Investigation of omics analysis and detection of biomaker to patients with airway disease progression and sleep disturbance
| Project/Area Number |
17H04182
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
Chin Kazuo 京都大学, 医学研究科, 特定教授 (90197640)
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| Co-Investigator(Kenkyū-buntansha) |
松田 文彦 京都大学, 医学研究科, 教授 (50212220)
田原 康玄 京都大学, 医学研究科, 准教授 (00268749)
松本 久子 京都大学, 医学研究科, 准教授 (60359809)
若村 智子 京都大学, 医学研究科, 教授 (40240452)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 睡眠呼吸障害 / 睡眠時無呼吸 / 高血圧 / 糖尿病 / 肺機能低下 / メタボローム / メタボリックシンドローム / 低酸素血症 / 内膜中膜複合体 / 慢性閉塞性肺疾患 / 気管支喘息 / 睡眠障害 / オミックス / 気道疾患 / オミックス解析 / 肺機能 / バイオマーカー / 内科 / 睡眠 |
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| Outline of Final Research Achievements |
A cross-sectional study evaluated 7051 community participants (Nagahama Cohort) with wrist actigraphy and nocturnal oximetry. Moderate-to-severe sleep disordered breathing (SDB). (men/premenopausal women/postmenopausal women; 23.7/1.5/9.5%, respectively) was associated with a higher risk of diabetes in premenopausal women (OR 28.1; p < 0.001) and postmenopausal women (OR 3.25; p < 0.001), but notin men. Moderate-to-severe SDB was associated with a higher risk of hypertension in men (OR 3.11; 95%CI 2.23-4.33; p < 0.001), premenopausal women (OR 3.88; 95%CI 1.42-10.6; p = 0.008), and postmenopausal women (OR 1.96; 95%CI 1.46-2.63; p < 0.001). Short sleep duration was not associated with diabetes or hypertension. The associations of obesity with diabetes or hypertension were indirectly mediated by SDB (24.0% and 21.5%, respectively), with possible sex differences emerging (men/women; 15.3/27.8% and 27.0/16.9%, respectively). Pulmonary function test and metabolome analysis were also done.
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| Academic Significance and Societal Importance of the Research Achievements |
京都大学と滋賀県長浜市が協力の元、約1万人規模で、睡眠呼吸障害(ほとんどが睡眠時無呼吸）の肺機能低下、高血圧、糖尿病などの生活習慣病との関連と影響を検討しています。アジア最大、世界でも現状2位の規模で調査が行われています。中等度以上の睡眠呼吸障害の頻度は，男性23.7％，閉経後女性9.5％，閉経前女性1.5％と明確な性差が認められました。また、中等度以上の睡眠呼吸障害は高血圧の頻度とは男女とも有意な関連が認められましたが、糖尿病については女性のみに有意な関連が認められました。
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Nocturnal hypercapnia with daytime normocapnia in patients with advanced pulmonary arterial hypertension awaiting lung transplantation2020
Author(s)
Nakatsuka Y, Chen-Yoshikawa T, Kinoshita H, Aoyama A, Kubo H, Murase K, Hamada S, Takeyama H, Minami T, Takahashi N, Tanizawa K, Handa T, Hirai T, Date H, Chin K
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Journal Title
PLoS One
Volume: 15
Issue: 4
Pages: e0227775-e0227775
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between sleep disturbance and nocturnal blood pressure profiles by a linear mixed model analysis: The Nagahama study.2019
Author(s)
Matsumoto T, Tabara Y, Murase K, Setoh K, Kawaguchi T, Nagashima S, Kosugi S, Nakayama T, Wakamura T, Hirai T, Matsuda F, Chin K, and the Nagahama study group.
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Journal Title
Sleep Med
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Nocturia and increase in nocturnal blood pressure2018
Author(s)
Matsumoto Takeshi、Tabara Yasuharu、Murase Kimihiko、Setoh Kazuya、Kawaguchi Takahisa、Nagashima Shunsuke、Kosugi Shinji、Nakayama Takeo、Wakamura Tomoko、Hirai Toyohiro、Matsuda Fumihiko、Chin Kazuo
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Journal Title
Journal of Hypertension
Volume: 36
Issue: 11
Pages: 2185-2192
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nocturia and increase in nocturnal blood pressure: The Nagahama study.2018
Author(s)
Matsumoto T, Tabara Y, Murase K, Setoh K, Kawaguchi T, Nagashima S, Kosugi S, Nakayama T, Wakamura T, Hirai T, , Matsuda F, Chin K, and the Nagahama study group.
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Journal Title
J Hypertens
Volume: in press
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impact of sleep characteristics and obesity on diabetes and hypertension across genders and menopausal status; the Nagahama Study.2018
Author(s)
Matsumoto T, Murase K, Tabara Y, Gozal D, Smith D, Minami T, Tachikawa R, Tanizawa K, Oga T, Nagashima S, Wakamura T, Komenami N, Setoh K, Kawaguchi T, Tsutsumi T, Takahashi Y, Nakayama T, Hirai T, Matsuda F, Chin K.
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Presentation] Impact of Sleep Disordered Breathing on Diabetes Based on Presence or Absence of Family History of Diabetes; The Nagahama Study.2018
Author(s)
Minami T, Matsumoto T, Tanizawa K, Murase K, Takeyama H, Oga T, Nagashima S, Wakamura T, Hirai T, Tabara Y, Matsuda F, Chin K.
Organizer
American Thoracic Society 2018
Related Report
Int'l Joint Research
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[Presentation] Interactions between Diabetes or Hypertension and Sleep Disordered Breathing, Objective Sleep Duration and Obesity: The Nagahama Study.2018
Author(s)
Matsumoto T, Murase K, Tabara Y, Gozal D, Smith D, Minami T, Tanizawa K, Oga T, Nagashima S, Wakamura T, Hirai T, Matsuda F, Chin K.
Organizer
American Thoracic Society 2018
Related Report
Int'l Joint Research
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[Presentation] Interactions Between Diabetes or Hypertension and Sleep Disordered Breathing, Objective Sleep Duration and Obesity: The Nagahama Study.2018
Author(s)
Matsumoto T, Murase K, Tabara Y, Gozal D, Smith D, Minami T, Tanizawa K, Oga T, Nagashima S, Wakamura T, Hirai T, Matsuda F, Chin K.
Organizer
American Thoracic Society International Conference 2018 で発表の予定
Related Report
Int'l Joint Research
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[Presentation] Impact of sleep disordered breathing on diabetes based on presence or absence of family history of diabetes； The Nagahama Study2018
Author(s)
Minami T, Matsumoto T, Tanizawa K, Murase K, Takeyama H, Oga T, Nagashima S, Wakamura T, Hirai T, Tabara Y, Matsuda F, Chin K
Organizer
American Thoracic Society International Conference 2018 で発表の予定
Related Report
Int'l Joint Research
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[Book] 新臨床内科学2020
Author(s)
陳和夫他
Total Pages
1960
Publisher
医学書院
ISBN
9784260038065
Related Report
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