• [Journal Article] Impact of inpatient cardiac rehabilitation on Barthel Index score and prognosis in patients with acute decompensated heart failure (2019)
  • Author(s): Motoki Hirohiko、Nishimura Musashi、Kanai Masafumi、Kimura Kazuhiro、Minamisawa Masatoshi、Yamamoto Shuhei、Saigusa Tatsuya、Ebisawa Soichiro、Okada Ayako、Kuwahara Koichiro
  • Journal Title: International Journal of Cardiology Volume: 293 Pages: 125-130
  • DOI: 10.1016/j.ijcard.2019.06.071
  • Peer Reviewed
• [Journal Article] Association between reactive hyperemia peripheral arterial tonometry index and atrial fibrillation recurrence after catheter ablation. (2019)
  • Author(s): Kobayashi H, Okada A, Tabata H, Shoin W, Okano T, Yoshie K, Oguchi Y, Kato K, Shoda M, Kuwahara K
  • Journal Title: Int J Cardiol Heart Vasc Volume: 24 Pages: 100385-100385
  • DOI: 10.1016/j.ijcha.2019.100385
  • Peer Reviewed / Open Access
• [Journal Article] Demographics, Management, and In-Hospital Outcome of Hospitalized Acute Heart Failure Syndrome Patients in Contemporary Real Clinical Practice in Japan ― Observations From the Prospective, Multicenter Kyoto Congestive Heart Failure (KCHF) Registry ― (2018)
  • Author(s): Yaku H, Ozasa N, Morimoto T, Inuzuka Y, Tamaki Y, Yamamoto E, Sato Y, Kuwahara K, Kato T, Kimura T, et al; KCHF Study Investigators.
  • Journal Title: Circulation Journal Volume: 82 Issue: 11 Pages: 2811-2819
  • DOI: 10.1253/circj.CJ-17-1386
  • NAID: 120006534610
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-10-25
  • Peer Reviewed / Open Access
• [Journal Article] Cutting Edge of Brain Natriuretic Peptide (BNP) Research ― The Diversity of BNP Immunoreactivity and Its Clinical Relevance ― (2018)
  • Author(s): Kuwahara K, Nakagawa Y, Nishikimi T.
  • Journal Title: Circulation Journal Volume: 82 Issue: 10 Pages: 2455-2461
  • DOI: 10.1253/circj.CJ-18-0824
  • NAID: 130007489414
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-09-25
  • Peer Reviewed / Open Access
• [Journal Article] Geriatric Nutritional Risk Index Predicts Cardiovascular Events in Patients at Risk for Heart Failure (2018)
  • Author(s): Minamisawa M, Miura T, Motoki H, Ueki Y, Nishimura H, Shimizu K, Shoin W, Harada M, Mochidome T, Senda K, Yoshie K, Oguchi Y, Hashizume N, Abe N, Saigusa T, Ebisawa S, Izawa A, Koyama J, Ikeda U, Kuwahara K
  • Journal Title: Circulation Journal Volume: 82 Issue: 6 Pages: 1614-1622
  • DOI: 10.1253/circj.CJ-17-0255
  • NAID: 130006744280
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-05-25
  • Peer Reviewed / Open Access
• [Journal Article] Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence. (2018)
  • Author(s): Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.
  • Journal Title: Sci Signal Volume: 11 Issue: 556 Pages: 5185-5195
  • DOI: 10.1126/scisignal.aat5185
  • Peer Reviewed / Open Access
• [Journal Article] Cross-sectional study of the association between day-to-day home blood pressure variability and visceral fat area measured using the dual impedance method. (2018)
  • Author(s): Kuwabara J, Kuwahara K, Kuwabara Y, Yasuno S, Nakagawa Y, Ueshima K, Kimura T
  • Journal Title: PLoS One. Volume: 13 Issue: 11 Pages: e0206945-e0206945
  • DOI: 10.1371/journal.pone.0206945
  • NAID: 120006539573
  • Peer Reviewed / Open Access
• [Journal Article] Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death. (2018)
  • Author(s): Fujii T, Hirota K, Yasoda A, Takizawa A, Morozumi N, Nakamura R, Yotsumoto T, Kondo E, Yamashita Y, Sakane Y, Kanai Y, Ueda Y, Yamauchi I, Yamanaka S, Nakao K, Kuwahara K, Jindo T, Furuya M, Mashimo T, Inagaki N, Serikawa T, Nakao K.
  • Journal Title: PROS ONE Volume: 13 Issue: 3 Pages: e0194812-e0194812
  • DOI: 10.1371/journal.pone.0194812
  • NAID: 120006466606
  • Peer Reviewed / Open Access
• [Journal Article] Single-center experience with percutaneous lead extraction of cardiac implantable electric devices. (2018)
  • Author(s): Okada A, Shoda M, Tabata H, Shoin W, Kobayashi H, Okano T, Yoshie K, Oguchi Y, Takeuchi T, Kato K, Kuwahara K
  • Journal Title: J Cardiol Volume: 71 Issue: 2 Pages: 192-196
  • DOI: 10.1016/j.jjcc.2017.07.011
  • Peer Reviewed / Open Access
• [Journal Article] Drug-Eluting versus Bare-Metal Stent Implantation with or without Cilostazol in the Treatment of the Superficial Femoral Artery The DEBATE in SFAStudy. (2018)
  • Author(s): Miura T, Miyashita Y, Soga Y, Hozawa K, Doijiri T, Ikeda U, Kuwahara K.
  • Journal Title: Circ Cardiovasc Interv Volume: 11 Issue: 8
  • DOI: 10.1161/circinterventions.118.006564
  • Peer Reviewed / Open Access
• [Journal Article] Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease (2018)
  • Author(s): 7.Minamisawa M, Koyama J, Kozuka A, Miura T, Saigusa T, Ebisawa S, Motoki H, Okada A, Ikeda U, Kuwahara K
  • Journal Title: Open Heart. Volume: 5 Issue: 2 Pages: e000896-e000896
  • DOI: 10.1136/openhrt-2018-000896
  • Peer Reviewed / Open Access
• [Journal Article] Macro-pro-B-type natriuretic peptide (proBNP) and hidden macro-N-terminal proBNP:Case report. (2017)
  • Author(s): Nakagawa Y, Nishikimi T, Sakai H, Ohno S, Kinoshita H, Inazumi H, Moriuchi K, Kuwahara K, Horie M, Kimura T.
  • Journal Title: Clinical Biochemistry Volume: 52 Pages: 148-152
  • DOI: 10.1016/j.clinbiochem.2017.10.019
  • Peer Reviewed
• [Journal Article] Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model. (2017)
  • Author(s): Ogasawara T, Okano S, Ichimura H, Kadota S, Tanaka Y, Minami I, Uesugi M, Wada Y, Saito N, Okada K, Kuwahara K, Shiba Y
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 8630-8630
  • DOI: 10.1038/s41598-017-09217-x
  • Peer Reviewed / Open Access
• [Journal Article] Kyoto Congestive Heart Failure (KCHF) Study: Rationale and Design (2017)
  • Author(s): Yamamoto E, Kato T, Ozasa N, Yaku H, Inuzuka Y, Tamaki Y, Kitai T, Morimoto T, Taniguchi R, Iguchi M, Kato M, Takahashi M, Jinnai T, Ikeda T, Nagao K, Kawai T, Komasa A,Nishikawa R, Kawase Y, Morinaga T,Kawashima T, Motohashi Y, Kawato M, Toyofuku M, Sato Y, Kuwahara K, et al.
  • Journal Title: ESC Heart Fail Volume: 4 Issue: 3 Pages: 216-223
  • DOI: 10.1002/ehf2.12138
  • NAID: 120007100124
  • Peer Reviewed / Open Access
• [Journal Article] Impressive predictive value of ankle-brachial index for very long-term outcomes in patients with cardiovascular disease: IMPACT-ABI study. (2017)
  • Author(s): Miura T, Minamisawa M, Ueki Y, Abe N, Nishimura H, Hashizume N, Mochidome T, Harada M, Oguchi Y, Yoshie K, Shoin W, Saigusa T, Ebisawa S, Motoki H, Koyama J, Ikeda U, Kuwahara K.
  • Journal Title: PLoS One Volume: 12 Issue: 6 Pages: e0177609-e0177609
  • DOI: 10.1371/journal.pone.0177609
  • Peer Reviewed / Open Access
• [Journal Article] B-Type Natriuretic Peptide in Heart Failure With Preserved Ejection Fraction ― Relevance to Age-Related Left Ventricular Modeling in Japanese ― (2017)
  • Author(s): Tanabe N, Ikeda S, Tahara N, Fukuda K, Hatano M, Ito H, Nakayama T, Anzai T, Hashimoto A, Inoue T, Kajinami K, Kihara Y, Kinoshita H, Kuwahara K, Murohara T, Okazaki O, Sakai S, Satoh T, Takeda Y, Takeishi Y, Taniguchi M, Watanabe H, Yamamoto T, Yamauchi-Takihara K, Yoshioka K, Sasayama S.
  • Journal Title: Circulation Journal Volume: 81 Issue: 7 Pages: 1006-1013
  • DOI: 10.1253/circj.CJ-16-1282
  • NAID: 130006887044
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts. (2017)
  • Author(s): Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
  • Journal Title: J Am Heart Assoc. Volume: 6 Issue: 2
  • DOI: 10.1161/jaha.116.003601
  • NAID: 120007100125
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endothelium-derived C-type natriuretic peptide contributes to blood pressure regulation by maintaining endothelial integrity. (2017)
  • Author(s): Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Minami T, Kuwabara Y, Yamada C, Yamada Y, Tokudome T, Nagai-Okatani C, Minamino N, Nakao YM, Yasuno S, Ueshima K, Sone M, Kimura T, Kangawa K, Nakao K
  • Journal Title: Hypertension. Volume: 69 Issue: 2 Pages: 286-296
  • DOI: 10.1161/hypertensionaha.116.08219
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy. (2017)
  • Author(s): Mori KP, Yokoi H, Kasahara M, Imamaki H, Ishii A, Kuwabara T, Koga K, Kato Y, Toda N, Ohno S, Kuwahara K, Endo T, Nakao K, Yanagita M, Mukoyama M, Mori K.
  • Journal Title: J Am Soc Nephrol. Volume: 28 Issue: 1 Pages: 278-289
  • DOI: 10.1681/asn.2015101168
  • NAID: 120005820888
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cardiac hyaluronan may be associated with the persistence of atrial fibrillation (2017)
  • Author(s): Okada Ayako、Kashima Yuichiro、Tomita Takeshi、Takeuchi Takahiro、Oguchi Yasutaka、Yoshie Koji、Shoin Wataru、Shoda Morio、Nitta Kenichi、Kuwahara Koichiro、Imamura Hiroshi
  • Journal Title: Heart and Vessels Volume: 32 Issue: 9 Pages: 1144-1150
  • DOI: 10.1007/s00380-017-0972-9
  • Peer Reviewed
• [Presentation] Impact of electrical reverse remodeling by cardiac resynchronization therapy on adverse cardiac events in patients of heart failure with reduced ejection fraction. (2020)
  • Author(s): Kobayashi H, Okada A, Tabata H, Shoin W, Okano T, Yoshie K, Shoda M, Kuwahara K.
  • Organizer: uropean Heart Rhythm Association Congress (EHRA) 2020
  • Int'l Joint Research
• [Presentation] The impact of residual SYNTAX score after endovascular treatment peripheral artery disease (2020)
  • Author(s): Kato T, Miura T, ,Motoki H, Kuwahara K, et al.
  • Organizer: The Leipzig Interventional Course(LINC)2020
  • Int'l Joint Research
• [Presentation] Increased Gao expression underlies cardiac dysfunction and lethal arrhythmias accompanied with abnormal Ca2+ handling (2019)
  • Author(s): Inazumi H, Kuwahara K, Kuwabara Y, Nakagawa Y, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Oya M, Yamada M, Kashihara T, Kurebayashi N, Sugihara M, Nakao K, Kimura T.
  • Organizer: ESC Congress 2019
  • Int'l Joint Research
• [Presentation] 抑制性Ｇ蛋白サブユニットＧαoの発現亢進はCa2+ handlingの異常を介して心不全進展にかかわる (2019)
  • Author(s): 稲住英明 桑原宏一郎 桒原佳宏 中川靖章 木下秀之 森内健史 柳澤洋 錦見俊雄 大矢未来 山田充彦 柏原俊英 呉林なごみ 中尾一和 木村剛
  • Organizer: 第56回日本臨床分子医学会学術集会
• [Presentation] athological roles of TRP channels in heart failure (2019)
  • Author(s): Kuwahara K
  • Organizer: ISHR World Congress 2019
  • Int'l Joint Research / Invited
• [Presentation] Clinical Characteristics of Late Catch-up Phenomenon after Implantation of 2nd Generation Drug Eluting Stent from SHINANO 5years Registry. (2019)
  • Author(s): Saigusa T, Miura T, Taki M, Kobayashi M, Kanai M, Okuma Y, Yanagisawa T, Hashizume N, Otagiri K, Shoin K, Nagae A, Sakai T, Senda K, Kato T, Ebisawa S, Miyashita Y, Motoki H, Kuwahara K.
  • Organizer: ESC Congress 2019
  • Int'l Joint Research
• [Presentation] Impact of Left Ventricular Ejection Fraction in Patients with Peripheral Artery Disease : From I-PAD Registry (2019)
  • Author(s): Fujimori K, Nagae A, Kuwahara K, et al.
  • Organizer: ESC Congress 2019
  • Int'l Joint Research
• [Presentation] Arrest of progression of cardiac amyloidosis after chemotherapy predicts favorable outcome in patients with light-chain amyloidosis (2019)
  • Author(s): Koyama J, Minamisawa M, Kuwahara K
  • Organizer: ESC Asia with APSC&AFC
  • Int'l Joint Research
• [Presentation] Increased Gαo expression plays a pivotal role in the progression of heart failure by impairing Ca2+ handling (2019)
  • Author(s): Hideaki Inazumi, Koichiro Kuwahara, Yoshihiro Kuwabara, Yasuaki Nakagawa, Hideyuki Kinoshita、Kenji Moriuchi, Hiromu Yanagisawa, Toshio Nishikimi,Kazuwa Nakao, Takeshi Kimura
  • Organizer: BCVS2019
  • Int'l Joint Research
• [Presentation] 機械弁症例の周産期管理 (2019)
  • Author(s): 元木博彦
  • Organizer: 日本心エコー図学会第30回学術集会
• [Presentation] 成人フォンタン患者の心エコーの役割． (2019)
  • Author(s): 元木博彦
  • Organizer: 日本心エコー図学会第30回学術集会
  • Invited
• [Presentation] Increased expression of Gαo plays a pivotal role in the progression of heart failure by impairing Ca2+ homeostasis (2019)
  • Author(s): H Inazumi, K Kuwahara, Y Kuwabara, Y Nakagawa, H Kinoshita, K Moriuchi, H Yanagisawa , T Nishikimi , M Oya, M Yamada, T Kashihara, N Kurebayashi, M Sugihara, K Nakao, T Kimura
  • Organizer: 第36回国際心臓研究学会日本部会
• [Presentation] Prevalence of critical limb ischemia and peripheral arterial disease in patients with end-stage renal disease on hemodialysis due to diabetic nephropathy, from PREDICT study. (2018)
  • Author(s): Kato T, Kuwahara K, et al.
  • Organizer: The Leipzig Interventional Course(LINC)2018
  • Int'l Joint Research
• [Presentation] Potentiality of sheathless naked stent delivery technique on the puncture complications in patients with peripheral artery disease. (2018)
  • Author(s): Mochidome T, Miura T, Sakai T, Senda K, Saigusa T, Ebisawa S, Motoki H, Okada A, Kuwahara K
  • Organizer: The Leipzig Interventional Course(LINC)2018
  • Int'l Joint Research
• [Presentation] Characteristic and Clinical Outcomes in Patients With Left Ventricular Noncompaction in Adults; A Nationwide Survey in Japan (2018)
  • Author(s): Minamisawa M, et.al.
  • Organizer: ACC 2018
  • Int'l Joint Research
• [Presentation] Role of vascular endothelial function as a predictor of recurrence of atrial fibrillation after catheter ablation. (2018)
  • Author(s): Kobayashi H, Okada A, Tabata H, Shoin W, Okano T, Oguchi Y, Shoda M, Kuwahara K
  • Organizer: Heart Rhythm Scientific Sessions 2018
  • Int'l Joint Research
• [Presentation] Recurrence of atrial fibrillation after catheter ablation is associated with fibrotic marker in coronary sinus vein and left atrium pressure. (2018)
  • Author(s): 5.Okada A, Kato K, Tabata H, Shoin W, Kobayashi H, Okano T, Oguchi Y, Shoda M, Kuwahara K.
  • Organizer: ESC2018
  • Int'l Joint Research
• [Presentation] Impact of HDL to major adverse limb event in end-stage renal disease on hemodialysis due to diabetic nephropathy from PREDICT study. (2018)
  • Author(s): Kato T, et al.
  • Organizer: Transcatheter Cardiovascular Therapeutics (TCT) 2018
  • Int'l Joint Research
• [Presentation] Superior Vena Cava Ectopy Triggered Atrial Fibrillation in the Case of Pulmonary Vein Isolation Using Cryoballoon. (2018)
  • Author(s): Yoshie K, Okada A, Tabata H, Shoin W, Kobayashi H, Okano T, Saigusa T, Ebisawa S, Motoki H, Shoda M, Kuwahara K
  • Organizer: The 11th APHRS Scientific Session(APHRS 2018).
  • Int'l Joint Research
• [Presentation] Long‐Term Serial Echocardiographic Observation In Patients With Familial Amyloid Polyneuropathy After Optimal Therapy. (2018)
  • Author(s): Koyama J, Minamisawa M, Kuwahara K.
  • Organizer: AHA2018
  • Int'l Joint Research
• [Presentation] Impact of Clinical Frailty in Patients with Peripheral Artery Disease: from I-PAD Registry. (2018)
  • Author(s): Mochidome T, Miura T, Hirabayashi M, Kashiwagi D, Yokota D, Yanagisawa T, Kato T, Hasegawa T, Machida K, Wakabayashi T, Sakai T, Senda K, Saigisa T, Ebisawa S, Okada A, Motoki H, Kuwahara K.
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Possibility of proBNP Measurement as a New Method for Evaluating the Heart Disease. (2018)
  • Author(s): 中川靖章、桑原宏一郎、錦見俊雄、木下秀之、稲住英明、森内健史、柳沢 洋、南野直人、中尾一和、木村 剛．
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Transcriptional pathways underling the development of heart failure (2018)
  • Author(s): 桑原宏一郎
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Endothelium-derived C-type natriuretic peptide regulates blood pressure through the maintenance of endothelial function (2017)
  • Author(s): Kuwahara K, Nakao K, Nishikimi T, Nakagawa Y, Kinoshita H, Tokudome T, Minamino N, Kimura T, Kangawa K, Nakao K
  • Organizer: Heart Failure 2017
  • Int'l Joint Research
• [Presentation] Endothelial dysfunction underlies blood pressure elevation in endothelium-specific C-type natriuretic peptide knockout mice. (2017)
  • Author(s): Kuwahara K, Nakao K, Nishikimi T, nakagawa Y, Tokudome T, Minamino N, Kimura T, Kangawa K, Nakao K
  • Organizer: ESC Congress 2017
  • Int'l Joint Research
• [Presentation] Alternative subcutaneous implantable cardioverter defibrillator lead placement in adult patients with complex congenital heart disease (2017)
  • Author(s): Oguchi Y, Shoda M, Kobayasshi H, Shoin W, Okano T, Takeuchi T, Okada A, Motoki H, Kuwahara K
  • Organizer: Heart Rhythm 2017
  • Int'l Joint Research
• [Presentation] 2-year natural history of lower limbs in patients with end-stage renal disease on hemodialysis due to diabetic nephropathy; from PREDICT study. (2017)
  • Author(s): Kato T, Miyashita Y, Miura T, Kanno Y, Sone H, Tokoo M, Ako S, Mizukami E, Terashima M, Yokota D, Nakagawa M, Fujimori Y, Higuchi M, Mochidome T, Sakai T, Senda K, Oguchi Y, Yamasaki S, Saigusa T, Ebisawa S, Okada A, Motoki H, Kuwahara K
  • Organizer: Transcatheter Cardiovascular Therapeutics (TCT) 2017
  • Int'l Joint Research
• [Presentation] Development and Validation of a Novel Scoring System for Predicting Chronic Outcome After Percutaneous Coronary Intervention for Coronary Chronic Total Occlusion (2017)
  • Author(s): Ebisawa S, Kosaka S, Yamane M, Muramatsu T, Okamura A, Kashima Y, Matsuno S, Sakurada M, Kijima M, Tanabe M, Habara M, Kuwahara K.
  • Organizer: AHA2017
  • Int'l Joint Research
• [Presentation] Validation of a Prognostic Risk Score for Major Bleeding Events in Patients Undergoing Percutaneous Coronary Intervention: From the SHINANO Registry (2017)
  • Author(s): Senda K, Miura T, Mochidome T, Sakai T, Minamisawa M, Kato T, Saigusa T, Ebisawa S, Motoki H, Kuwahara K.
  • Organizer: AHA2017
  • Int'l Joint Research
• [Presentation] O-linked oligosaccharaide attachment underestimates N-treminal proBNP-76(NT-proBNP) levels in heart failure(HF) and chronic renal failure (CRF) on hemodialysis (HD) (2017)
  • Author(s): Nishikimi T, Nakagawa Y, Kinoshita H, Moriuchi K, Inazumi H, Kuwahara K, Nakao K, Kimura T.
  • Organizer: ESC Congress 2017
  • Int'l Joint Research
• [Presentation] Adipocyte-derived adrenomedullin suppresses age-and obesity-related increase in blood pressure (2017)
  • Author(s): Cho Kozai, Takeya Minami, Toshio Nishikimi, Yasuaki Nakagawa, Kazuwa Nakao, Koichiro Kuwahara, Kaoru Koike, Takeshi Kimura
  • Organizer: ESC Congress 2017
  • Int'l Joint Research
• [Presentation] 脂肪由来のアドレノメデュリンは加齢および肥満に伴う血圧上昇を抑制する (2017)
  • Author(s): 趙晃済、桑原宏一郎、南丈也、錦見俊雄、南野直人、中川靖章、木下秀之、稲住英明、森内健史、寒川賢治、中尾一和、木村剛
  • Organizer: 第５４回日本臨床分子医学会学術集会
• [Presentation] A case of Macro-pro-B-Type Natriuretic Peptide (proBNP) (2017)
  • Author(s): Yasuaki Nakagawa, Toshio Nishikimi, Hiroshi Sakai, Seiko Ohno, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriuchi, Koichiro Kuwahara, Minoru Horie, Takeshi kimura
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] マクロproBNP血症の一例 (2017)
  • Author(s): 中川靖章、錦見俊雄、酒井宏、大野聖子、木下秀之、稲住英明、森内健史、柳澤洋、桑原宏一郎、堀江稔、木村剛
  • Organizer: 第21回心血管内分泌代謝学会(CVMW2017)
• [Book] 循環器疾患の最新医療 (2019)
  • Author(s): 永井良三、他
  • Total Pages: 512
  • Publisher: 先端利用技術研究所
  • ISBN: 9784925089623
• [Remarks] 信州大学医学部循環器内科
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/zouki/i-oreg/cardiovascular/