Role of newly identified lung tissue protective factors in chronic obstructive pulmonary disease

• Project/Area Number: 17H04180
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: Sugiura Hisatoshi 東北大学, 医学系研究科, 教授 (20445092)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 活性硫黄分子種 / 抗老化因子 / 転写因子 / 酸化ストレス / COPD / GDF11 / LHX9 / 新規還元分子 / 還元分子 / 成長因子

Outline of Final Research Achievements

In the current project, we aimed to investigate the roles of newly identified lung tissue protective factors including reactive sulfur species (RSS), growth differentiation factor 11 (GDF11), and LXH9 in the pathogenesis of chronic obstructive pulmonary disease (COPD). We found that production of RSS in the COPD lungs was significantly decreased compared to those in the control subjects. In the RSS synthetase knockout mice, more airspace enlargement induced by elastase in the lungs was observed, while RSS donor significantly improved the elastase-induced emphysema in mice. Anti-aging factor, GDF11 was also decreased in the lungs and serum from the COPD patients compared with healthy subjects. The levels of serum GDF11 in the COPD patients significantly associated with the data of lung function and physical activity. Upregulation of LHX9 in type II pneumocytes was observed in the COPD patients and LHX9 was associated with cell death of type II pneumocytes.

Academic Significance and Societal Importance of the Research Achievements

COPDの病態は不明な点が多く、とりわけ肺の保護因子の観点からの研究は少ない。本研究で明らかにした活性硫黄分子種は全く新規の内因性抗酸化分子でありヒト肺に存在し、COPD患者肺においてその産生量が低下しており、肺の保護作用を有することを世界で初めて明らかにした。また、COPD患者におけるGDF11の産生低下は、COPDの分子病態のみならず臨床病態とも関連することが明らかになった。LHX9は有望な転写因子でその阻害は肺気腫の進展に貢献する可能性がある。

Research Products

• [Journal Article] Decreased expression of a phagocytic receptor Siglec-1 on alveolar macrophages in chronic obstructive pulmonary disease (2020)
  • Author(s): Tanno Atsushi、Fujino Naoya、Yamada Mitsuhiro、Sugiura Hisatoshi、Hirano Taizou、Tanaka Rie、Sano Hirohito、Suzuki Satoshi、Okada Yoshinori、Ichinose Masakazu
  • Journal Title: Respiratory Research Volume: 21 Issue: 1 Pages: 30-30
  • DOI: 10.1186/s12931-020-1297-2
  • Peer Reviewed / Open Access
• [Journal Article] A case of localized tracheobronchial relapsing polychondritis with positive matrilin-1 staining. (2020)
  • Author(s): Makiguchi T, Koarai A, Inoue C, Aoyama Y, Hirano T, Ohe T, Ichikawa T, Shishikura Y, Komuro H, Tsukita Y, Tode N, Numakura T, Saito T, Sato T, Mitsuhashi Y, Tamada T, Sugiura H, Ichinose M.
  • Journal Title: BMC Rheumatol. Volume: 4 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s41927-019-0103-6
  • Peer Reviewed / Open Access
• [Journal Article] ビレーズトリTMエアロスフィア○R（ブデソニド/グリコピロニウム臭化物／ホルモテロールフマル酸塩水和物製剤） (2020)
  • Author(s): 藤野直也、杉浦久敏
  • Journal Title: 診断と治療 Volume: 108 Pages: 263-266
• [Journal Article] Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases (2019)
  • Author(s): Fujino Naoya、Brand Oliver J.、Morgan David J.、Fujimori Toshifumi、Grabiec Aleksander M.、Jagger Christopher P.、Maciewicz Rose A.、Yamada Mitsuhiro、Itakura Koji、Sugiura Hisatoshi、Ichinose Masakazu、Hussell Tracy
  • Journal Title: Journal of Experimental Medicine Volume: 216 Issue: 9 Pages: 2184-2201
  • DOI: 10.1084/jem.20171978
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nitrosative stress in patients with asthma?chronic obstructive pulmonary disease overlap (2019)
  • Author(s): Kyogoku Yorihiko、Sugiura Hisatoshi、Ichikawa Tomohiro、Numakura Tadahisa、Koarai Akira、Yamada Mitsuhiro、Fujino Naoya、Tojo Yutaka、Onodera Katsuhiro、Tanaka Rie、Sato Kei、Sano Hirohito、Yamanaka Shun、Itakura Koji、Mitsune Ayumi、Tamada Tsutomu、Akaike Takaaki、Ichinose Masakazu
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 144 Issue: 4 Pages: 972-983
  • DOI: 10.1016/j.jaci.2019.04.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increase in circulating ACE-positive endothelial microparticles during acute lung injury (2019)
  • Author(s): Takei Yusuke、Yamada Mitsuhiro、Saito Koji、Kameyama Yoshinobu、Sugiura Hisatoshi、Makiguchi Tomonori、Fujino Naoya、Koarai Akira、Toyama Hiroaki、Saito Kazutomo、Ejima Yutaka、Kawazoe Yu、Kudo Daisuke、Kushimoto Shigeki、Yamauchi Masanori、Ichinose Masakazu
  • Journal Title: European Respiratory Journal Volume: 54 Issue: 4 Pages: 1801188-1801188
  • DOI: 10.1183/13993003.01188-2018
  • Peer Reviewed / Open Access
• [Journal Article] Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas (2019)
  • Author(s): Tsukita Yoko、Fujino Naoya、Miyauchi Eisaku、Saito Ryoko、Fujishima Fumiyoshi、Itakura Koji、Kyogoku Yorihiko、Okutomo Koji、Yamada Mitsuhiro、Okazaki Tatsuma、Sugiura Hisatoshi、Inoue Akira、Okada Yoshinori、Ichinose Masakazu
  • Journal Title: Molecular Cancer Volume: 18 Issue: 1 Pages: 24-24
  • DOI: 10.1186/s12943-019-0953-y
  • Peer Reviewed / Open Access
• [Journal Article] 喘息とCOPDのオーバーラップ（Asthma and COPD overlap;ACO） (2019)
  • Author(s): 沼倉忠久、杉浦久敏
  • Journal Title: 呼吸器ジャーナル Volume: 67 Pages: 118-196
• [Journal Article] 喘息とCOPDの併存例（ACO）の診断と治療 (2019)
  • Author(s): 沼倉忠久、市川朋宏、杉浦久敏
  • Journal Title: 呼吸器内科 Volume: 35 Pages: 237-243
• [Journal Article] 気管支喘息におけるFeNO測定の意義 (2019)
  • Author(s): 杉浦久敏
  • Journal Title: 日本呼吸ケア・リハビリテーション学会誌 Volume: 28 Pages: 66-71
  • NAID: 130007668936
• [Journal Article] Pulmonary Lymphatic Perfusion Syndrome (2019)
  • Author(s): Hirano Taizou、Fujino Naoya、Takase Kei、Ota Hideki、Tanaka Rie、Saito Ryota、Suzuki Ayumi、Okutomo Koji、Sato Teruyuki、Kageyama Sakiko、Tamada Tsutomu、Sugiura Hisatoshi、Ichinose Masakazu
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 199 Issue: 4 Pages: 529-530
  • DOI: 10.1164/rccm.201806-1125im
  • Peer Reviewed / Open Access
• [Journal Article] Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis. (2018)
  • Author(s): Hirano T, Ohkouchi S, Tode N, Kobayashi M, Ono M, Satoh T, Mitsuishi Y, Watanabe A, Tabata M, Irokawa T, Ogawa H, Sugiura H, Kikuchi T, Akasaka K, Tazawa R, Inoue Y, Nakata K, Kurosawa H, Ichinose M.
  • Journal Title: ERJ open research Volume: 4 Issue: 1 Pages: 00071-2017
  • DOI: 10.1183/23120541.00071-2017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correction to: Oxidative stress enhances the expression of IL-33 in human airway epithelial cells (2018)
  • Author(s): Aizawa Hiroyuki、Koarai Akira、Shishikura Yutaka、Yanagisawa Satoru、Yamaya Mutsuo、Sugiura Hisatoshi、Numakura Tadahisa、Yamada Mitsuhiro、Ichikawa Tomohiro、Fujino Naoya、Noda Masafumi、Okada Yoshinori、Ichinose Masakazu
  • Journal Title: Respiratory Research Volume: 19 Issue: 1 Pages: 52-52
  • DOI: 10.1186/s12931-018-0817-9
  • Peer Reviewed / Open Access
• [Journal Article] Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease (2018)
  • Author(s): Rie Tanaka, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Katsuhiro Onodera, Tadahisa Numakura, Kei Sato, Yorihiko Kyogoku, Hirohito Sano, Shun Yamanaka, Tatsuma Okazaki, Tsutomu Tamada, Motohiko Miura, Tsuneyuki Takahashi, Masakazu Ichinose
  • Journal Title: Int J Chron Obstruct Pulmon Dis. Volume: 13 Pages: 1333-1342
  • DOI: 10.2147/copd.s157035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The first case of multiple pulmonary granulomas with amyloid deposition in a dental technician; a rare manifestation as an occupational lung disease (2018)
  • Author(s): Hirano Taizou、Numakura Tadahisa、Moriyama Hiroshi、Saito Ryoko、Shishikura Yutaka、Shiihara Jun、Sugiura Hisatoshi、Ichinose Masakazu
  • Journal Title: BMC Pulmonary Medicine Volume: 18 Issue: 1 Pages: 1-5
  • DOI: 10.1186/s12890-018-0654-0
  • Peer Reviewed / Open Access
• [Journal Article] Aspiration pneumonia induces muscle atrophy in the respiratory, skeletal, and swallowing systems. (2018)
  • Author(s): Riyo Komatsu, Tatsuma Okazaki, Satoru Ebihara, Makoto Kobayashi, Yoko Tsukita, Mayumi Nihei, Hisatoshi Sugiura, Kaijun Niu, Takae Ebihara, Masakazu Ichinose.
  • Journal Title: Journal of Cachexia, Sarcopenia and Muscle. Volume: 9(4) Issue: 4 Pages: 643653-643653
  • DOI: 10.1002/jcsm.12297
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease (2018)
  • Author(s): Kamata Satoshi、Fujino Naoya、Yamada Mitsuhiro、Grime Ken、Suzuki Satoshi、Ota Chiharu、Tando Yukiko、Okada Yoshinori、Sakurada Akira、Noda Masafumi、Matsuda Yasushi、Sugiura Hisatoshi、Ichinose Masakazu
  • Journal Title: Pharmacology Research & Perspectives Volume: 6 Issue: 3
  • DOI: 10.1002/prp2.405
  • Peer Reviewed / Open Access
• [Journal Article] TLR7 agonist attenuates acetylcholine-induced, Ca2+ -dependent ionic currents in swine tracheal submucosal gland cells (2018)
  • Author(s): Gamo S, Tamada T, Murakami K, Muramatsu S, Aritake H, Nara M, Kazama I, Okazaki T, Sugiura H, Ichinose M
  • Journal Title: Exp Physiol Volume: 103 Issue: 11 Pages: 1543-1559
  • DOI: 10.1113/ep087221
  • Peer Reviewed / Open Access
• [Journal Article] Coexisting COPD in elderly asthma with fixed airflow limitation: assessment by DLco %predicted and HRCT. (2017)
  • Author(s): Tamada T, Sugiura H, Takahashi T, Matsunaga K, Kimura K, Katsumata U, Ohta K, Ichinose M.
  • Journal Title: J Asthma Volume: 印刷中 Issue: 6 Pages: 1-9
  • DOI: 10.1080/02770903.2016.1247168
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer. (2017)
  • Author(s): Tode N, Kikuchi T, Sakakibara T, Hirano T, Inoue A, Ohkouchi S, Tamada T, Okazaki T, Koarai A, Sugiura H, Niihori T, Aoki Y, Nakayama K, Matsumoto K, Matsubara Y, Yamamoto M, Watanabe A, Nukiwa T, Ichinose M.
  • Journal Title: Cancer Sci Volume: 印刷中 Issue: 6 Pages: 1263-1270
  • DOI: 10.1111/cas.13233
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease. (2017)
  • Author(s): Onodera K, Sugiura H, Yamada M, Koarai A, Fujino N, Yanagisawa S, Tanaka R, Numakura T, Togo S, Sato K, Kyogoku Y, Hashimoto Y, Okazaki T, Tamada T, Kobayashi S, Yanai M, Miura M, Hoshikawa Y, Okada Y, Suzuki S, Ichinose M.
  • Journal Title: Thorax Volume: 2017 Issue: 10 Pages: 893-904
  • DOI: 10.1136/thoraxjnl-2016-209352
  • Peer Reviewed / Open Access
• [Journal Article] Invasive pulmonary mucormycosis: rare presentation with pulmonary eosinophilia. (2017)
  • Author(s): Hirano T, Yamada M, Sato K, Murakami K, Tamai T, Mitsuhashi Y, Tamada T, Sugiura H, Sato N, Saito R, Tominaga J, Watanabe A, Ichinose M.
  • Journal Title: BMC Pulm Med Volume: 17 Issue: 1 Pages: 76-76
  • DOI: 10.1186/s12890-017-0419-1
  • Peer Reviewed / Open Access
• [Journal Article] Production of reactive persulfide species in chronic obstructive pulmonary disease (2017)
  • Author(s): Numakura T, Sugiura H, Akaike T, Ida T, Fujii S, Koarai A, Yamada M, Onodera K, Hashimoto Y, Tanaka R, Sato K, Shishikura Y, Hirano T, Yanagisawa S, Fujino N, Okazaki T, Tamada T, Hoshikawa Y, Okada Y, Ichinose M
  • Journal Title: Thorax Volume: 72 Issue: 12 Pages: 1074-1083
  • DOI: 10.1136/thoraxjnl-2016-209359
  • Peer Reviewed / Open Access
• [Journal Article] Japanese guidelines for adult asthma 2017 (2017)
  • Author(s): Ichinose M, Sugiura H, Nagase H, Yamaguchi M, Inoue H, Sagara H, Tamaoki J, Tohda Y, Munakata M, Yamauchi K, Ohta K; Japanese Society of Allergology.
  • Journal Title: Allergology International Volume: 66 Issue: 2 Pages: 163-189
  • DOI: 10.1016/j.alit.2016.12.005
  • NAID: 130005628173
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] COPDのフェノタイプから見た増悪リスク (2017)
  • Author(s): 杉浦久敏
  • Journal Title: 呼吸器内科 Volume: 31 Pages: 554-561
• [Journal Article] 両下肢麻痺を来した肺真菌症の1例 (2017)
  • Author(s): 佐藤 慶、山田 充啓、平野 泰三、三橋 善哉、岡崎 達馬、玉田 勉、杉浦 久敏、一ノ瀬 正和
  • Journal Title: 日本内科学会雑誌 Volume: 106 Pages: 591-595
  • Peer Reviewed
• [Journal Article] 酸化ストレスと気道炎症 (2017)
  • Author(s): 杉浦久敏
  • Journal Title: アレルギー・免疫 Volume: 24 Pages: 450-458
• [Journal Article] 閉塞性肺疾患における気道炎症とバイオマーカー (2017)
  • Author(s): 杉浦久敏
  • Journal Title: 別冊バイオクリニカ:慢性炎症と疾患 Volume: 6 Pages: 22-26
• [Journal Article] 好酸球性肺炎の像を呈した肺接合菌症の1例 (2017)
  • Author(s): 平野 泰三、山田 充啓、村上 康司、佐藤 慶、 玉井 ときわ、 高橋 秀徳、岡崎 達馬、玉田 勉、杉浦 久敏、一ノ瀬 正和
  • Journal Title: 日本内科学会雑誌 Volume: 106 Pages: 1006-1011
  • NAID: 130006733547
  • Peer Reviewed
• [Journal Article] 酸化ストレスと喘息の重症化 (2017)
  • Author(s): 杉浦 久敏、一ノ瀬 正和
  • Journal Title: アレルギー Volume: 66 Pages: 931-935
  • NAID: 130005975420
• [Presentation] Axl Receptor Tyrosine Kinase Is Decreased in Severe Asthma and Suppresses Eosinophilic Airway Inflammation in an Allergen-Induced Asthma Model. (2019)
  • Author(s): Itakura K, Fujino N, Yamada M, Saito I, Sugiura H, Taniguchi M, Ichinose M.
  • Organizer: ATS International Conference
  • Int'l Joint Research
• [Presentation] Axl Receptor Tyrosine Kinase Up-Regurates Ligands for Programmed Cell Death 1 in Lung Adenocarcinoma. (2019)
  • Author(s): Tsukita Y, Fujino N, Miyauchi E, Itakura K, Kyogoku Y, Yamada M, Okazaki T, Sugiura H, Ichinose M.
  • Organizer: ATS International Conference
  • Int'l Joint Research
• [Presentation] Role of Reactive Persulfides/Polysulfides in Cellular Senescence of COPD. (2019)
  • Author(s): Yamanaka S,Ichikawa T,Sugiura H,Numakura T,Sano H,Yamada M, Fujino N, Tanaka R, Kyogoku Y, Akaike T, Ichinose M.
  • Organizer: ATS International Conference
  • Int'l Joint Research
• [Presentation] The Decrease of Mitochondrial Biogenesis Contributes Airway Epithelial Barrier Dysfunction in Asthma. (2019)
  • Author(s): Saito T, Ichikawa T, Numakura T , Sasaki Y, Itakura K, Yamada M, Sugiura H, Ichinose M.
  • Organizer: ATS International Conference
  • Int'l Joint Research
• [Presentation] Roles of Reactive Persulfide Species in the Lung of Elastase-Induced Emphysema Mode. (2019)
  • Author(s): Sano H, Sugiura H, Numakura T, Yamanaka S, Yamada M, Fujino N, Ichikawa T, Tanaka R, Kyogoku Y, Akaike T, Ichinose M.
  • Organizer: ATS International Conference
  • Int'l Joint Research
• [Presentation] Upregulation of Leukocyte Immunogloburin-Like Receptor B4 on Interstitial Macropharges in COPD. (2019)
  • Author(s): Mitune A, Yamada M, Fujino N, Yoshiya M, Itakura K, Sugiura H, Endo S, Takai T, Ichinose M.
  • Organizer: ATS International Conference
  • Int'l Joint Research
• [Presentation] Effects of Long-Acting Bronchodilators on Airway Mucus Quantity and Quality. (2019)
  • Author(s): Aritake H, Tamada T, Murakami K, Gamo S ,Nara M, Sugiura H, Ichinose M.
  • Organizer: ATS International Conference
  • Int'l Joint Research
• [Presentation] Reactive sulfur species are involved in cigarette smoke-induced cellular senescence. (2019)
  • Author(s): Yamanaka S, Ichikawa T, Sugiura H, Numakura T, Sano H, Yamada M, Fujino N, Tanaka R, Kyogoku Y, Akaike T, Ichinose M.
  • Organizer: ERS Annual Congress
  • Int'l Joint Research
• [Presentation] The clinical feature of malignant disease in Japanese sarcoidosis patients． (2019)
  • Author(s): Aritake H, Tamada T, Murakami K, Nara M, Gamo S, Sugiura H, Ichinose M.
  • Organizer: International conference on sarcoidosis and Interstitial Lung Disease 2019/The 39th Annual Meeting of Japan Society of Sarcoidosis and other Granulomatous Disorders.
  • Int'l Joint Research
• [Presentation] Role of anti-aging factor and reactive sulfur species in the pathogenesis of COPD (2019)
  • Author(s): Sugiura H.
  • Organizer: 128th Annual Meeting of Korean Academy of Tuberculosis and Respiratory Diseases (KATRD) meeting / KATRD International Conference 2019
  • Int'l Joint Research / Invited
• [Presentation] 敗血症患者血清中ACE陽性EMPのARDS発症に対する予測的価値． (2019)
  • Author(s): 山田充啓、武井裕介、牧口友紀、藤野直也、杉浦久敏、山内正憲、一ノ瀬正和
  • Organizer: 第59回日本呼吸器学会学術講演会
• [Presentation] Axl受容体チロシンキナーゼによる重症喘息の好酸球性気道炎症制御機構 (2019)
  • Author(s): 板倉康司、藤野直也、山田充啓、上出庸介、齋藤生朗、杉浦久敏、谷口正実、一ノ瀬正和
  • Organizer: 第59回日本呼吸器学会学術講演会
• [Presentation] IL-33を介したalternaria誘導性気道炎症におけるSecretory Leukocyte protease inhibitorの関与の検討 (2019)
  • Author(s): 平野泰三、小荒井晃、菊地利明、宍倉 裕、相澤洋之、杉浦久敏、一ノ瀬正和
  • Organizer: 第59回日本呼吸器学会学術講演会
• [Presentation] Update on pathogenesis in COPD. Role of cellular senescence on the pathogenesis of COPD. (2019)
  • Author(s): Hisatoshi Sugiura
  • Organizer: 第59回日本呼吸器学会学術講演会
  • Invited
• [Presentation] COPD病態における活性イオウ分子種の役割の検討 (2019)
  • Author(s): 山中 駿、市川朋宏、杉浦久敏、沼倉忠久、山田充啓、藤野直也、京極自彦、光根 歩、板倉康司、佐野寛仁、一ノ瀬正和
  • Organizer: 第59回日本呼吸器学会学術講演会
• [Presentation] ヒトCOPD気道におけるToll様受容体（TLR）7の発現低下と気道分泌に与える影響の検討 (2019)
  • Author(s): 蒲生俊一、玉田 勉、村上康司、有竹秀美、村松聡士、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第59回日本呼吸器学会学術講演会
• [Presentation] COPD患者肺間質マクロファージにおける抑制性受容体LILRB4の発現上昇 (2019)
  • Author(s): 光根 歩、山田充啓、藤野直也、三橋善哉、板倉康司、杉浦久敏、一ノ瀬正和
  • Organizer: 第59回日本呼吸器学会学術講演会
• [Presentation] COPDにおける新規活性イオウ分子種産生酵素の役割に関する新知見 (2019)
  • Author(s): 佐野寛仁、杉浦久敏、山田充啓、藤野直也、沼倉忠久、赤池孝章、一ノ瀬正和
  • Organizer: 第59回日本呼吸器学会学術講演会
• [Presentation] 気管支喘息における気道上皮細胞の機能障害とミトコンドリア新生の役割に関する検討 (2019)
  • Author(s): 齋藤 勉、市川朋宏、藤野直也、沼倉忠久、佐々木優作、板倉康司、山田充啓、杉浦久敏、一ノ瀬正和
  • Organizer: 第59回日本呼吸器学会学術講演会
• [Presentation] 長時間作用型気管支拡張薬が新鮮気道分泌液の特性に与える影響の検討 (2019)
  • Author(s): 有竹秀美、玉田 勉、村上康司、蒲生俊一、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第59回日本呼吸器学会学術講演会
• [Presentation] 呼気一酸化窒素測定の最新知見 (2019)
  • Author(s): 杉浦久敏
  • Organizer: 第68回日本アレルギー学会学術大会
  • Invited
• [Presentation] The decrease of mitochondrial biogenesis contributes to airway epithelial barrier dysfunction in asthma. (2019)
  • Author(s): Tomohiro Ichikawa, Tsutomu Saito, Hisatoshi Sugiura, Tadashi Numakura,Yusaku Sasaki, Naoya Fujino, Mitsuhiro Yamada, Akira Koarai, Masakazu Ichinose
  • Organizer: 第68回日本アレルギー学会学術大会
• [Presentation] Negative regulation of eosinophilic inflammation by Axl receptor tyrosine kinase in a house-dust mite-induced asthma model. (2019)
  • Author(s): Koji Itakura, Naoya Fujino, Mitsuhiro Yamada, Yousuke Kamide, Ikuo Saito, Hisatoshi Sugiura, Masami Taniguchi, Masakazu Ichinose
  • Organizer: 第68回日本アレルギー学会学術大会
• [Presentation] 喘鳴を契機に発見された小細胞肺癌術後気管内再発の1例 (2019)
  • Author(s): 小室英恵、突田容子、東出直樹、沼倉忠久、市川朋宏、山田充啓、小荒井晃、桜田 晃、杉浦久敏、一ノ瀬正和
  • Organizer: 第217回日本内科学会東北地方会
• [Presentation] 胸腔鏡下肺切除術で診断された腸型肺腺癌の1例 (2019)
  • Author(s): 宮内栄作、齊藤涼子、成田大輔、相澤洋之、村上康司、小林 誠、突田容子、東出直樹、齋藤良太、佐藤輝幸、杉浦久敏、松田安史、岡田克典、一ノ瀬正和
  • Organizer: 第58回日本肺癌学会東北支部会・第45回日本呼吸器内視鏡学会東北支部会
• [Presentation] 気管内に多発する腫瘤を認めた小細胞肺癌の1例 (2019)
  • Author(s): 鈴木 歩、宮内栄作、成田大輔、相澤洋之、東條 裕、小林 誠、村上康司、山田充啓、杉浦久敏、一ノ瀬正和
  • Organizer: 第58回日本肺癌学会東北支部会・第45回日本呼吸器内視鏡学会東北支部会
• [Presentation] 肺腺癌に対してペムブロリズマブ投与中に腸閉そくを来し免疫関連有害事象との鑑別を要した一例 (2019)
  • Author(s): 齋藤拓矢、東出直樹、小室英恵、突田容子、沼倉忠久、市川朋宏、藤野直也、小荒井晃、山田充啓、杉浦久敏、一ノ瀬正和
  • Organizer: 第109回日本呼吸器学会東北地方会、第139回日本結核病学会東北地方会
• [Presentation] 敗血症患者における血中アンギオテンシン変換酵素陽性endothelial microparticlesのARDS診断及び発症予測的価値 (2019)
  • Author(s): 山田充啓, 武井裕介, 牧口友紀, 藤野 直也, 杉浦久敏, 山内 正憲, 一ノ瀬 正和
  • Organizer: 第6回日本細胞外小胞学会学術集会
• [Presentation] Gaシンチグラフィーでnegative heart sign を認めた急性発症肺サルコイドーシスの1例 (2019)
  • Author(s): 鈴木 歩、平野泰三、玉田 勉、田中里江、藤野直也、齋藤良太、村上康司、杉浦久敏、一ノ瀬正和
  • Organizer: 第216回日本内科学会東北地方会
• [Presentation] 喘息とCOPDのオーバーラップ（ACO）における活性イオウ分子種と活性イオウ分子種産生酵素に関する検討 (2019)
  • Author(s): 京極自彦、杉浦久敏、市川朋宏、沼倉忠久、小荒井晃、山田充啓、藤野直也、田中里江、佐野寛仁、山中 駿、一ノ瀬正和
  • Organizer: 第108回日本呼吸器学会東北地方会
• [Presentation] 胆管癌治療中に発症した慢性好酸球性肺炎の一例 (2019)
  • Author(s): 京極自彦、藤野直也、村松聡士、千葉茂樹、山田充啓、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第1回日本アレルギー学会東北地方会
• [Presentation] 好酸球増多を伴う重症喘息に対してmepolizumabが奏効した一例 (2019)
  • Author(s): 大江 崇、奥友洸二、山田充啓、東出直樹、村上康司、藤野直也、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第1回日本アレルギー学会東北地方会
• [Presentation] 喘息合併COPD: 病態と治療 ACOのガイドラインにおける診断基準と治療 (2018)
  • Author(s): 杉浦 久敏
  • Organizer: 第67回日本アレルギー学会学術大会
  • Invited
• [Presentation] Update on FeNO (2018)
  • Author(s): Sugiura H
  • Organizer: APSR 2018 in Taipei
  • Int'l Joint Research / Invited
• [Presentation] Production of Reactive Persulfide Species and Their Effects in the Lungs of Patients with COPD. (2018)
  • Author(s): Numakura T, Sugiura H, Akaike T, Yamada M, Ichikawa T, Yanagisawa S, Koarai A, Ichinose M.
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Oxidative Stress Enhances the Expression of IL-33 in Airway Epithelial Cells During Virus Infection (2018)
  • Author(s): Aizawa H, Koarai A, Shishikura Y, Yanagisawa S, Yamaya M, Sugiura H, Numakura T, Yamada M, Ichikawa T, Fujino N, Noda M, Okada Y, Ichinose M
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Enhanced Nitrosative Stress in the Airways of Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap. (2018)
  • Author(s): Kyogoku Y, Sugiura H, Numakura T, Ichikawa T, Yamada M, Koarai A, Tanaka R, Ito S, Akaike T, Ichinose M
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Production of reactive persulfide species in lungs of patients with COPD and their effects on lung resident cells (2018)
  • Author(s): Numakura T, Sugiura H, Akaike T, Yamada M, Ichikawa T, Fujino N, Koarai A, Ichinose M
  • Organizer: 23rd Congress of the Asian Pacific Society of Respiratory
  • Int'l Joint Research
• [Presentation] Production of reactive nitrogen species in asthma-chronic obstructive pulmonary disease overlap. (2018)
  • Author(s): Kyogoku Y, Sugiura H, Numakura T, Ichikawa T, Yamada M, Koarai A, Tanaka R, Akaike T,
  • Organizer: 23rd Congress of the Asian Pacific Society of Respiratory
  • Int'l Joint Research
• [Presentation] COPD合併喘息（ACO）における活性窒素種と活性硫黄種に関する検討 (2018)
  • Author(s): 京極自彦、杉浦久敏、沼倉忠久、市川朋宏、山田充啓、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] ヒト気道上皮IL-33発現に対する酸化ストレスの影響 (2018)
  • Author(s): 相澤洋之、小荒井晃、宍倉 裕、柳澤 悟、山谷睦雄、杉浦久敏、沼倉忠久、山田充啓、市川朋宏、藤野直也、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] 東北メディカルメガバンク地域住民コホート調査に基づく、日本人呼気一酸化窒素濃度の分布と影響因子の解析（中間報告） (2018)
  • Author(s): 山田充啓、杉浦久敏、布施昇男、寳澤 篤、高井貴子、土屋奈歩、光根 歩、栗山進一、山本雅之、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] COPDに対する気管支拡張薬が気道被覆液の質的特性に及ぼす影響の検討 (2018)
  • Author(s): 有竹秀美、玉田 勉、村上康司、蒲生俊一、村松聡士、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] TLR7刺激による Sarco/Endoplasimic Reticulm Caicium ATPase（SERCA）作用更新についての検討 (2018)
  • Author(s): 蒲生俊一、玉田 勉、村上康司、有竹秀美、村松聡士、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] リンパ管を標的とした新規胸膜炎治療の検討 (2018)
  • Author(s): 小林 誠、岡崎達馬、突田容子、小松理世、杉浦久敏、海老原覚、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] EGFR変異遺伝子陽性肺腺癌においてAXLキナーゼは免疫抑制分子を制御する (2018)
  • Author(s): 突田容子、藤野直也、宮内栄作、井上 彰、板倉康司、山田充啓、岡崎達馬、桜田 晃、杉浦久敏、岡田克典、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] スケドスポリウム属によるステント腐生により喘息様症状を呈した1例 (2018)
  • Author(s): 大江 崇、小荒井晃、平野泰三、佐藤輝幸、市川朋宏、岡崎達馬、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第214回日本内科学会東北地方会
• [Presentation] Stevens-Johnson症候群による閉塞性肺気管支炎が疑われ、気管支鏡検査で水泡状の気道粘膜病変を認めた一例 (2018)
  • Author(s): 成田大輔、山田充啓、佐藤輝幸、市川朋宏、小林 誠、千葉茂樹、滝田克也、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第107回日本呼吸器学会東北地方会/第137回日本結核病学会東北地方会
• [Presentation] 当科における重症喘息患者に対する抗IL-5抗体治療の現状 (2018)
  • Author(s): 奥友洸二、山田充啓、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第215回日本内科学会東北地方会
• [Presentation] Role of oxidative stress in chronic obstructive pulmonary disease. (2017)
  • Author(s): Hisatoshi Sugiura
  • Organizer: KI-ToMMo joint conference Young Investigator Session.
  • Int'l Joint Research
• [Presentation] 新旧ガイドラインの比較 (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第38回日本呼吸器学会春期生涯教育講演会
  • Invited
• [Presentation] 免疫炎症細胞からみた重症呼吸器疾患の病態と治療の展望 COPD (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第57回日本呼吸器学会学術講演会
  • Invited
• [Presentation] COPDに潜む喘息 (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第57回日本呼吸器学会学術講演会
  • Invited
• [Presentation] COPDの増悪overview 増悪を来しやすいフェノタイプ (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第45回吸入療法研究会
  • Invited
• [Presentation] 新旧ガイドラインの比較 (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第38回日本呼吸器学会秋期生涯教育講演会
  • Invited
• [Presentation] 気管支喘息におけるFeNO測定の意義 (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第27回日本呼吸ケア・リハビリテーション学会学術集会
  • Invited
• [Presentation] Decreased Levels of Plasma Growth Differentiation Factor 11 Are Associated with Physical Activity, Exercise Capacity and Systemic Inflammation in COPD. (2017)
  • Author(s): Tanaka R, Sugiura H, Yamada M, Onodera K, Numakura T, Miura M, Takahashi T, Ichinose M
  • Organizer: 2017 ATS International Conference
  • Int'l Joint Research
• [Presentation] Gene Expression Profiles in Isolated Lung Endothelial Cells in Chronic Obstructive Pulmonary Disease. (2017)
  • Author(s): Tojo Y, Yamada M, Fujino N, Chiba S, Shibuya R, Koarai A, Sugiura H, Ogawa H, Ichinose M
  • Organizer: 2017 ATS International Conference
  • Int'l Joint Research
• [Presentation] Upregulation of Ca2+-ATPase by TLR7 decreases electrolyte secretion from airway submucosal gland cells. (2017)
  • Author(s): Gamo S, Tamada T, Muramatsu S, Murakami K, Nara M, Sugiura H, IchinoseM
  • Organizer: 2017 ATS International Conference
  • Int'l Joint Research
• [Presentation] Involvement of Extracellular ATP in Mucus Production During Rhinovirus Infection. (2017)
  • Author(s): Aizawa H, Koarai A, Shishikura Y, Yamaya M, Sugiura H, Watanabe M, Hashimoto Y, Numakura T, Makiguchi T, Abe K, Yamada M, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M
  • Organizer: 2017 ATS International Conference
  • Int'l Joint Research
• [Presentation] 尿中抗原陰性で喀痰PCR検査により診断されたレジオネラ肺炎の1例 (2017)
  • Author(s): 佐野寛仁、山田充啓、平野泰三、村上康司、椎原 淳、宇佐美修、玉田 勉、杉浦久敏、舘田一博、一ノ瀬正和
  • Organizer: 第210回日本内科学会東北地方会
• [Presentation] mycobacterium shinjukuense 肺感染症の1例 (2017)
  • Author(s): 山田充啓、玉井ときわ、鹿住祐子、突田容子、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第104回日本呼吸器学会東北地方会/第134回日本結核病学会東北支部学会
• [Presentation] 腫瘍崩壊症候群を自然発症した肺扁平上皮癌の1例 (2017)
  • Author(s): 板倉康司、平野泰三、宮内栄作、井上 彰、小林 誠、玉井ときわ、岡崎達馬、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第104回日本呼吸器学会東北地方会/第134回日本結核病学会東北支部学会
• [Presentation] COPDにおける老化抑制因子Growth differentiation factor11(GDF11)の関与に関する研究 (2017)
  • Author(s): 小野寺克洋、杉浦久敏、山田充啓、田中里江、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 誤嚥性肺炎はマイオカインを誘導し筋肉を委縮させる (2017)
  • Author(s): 小松理世、岡崎達馬、突田容子、小林 誠、二瓶真由美、杉浦久敏、海老原覚、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 客観的指標を用いたCOPD合併喘息の検討 (2017)
  • Author(s): 玉田 勉、杉浦久敏、高橋識至、松永和人、勝又宇一郎、木村啓二、大田 健、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] COPD患者における活性イオウ分子種（reactive sulfur species:RSS）の産生に関する検討 (2017)
  • Author(s): 沼倉忠久、杉浦久敏、赤池孝章、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] ライノウイルス感染による粘液産生誘導に対する細胞外ATPの関与の検討 (2017)
  • Author(s): 相澤洋之、小荒井晃、宍倉 裕、山谷睦雄、杉浦久敏、沼倉忠久、山田充啓、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] Axl Receptor Tyrosine Kinase Regulates Dying Cell-Triggered Proliferation of Airway Basal Cells and Is Involved Epithelial Remodeling of COPD (2017)
  • Author(s): Naoya Fujino, Toshihumi Fujimori, Aleksander M. Grabiec, Rose A.Maciewicz, Katsuhiro Onodera, Tadahisa Numakura, Mitsuhiro Yamada, Hisatoshi Sugiura, Tracy Hussell, Masakazu Ichinose
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] TLR7リガンドによる気道分泌制御作用の細胞内機序について (2017)
  • Author(s): 蒲生俊一、玉田 勉、村松聡士、村上康司、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] ライノウイルス感染によるムチン産生に対する細胞外ATPの関与の検討 (2017)
  • Author(s): 相澤洋之、小荒井晃、宍倉 裕、山谷睦雄、杉浦久敏、沼倉忠久、山田充啓、一ノ瀬正和
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] セリチニブ投与に関連した肝内胆管拡張に伴う遷延性薬剤性胆汁うっ滞を発症した肺癌の1例 (2017)
  • Author(s): 山田充啓、平野泰三、佐野寛仁、村上康司、岡崎達馬、玉田 勉、杉浦久敏、藤井博司、一ノ瀬正和
  • Organizer: 第212回日本内科学会東北地方会
• [Presentation] 可逆性の肺高血圧症を呈した強皮症によるShrinking lung syndromeの一例 (2017)
  • Author(s): 山中 駿、東條 裕、佐々木優作、千葉茂樹、宮内栄作、玉井ときわ、玉田 勉、杉浦久敏、小川浩正、一ノ瀬正和
  • Organizer: 第105回日本呼吸器学会東北地方会/第135回日本結核病学会東北地方会
• [Book] 呼吸器疾患最新の薬物療法 (2017)
  • Author(s): 山田充啓、杉浦久敏
  • Total Pages: 256
  • Publisher: 克誠堂出版