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Investigation of omics analysis and detection of biomaker to patients with airway disease progression and sleep disturbance

Research Project

Project/Area Number 17H04182
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKyoto University

Principal Investigator

Chin Kazuo  京都大学, 医学研究科, 特定教授 (90197640)

Co-Investigator(Kenkyū-buntansha) 松田 文彦  京都大学, 医学研究科, 教授 (50212220)
田原 康玄  京都大学, 医学研究科, 准教授 (00268749)
松本 久子  京都大学, 医学研究科, 准教授 (60359809)
若村 智子  京都大学, 医学研究科, 教授 (40240452)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords睡眠呼吸障害 / 睡眠時無呼吸 / 高血圧 / 糖尿病 / 肺機能低下 / メタボローム / メタボリックシンドローム / 低酸素血症 / 内膜中膜複合体 / 慢性閉塞性肺疾患 / 気管支喘息 / 睡眠障害 / オミックス / 気道疾患 / オミックス解析 / 肺機能 / バイオマーカー / 内科 / 睡眠
Outline of Final Research Achievements

A cross-sectional study evaluated 7051 community participants (Nagahama Cohort) with wrist actigraphy and nocturnal oximetry. Moderate-to-severe sleep disordered breathing (SDB). (men/premenopausal women/postmenopausal women; 23.7/1.5/9.5%, respectively) was associated with a higher risk of diabetes in premenopausal women (OR 28.1; p < 0.001) and postmenopausal women (OR 3.25; p < 0.001), but notin men. Moderate-to-severe SDB was associated with a higher risk of hypertension in men (OR 3.11; 95%CI 2.23-4.33; p < 0.001), premenopausal women (OR 3.88; 95%CI 1.42-10.6; p = 0.008), and postmenopausal women (OR 1.96; 95%CI 1.46-2.63; p < 0.001). Short sleep duration was not associated with diabetes or hypertension. The associations of obesity with diabetes or hypertension were indirectly mediated by SDB (24.0% and 21.5%, respectively), with possible sex differences emerging (men/women; 15.3/27.8% and 27.0/16.9%, respectively). Pulmonary function test and metabolome analysis were also done.

Academic Significance and Societal Importance of the Research Achievements

京都大学と滋賀県長浜市が協力の元、約1万人規模で、睡眠呼吸障害(ほとんどが睡眠時無呼吸)の肺機能低下、高血圧、糖尿病などの生活習慣病との関連と影響を検討しています。アジア最大、世界でも現状2位の規模で調査が行われています。中等度以上の睡眠呼吸障害の頻度は,男性23.7%,閉経後女性9.5%,閉経前女性1.5%と明確な性差が認められました。また、中等度以上の睡眠呼吸障害は高血圧の頻度とは男女とも有意な関連が認められましたが、糖尿病については女性のみに有意な関連が認められました。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (36 results)

All 2020 2019 2018 2017

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 11 results) Presentation (15 results) (of which Int'l Joint Research: 5 results,  Invited: 6 results) Book (5 results)

  • [Journal Article] Nocturnal hypercapnia with daytime normocapnia in patients with advanced pulmonary arterial hypertension awaiting lung transplantation2020

    • Author(s)
      Nakatsuka Y, Chen-Yoshikawa T, Kinoshita H, Aoyama A, Kubo H, Murase K, Hamada S, Takeyama H, Minami T, Takahashi N, Tanizawa K, Handa T, Hirai T, Date H, Chin K
    • Journal Title

      PLoS One

      Volume: 15 Issue: 4 Pages: e0227775-e0227775

    • DOI

      10.1371/journal.pone.0227775

    • NAID

      120006863523

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlates of autonomic nervous system function in a general population with special reference to HbA1c: The Nagahama study.2020

    • Author(s)
      Takahashi N, Takahashi Y, Tabara Y, Matsumoto T, Kawaguchi T, Kuriyama A, Ueshima K, Matsuda F, Chin K, Nakayama T; Nagahama Study Group
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 163 Pages: 108126-108126

    • DOI

      10.1016/j.diabres.2020.108126

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Randomized Controlled Trial of Telemedicine for Long-Term Sleep Apnea Continuous Positive Airway Pressure Management2020

    • Author(s)
      Murase Kimihiko、Kasai Takatoshi、Chin Kazuo
    • Journal Title

      Annals of the American Thoracic Society

      Volume: 17 Issue: 3 Pages: 329-337

    • DOI

      10.1513/annalsats.201907-494oc

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenal gland size in obstructive sleep apnea: Morphological assessment of hypothalamic pituitary adrenal axis activity.2019

    • Author(s)
      Minami T, Tachikawa R, Matsumoto T, Murase K, Tanizawa K, Inouchi M, Handa T, Oga T, Hirai T, Chin K.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 9 Pages: e0222592-e0222592

    • DOI

      10.1371/journal.pone.0222592

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lifestyle habits associated with nocturnal urination frequency: The Nagahama study2019

    • Author(s)
      Tabara Yasuharu、Matsumoto Takeshi、Murase Kimihiko、Setoh Kazuya、Kawaguchi Takahisa、Nagashima Shunsuke、Funada Satoshi、Kosugi Shinji、Hirai Toyohiro、Nakayama Takeo、Wakamura Tomoko、Chin Kazuo、Matsuda Fumihiko、the Nagahama study group
    • Journal Title

      Neurourology and Urodynamics

      Volume: 38 Issue: 8 Pages: 2359-2367

    • DOI

      10.1002/nau.24156

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between sleep disturbance and nocturnal blood pressure profiles by a linear mixed model analysis: The Nagahama study.2019

    • Author(s)
      Matsumoto T, Tabara Y, Murase K, Setoh K, Kawaguchi T, Nagashima S, Kosugi S, Nakayama T, Wakamura T, Hirai T, Matsuda F, Chin K, and the Nagahama study group.
    • Journal Title

      Sleep Med

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of sleep disturbances: sleep disordered breathing, short sleep duration and non-restorative sleep.2019

    • Author(s)
      Matsumoto T, Chin K.
    • Journal Title

      Respir Investig

      Volume: in press Issue: 3 Pages: 227-237

    • DOI

      10.1016/j.resinv.2019.01.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Day-to-Day Home Blood Pressure Variability and Orthostatic Hypotension: The Nagahama Study2018

    • Author(s)
      Tabara Yasuharu、Matsumoto Takeshi、Murase Kimihiko、Setoh Kazuya、Kawaguchi Takahisa、Nagashima Shunsuke、Kosugi Shinji、Nakayama Takeo、Wakamura Tomoko、Hirai Toyohiro、Chin Kazuo、Matsuda Fumihiko、Nagahama study group
    • Journal Title

      American Journal of Hypertension

      Volume: 31 Issue: 12 Pages: 1278-1285

    • DOI

      10.1093/ajh/hpy131

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nocturia and increase in nocturnal blood pressure2018

    • Author(s)
      Matsumoto Takeshi、Tabara Yasuharu、Murase Kimihiko、Setoh Kazuya、Kawaguchi Takahisa、Nagashima Shunsuke、Kosugi Shinji、Nakayama Takeo、Wakamura Tomoko、Hirai Toyohiro、Matsuda Fumihiko、Chin Kazuo
    • Journal Title

      Journal of Hypertension

      Volume: 36 Issue: 11 Pages: 2185-2192

    • DOI

      10.1097/hjh.0000000000001802

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of sleep characteristics and obesity on diabetes and hypertension across genders and menopausal status: the Nagahama study2018

    • Author(s)
      Matsumoto Takeshi、Murase Kimihiko、Tabara Yasuharu、et al.
    • Journal Title

      Sleep

      Volume: 41 Issue: 7

    • DOI

      10.1093/sleep/zsy071

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations of obstructive sleep apnea with truncal skeletal muscle mass and density2018

    • Author(s)
      Matsumoto Takeshi、Tanizawa Kiminobu、Tachikawa Ryo、Murase Kimihiko、Minami Takuma、Inouchi Morito、Handa Tomohiro、Oga Toru、Hirai Toyohiro、Chin Kazuo
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 6550-6557

    • DOI

      10.1038/s41598-018-24750-z

    • NAID

      120006502582

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seasonal variation in nocturnal home blood pressure fall: the Nagahama study.2018

    • Author(s)
      Tabara Y. Matsumoto T. Murase K. Nagashima S. Hirai T. Kosugi S. Nakayama T. Wakamura T. Chin K. Matsuda F. the Nagahama study group.
    • Journal Title

      Hypertens Res.

      Volume: 41 Issue: 3 Pages: 198-208

    • DOI

      10.1038/s41440-017-0003-3

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic factors in sleep-disordered breathing2018

    • Author(s)
      Tanizawa Kiminobu、Chin Kazuo
    • Journal Title

      Respiratory Investigation

      Volume: 56 Issue: 2 Pages: 111-119

    • DOI

      10.1016/j.resinv.2017.11.012

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nocturia and increase in nocturnal blood pressure: The Nagahama study.2018

    • Author(s)
      Matsumoto T, Tabara Y, Murase K, Setoh K, Kawaguchi T, Nagashima S, Kosugi S, Nakayama T, Wakamura T, Hirai T, , Matsuda F, Chin K, and the Nagahama study group.
    • Journal Title

      J Hypertens

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of sleep characteristics and obesity on diabetes and hypertension across genders and menopausal status; the Nagahama Study.2018

    • Author(s)
      Matsumoto T, Murase K, Tabara Y, Gozal D, Smith D, Minami T, Tachikawa R, Tanizawa K, Oga T, Nagashima S, Wakamura T, Komenami N, Setoh K, Kawaguchi T, Tsutsumi T, Takahashi Y, Nakayama T, Hirai T, Matsuda F, Chin K.
    • Journal Title

      Sleep

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overcoming sleep disordered breathing and ensuring sufficient good sleep time for a healthy life expectancy2017

    • Author(s)
      Chin K.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 93 Issue: 8 Pages: 609-629

    • DOI

      10.2183/pjab.93.039

    • NAID

      130006164483

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 睡眠呼吸障害の病態と治療2019

    • Author(s)
      陳和夫
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] CPAP and NIV in Japan2019

    • Author(s)
      Kazuo Chin
    • Organizer
      Taiwan Society of Pulmonary and Critical Care Medicine Meeting
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] A community-based cohort analysis for the association between sleep apnea syndrome and atherosclerosis among those without other cardiovascular risk factors ~Nagahama study~.2019

    • Author(s)
      Nakatsuka Y, Chin K, et al.
    • Organizer
      American Thoracic Society 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 在宅持続陽圧呼吸療法遠隔加算の現状と課題2019

    • Author(s)
      陳和夫
    • Organizer
      第29回 日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 肥満の進行と合併症の有無による睡眠時無呼吸の頻度:ながはまスタディ2019

    • Author(s)
      陳和夫
    • Organizer
      第40回肥満学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Overcoming sleep disordered breathing for a healthy life expectancy.2018

    • Author(s)
      Chin K.
    • Organizer
      23rd Congress of the Asian Pacific Society of Respirology.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Impact of Sleep Disordered Breathing on Diabetes Based on Presence or Absence of Family History of Diabetes; The Nagahama Study.2018

    • Author(s)
      Minami T, Matsumoto T, Tanizawa K, Murase K, Takeyama H, Oga T, Nagashima S, Wakamura T, Hirai T, Tabara Y, Matsuda F, Chin K.
    • Organizer
      American Thoracic Society 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interactions between Diabetes or Hypertension and Sleep Disordered Breathing, Objective Sleep Duration and Obesity: The Nagahama Study.2018

    • Author(s)
      Matsumoto T, Murase K, Tabara Y, Gozal D, Smith D, Minami T, Tanizawa K, Oga T, Nagashima S, Wakamura T, Hirai T, Matsuda F, Chin K.
    • Organizer
      American Thoracic Society 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 呼吸器疾患と肥満症2018

    • Author(s)
      陳 和夫
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 高血圧と糖尿病における睡眠関連因子と肥満の影響:ながはまスタディ.2018

    • Author(s)
      松本 健,村瀬 公彦,田原 康玄,Gozal David,Smith Dale,南 卓馬,谷澤 公伸,小賀 徹,長島 俊輔,若村 智子,平井 豊博,松田 文彦,陳 和夫.
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心血管疾患一次予防における陽圧呼吸療法のエビデンス2018

    • Author(s)
      陳 和夫
    • Organizer
      日本睡眠学会第43回 定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 本邦の睡眠呼吸障害の実態―ながはまコホート.2018

    • Author(s)
      松本 健,陳 和夫
    • Organizer
      第28回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高血圧と糖尿病における睡眠関連因子と肥満の影響2018

    • Author(s)
      松本健、村瀬公彦、田原康玄、David Gozal、Dale Smith、南卓馬、谷澤公伸、小賀徹、長島俊輔、若村智子、平井豊博、松田文彦、陳和夫
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Interactions Between Diabetes or Hypertension and Sleep Disordered Breathing, Objective Sleep Duration and Obesity: The Nagahama Study.2018

    • Author(s)
      Matsumoto T, Murase K, Tabara Y, Gozal D, Smith D, Minami T, Tanizawa K, Oga T, Nagashima S, Wakamura T, Hirai T, Matsuda F, Chin K.
    • Organizer
      American Thoracic Society International Conference 2018 で発表の予定
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of sleep disordered breathing on diabetes based on presence or absence of family history of diabetes; The Nagahama Study2018

    • Author(s)
      Minami T, Matsumoto T, Tanizawa K, Murase K, Takeyama H, Oga T, Nagashima S, Wakamura T, Hirai T, Tabara Y, Matsuda F, Chin K
    • Organizer
      American Thoracic Society International Conference 2018 で発表の予定
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 新臨床内科学2020

    • Author(s)
      陳和夫他
    • Total Pages
      1960
    • Publisher
      医学書院
    • ISBN
      9784260038065
    • Related Report
      2019 Annual Research Report
  • [Book] 今日の診療のためにガイドライン外来診療20202020

    • Author(s)
      陳和夫他
    • Total Pages
      726
    • Publisher
      日経BP
    • ISBN
      9784296105564
    • Related Report
      2019 Annual Research Report
  • [Book] 日常診療に活かす診療ガイドラインUP-TO-DATE 2020-20212020

    • Author(s)
      陳和夫他
    • Total Pages
      1060
    • Publisher
      メディカルレビュー社
    • ISBN
      9784779222535
    • Related Report
      2019 Annual Research Report
  • [Book] 最新呼吸器内科外科学2019

    • Author(s)
      陳和夫他
    • Total Pages
      902
    • Publisher
      メディカルレビュー社
    • ISBN
      9784779223150
    • Related Report
      2019 Annual Research Report
  • [Book] 呼吸器疾患最新の治療2019-20202019

    • Author(s)
      陳和夫他
    • Total Pages
      526
    • Publisher
      南江堂
    • ISBN
      9784524245574
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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