| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Previously we found that tertiary lymphoid tissues are formed in the aged kidney after renal injury, and cause prolonged inflammation and delayed regeneration (JCI Insight 2016). Tertiary lymphoid tissues are the structures similar to lymph nodes, and are formed in non-lymphoid tissues after chronic inflammation. Tertiary lymphoid tissues amplify the immune response through the interaction and proliferation of T cells and B cells. More recently, we have found that tertiary lymphoid tissue reflects tissue damage and inflammation (Kidney Int in press). In this study, we addressed the question, "Why does tertiary lymphoid tissue form in the aged kidney?" and identified the cells responsible for age-related tertiary lymphoid tissue formation.
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