| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
|---|
| Outline of Final Research Achievements |
In the current project, we aimed to investigate the roles of newly identified lung tissue protective factors including reactive sulfur species (RSS), growth differentiation factor 11 (GDF11), and LXH9 in the pathogenesis of chronic obstructive pulmonary disease (COPD). We found that production of RSS in the COPD lungs was significantly decreased compared to those in the control subjects. In the RSS synthetase knockout mice, more airspace enlargement induced by elastase in the lungs was observed, while RSS donor significantly improved the elastase-induced emphysema in mice. Anti-aging factor, GDF11 was also decreased in the lungs and serum from the COPD patients compared with healthy subjects. The levels of serum GDF11 in the COPD patients significantly associated with the data of lung function and physical activity. Upregulation of LHX9 in type II pneumocytes was observed in the COPD patients and LHX9 was associated with cell death of type II pneumocytes.
|
