Clinical and Pathophysiological analysis of myelin Oligodendrocyte Glycoprotein antibody-Associated Neurologic Disease

• Project/Area Number: 17H04192
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Tohoku University
• Principal Investigator: FUJIHARA KAZUO 東北大学, 医学系研究科, 大学院非常勤講師 (70280873)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000); Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: ミエリンオリゴデンドロサイト糖タンパク / 脱髄疾患 / 自己抗体 / 自己免疫性脳炎 / 多発性硬化症 / 非典型例 / 抗MOG抗体 / 視神経脊髄炎 / アストロサイトパチー

Outline of Final Research Achievements

We analyzed the clinical and pathophysiological aspects of myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease,(MOGAD).1) Clinical features of MOGAD cases were similar in Japanese and Western cases.2) We identified two types of MOG-antibody-associated cerebral cortical encephalitis (1.unilateral cerebral cortical lesion with epilepsy and 2.bilateral medial frontal cortical lesions with paraplegia). 3)Neuropathological study of MOGAD revealed that perivenous demyelination is the feature of the disease and MOG staining was preferentially lost in comparison with other myelin proteins, and the infiltrating lymphocytes were mainly CD4+. These findings indicated that MOGAD is an entity distinct from multiple sclerosis and aquaporin-4-antibody-positive neuromyelitis optica spectrum disorders.

Academic Significance and Societal Importance of the Research Achievements

ミエリンオリゴデンドロサイト糖タンパク抗体陽性神経疾患(MOGAD)は、国際的に注目されている中枢神経の炎症性脱髄疾患である。本研究は日本人MOGAD症例の特徴を明らかにした。再発性MOGADの再発予防には免疫抑制治療が必要で、多発性硬化症(MS)の疾患修飾薬は無効である。本疾患の正確な診断が適切な治療選択に重要である。また2型のMOG抗体陽性大脳皮質脳炎は、我々が世界に先駆けて報告しその後次々に同様の症例が報告されている。その病態解明が今後必要である。またperivenous demyelinationは本疾患の独立性を支持する病理所見であり、最近Brain誌に報告し注目されている。

Research Products

• [Int'l Joint Research] University of Oxford(英国)
• [Int'l Joint Research] Mayo Clinic/University of California San Fransisco/Johns Hopkins University(米国)
• [Int'l Joint Research] National Cancer Center(韓国)
• [Int'l Joint Research] Ruhr University Bochum/Charite Universitatsmedizin Berlin/Heinrich Heine University(ドイツ)
• [Int'l Joint Research] Lyon University Hospital/INSERM(フランス)
• [Int'l Joint Research]
• [Int'l Joint Research] Mayo Clinic, Rochester/Johns Hopkins University/University of Colorado(米国)
• [Int'l Joint Research] Oxford University/Walton Center, Liverpool(英国)
• [Int'l Joint Research] Charite(ドイツ)
• [Int'l Joint Research] University of Lyon(フランス)
• [Int'l Joint Research] Medical University of Vienna(オーストリア)
• [Int'l Joint Research]
• [Int'l Joint Research] University College London/University of Oxford/The Walton Center(英国)
• [Int'l Joint Research] University of Southern Denmark(デンマーク)
• [Int'l Joint Research] Pontifical Catholic University RG do Sul/University of Sao Paulo(ブラジル)
• [Int'l Joint Research] Cleveland Clinic/University of Pennsylvania/Mayo Clinic(米国)
• [Int'l Joint Research] National Cancer Center/Seoul National University(韓国)
• [Int'l Joint Research]
• [Journal Article] Repeated follow-up of AQP4-IgG titer by cell-based assay in neuromyelitis optica spectrum disorders (NMOSD) (2020)
  • Author(s): Akaishi T, Takahashi T, Nakashima I, Abe M, Ishii T, Aoki M, Fujihara K
  • Journal Title: J Neurol Sci Volume: 410 Pages: 116671-116671
  • DOI: 10.1016/j.jns.2020.116671
  • Peer Reviewed
• [Journal Article] Serum AQP4-IgG level is associated with the phenotype of the first attack in neuromyelitis optica spectrum disorders. (2020)
  • Author(s): Akaishi T, Takahashi T, Himori N, Fujihara K, Misu T, Abe M, Ishii T, Nakazawa T, Aoki M, Nakashima I.
  • Journal Title: J Neuroimmunol. Volume: 340 Pages: 577168-577168
  • DOI: 10.1016/j.jneuroim.2020.577168
  • Peer Reviewed
• [Journal Article] Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study (2020)
  • Author(s): Takai Y, Misu T, Kaneko K, Chihara N, Narikawa K, Tsuchida S, Nishida H, Komori T, Seki M, Komatsu T, Nakamagoe K, Ikeda T, Yoshida M, Takahashi T, Ono H, Nishiyama S, Kuroda H, Nakashima I, Suzuki H, Bradl M, Lassmann H, Fujihara K, Aoki M
  • Journal Title: Brain Volume: 143 Issue: 5 Pages: 1431-1446
  • DOI: 10.1093/brain/awaa102
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD (2020)
  • Author(s): Kleerekooper I, Herbert MK, Kuiperij HB, Sato DK, Fujihara K, Callegaro D, Marignier R, Saiz A, Senel M, Tumani H, de Jong BA, Trip SA, Nakashima I, Verbeek MM, Petzold A
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 91 Issue: 6 Pages: 605-611
  • DOI: 10.1136/jnnp-2019-322286
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Perivenous demyelinaton: association with anti-myelin oligodendrocyte glycoprotein antibody (2020)
  • Author(s): Misu T. Takai Y, Takahashi T, Nakashima I, Fujihara K, Aoki M
  • Journal Title: Clin Exp Neuroimmunol Volume: 11(Suppl 1) Issue: S1 Pages: 22-27
  • DOI: 10.1111/cen3.12569
  • Peer Reviewed / Open Access
• [Journal Article] MOG-IgG-associated diseas (2020)
  • Author(s): Kaneko K, Takahahi T, Misu T, Nakashima I, Fujihara K
  • Journal Title: Clin Exp Neuroimmunol Volume: 11(Suppll 1) Issue: S1 Pages: 28-33
  • DOI: 10.1111/cen3.12578
  • Peer Reviewed / Open Access
• [Journal Article] Trial of eculizumab in aquaporin-4 positive neuromyelitis optica spectrum disorder (2019)
  • Author(s): Pittock SJ, Berthele A, Fujihara K, Kim HJ, Levy M, Palace J, Nakashima I, Terzi M, Totolyan N, Viswanathan S, Wang KC, Pace A, Fujita KP, Armstrong R, Wingerchuk DM
  • Journal Title: N Engl J Med Volume: 381 Issue: 7 Pages: 614-625
  • DOI: 10.1056/nejmoa1900866
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Long-term outcome of a group of Japanese children with myelin-oligodendrocyte glycoprotein encephalomyelitis without preventive immunosuppressive therapy (2019)
  • Author(s): Hino-Fukuyo N, Haginoya K, Takahashi T, Nakashima I, Fujihara K, Takai Y, Akasaka M, Kure S
  • Journal Title: Brain Dev Volume: 41 Issue: 9 Pages: 790-795
  • DOI: 10.1016/j.braindev.2019.06.004
  • Peer Reviewed
• [Journal Article] Two Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Behçet's disease. (2019)
  • Author(s): Fujimori J, Takahashi T, Matsumoto Y, Fujihara K, Takai Y, Misu T, Nakashima I.
  • Journal Title: J Neuroimmunol Volume: 334 Pages: 577002-577002
  • DOI: 10.1016/j.jneuroim.2019.577002
  • Peer Reviewed
• [Journal Article] A randomised, placebo-controlled, double-blind trial of inebilizumab for the treatment of neuromyelitis optica spectrum disorder: results of the N-MOmentum study (2019)
  • Author(s): Cree B, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM, Fujihara K, Paul F, Cutter GR, Marignier R, Green AJ, Aktas O, Hartung HP, Lublin FD, Drappa J, Barron G, Madani S, Ratchford JN, She D, Cimbora D, Katz E
  • Journal Title: Lancet Volume: 394 Issue: 10206 Pages: 1352-1363
  • DOI: 10.1016/s0140-6736(19)31817-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Trila of satralizumab in neuromyelitis optica spectrum disorder (2019)
  • Author(s): Yamamura T, Kleiter I, Fujihara K, Palace J, Greenberg B, Zakrzewska-Pniewska B, Patti F, Tsai CP, Saiz A, Yamazaki H, Kawata Y, Wright P, De Seze J
  • Journal Title: N Engl J Med Volume: 381 Issue: 22 Pages: 2114-2124
  • DOI: 10.1056/nejmoa1901747
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regional brain volume losses and the patterns in multiple sclerosis; a cluster analysis (2019)
  • Author(s): Fujimori J, Fujihara K, Ogawa R, Baba T, Wattjes M, Nakashima I
  • Journal Title: J Neurol Volume: 267 Issue: 2 Pages: 395-405
  • DOI: 10.1007/s00415-019-09595-4
  • Peer Reviewed
• [Journal Article] NMO spectrum and MOG-antibody-related disseminated encephalomyelitis (2019)
  • Author(s): Misu T, Fujihara K
  • Journal Title: Clin Exp Neuroimmunol Volume: 10 Issue: 1 Pages: 9-17
  • DOI: 10.1111/cen3.12491
  • Peer Reviewed / Open Access
• [Journal Article] Neuromyelitis optica spectrum disorders: still evolving and broadening (2019)
  • Author(s): Fujihara K
  • Journal Title: Curr Opin Neurol Volume: 32 Issue: 3 Pages: 385-394
  • DOI: 10.1097/wco.0000000000000694
  • Peer Reviewed / Open Access
• [Journal Article] Experience from an intractable multiple sclerosis case with rebound syndrome after fingolimod cessation (2019)
  • Author(s): Kuroda H, Nishiyama S, Matsumoto Y, Misu T, Fujihara K, Aoki M
  • Journal Title: Clin Exp Neuroimmunol Volume: 10 Issue: S1 Pages: 59-62
  • DOI: 10.1111/cen3.12504
  • Peer Reviewed / Open Access
• [Journal Article] Outcome prediction models in AQP4-IgG positive neuromyelitis optica spectrum disorders: tools for clinical practice and drug trial design (2019)
  • Author(s): Palace J, Lin DY, Zeng D, Majed M, Elsone L, Hamid S, Messina S, Misu T, Sagen J, Whittam D, Takai Y, Leite MI, Weinshenker B, Cabre P, Jacob A, Nakashima I, Fujihara K, Pittock SJ
  • Journal Title: Brain Volume: 142 Issue: 5 Pages: 1310-1323
  • DOI: 10.1093/brain/awz054
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Area Postrema Syndrome: Frequency, Criteria and Severity in AQP4-IgG positive NMOSD (2018)
  • Author(s): Shosha E, Dubey D, Palace J, Nakashima I, MD, Jacob A, Fujihara K, Takahashi T, Whittam D, Leite MI, Misu T, Takai Y, Messina S, Elsone L, Majed M, Flanagan E, Gadoth A, Huebert C, Sagen J, Greenberg BM, Levy M, Banerjee A, Weinshenker B, Pittock SJ
  • Journal Title: Neurology Volume: 91 Issue: 17
  • DOI: 10.1212/wnl.0000000000006392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat (2018)
  • Author(s): Hillebrand Sophie、Schanda Kathrin、Nigritinou Magdalini、Tsymala Irina、Boehm Denise、Peschl Patrick、Takai Yoshiki、Fujihara Kazuo、Nakashima Ichiro、Misu Tatsuro、Reindl Markus、Lassmann Hans、Bradl Monika
  • Journal Title: Acta Neuropathologica Volume: 137 Issue: 3 Pages: 467-485
  • DOI: 10.1007/s00401-018-1950-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MOG encephalomyelitis: international recommendations on diagnosis and antibody testing (2018)
  • Author(s): Jarius S, Paul F, Aktas O, Asgari N, Dale RC, de Seze J, Franciotta D, Fujihara K, Jacob A, Kim HJ, Kleiter I, Kümpfel T, Levy M, Palace J, Ruprecht K, Saiz A, Trebst C, Weinshenker BG, Wildemann B
  • Journal Title: J Neuroinflammation Volume: 15 Issue: 1 Pages: 134-134
  • DOI: 10.1186/s12974-018-1144-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myein oligodendrocyte glycoprotein (MOG) antibody-associated disease: practical considerations (2018)
  • Author(s): Jurynczyk M, Jacob A, Fujihara K, Palace J
  • Journal Title: Pract Neurol Volume: - Issue: 3 Pages: 187-195
  • DOI: 10.1136/practneurol-2017-001787
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Diagnosis of Multiple Sclerosis: 2017 Revisions of the McDonald Criteria (2018)
  • Author(s): Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee, et al T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L,
  • Journal Title: Lancet Neurol Volume: 17 Issue: 2 Pages: 162-173
  • DOI: 10.1016/s1474-4422(17)30470-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A nationwide epidemiological study of neuromyelitis optica in Japan (2018)
  • Author(s): Miyamoto K, Fujihara K, Kira J, Kuriyama N, Matsui M, Tamakoshi A, Kusunoki S
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: - Issue: 6 Pages: 667-668
  • DOI: 10.1136/jnnp-2017-317321
  • Peer Reviewed
• [Journal Article] Severe aquaporin 4-IgG-positive neuromyelitis optica with disseminated herpes zoster in a pregnant woman successfully treated with intravenous immunoglobulins (2018)
  • Author(s): Matsumoto Y. Norshalena S, Tsuchiya M, Kaneko C, Kubo J, Yamamoto T, Takahashi T, Fujihara K
  • Journal Title: Mult Scler J Exp Transl Clin Volume: 4 Issue: 1
  • DOI: 10.1177/2055217318758119
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Transient Pulmonary Interstitial Lesions in Aquaporin-4-positive Neuromyelitis Optica Spectrum Disorder (2018)
  • Author(s): AsatoY, Kamitani T, Ootsuka K, Kuramochi M, Nakanishi K, Shimada T, Takahashi T, Misu T, Aoki M, FujiharaK, Kawabata Y
  • Journal Title: ingtern Med Volume: -
  • Peer Reviewed
• [Journal Article] CSF cytokine profile in MOG-IgG+neurologic disease is similar to AQP4-IgG+NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications (2018)
  • Author(s): Kaneko K, Sato DK, Nakashima I, Ogawa R, Akaishi T, Takai Y, Nishiyama S, Takahashi T, Misu T, Kuroda H, MD1), Tanaka S, Nomura K, Yuji Hashimoto Y, Callegaro D, Steinman L, Fujihara K, Aoki M
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] MOG-IgG-associated disease: an overview (2018)
  • Author(s): Fujihara K, Sato DK, Nakashima I, Takahashi T, Kaneko K, Ogawa R, Akaishi T, Matsumoto Y, Takai Y, Nishiyama S, Kuroda H, Misu T, Aoki M.
  • Journal Title: Clin Exp Neuroimmunol Volume: 9(Suppl.1) Issue: S1 Pages: 48-55
  • DOI: 10.1111/cen3.12434
  • Peer Reviewed
• [Journal Article] MOG-IgG-associated optic neuritis, encephalitis, and myelitis (MONEM): lessons learned from neuromyelitis optica spectrum disorder (2018)
  • Author(s): dos Passos GR, Oliveira LM, da Costa BK, Apostolos-Pereira SL, Callegaro D, Fujihara K, Sato DK
  • Journal Title: Front Neurol Volume: -
  • DOI: 10.3389/fneur.2018.00217
  • Peer Reviewed / Open Access
• [Journal Article] Commentary: Children with myelin oligodendrocyte glycoprotein antibodies-associated disease: relation of phenotypes to central nervous system myelin maturation (2018)
  • Author(s): Kuroda H, Fujihara K
  • Journal Title: Dev Med Child Neurol Volume: 60 Issue: 4 Pages: 339-340
  • DOI: 10.1111/dmcn.13691
  • Peer Reviewed
• [Journal Article] 2017 Japanese Guidelines for Multiple Sclerosis and Neuromyelitis Optica: achievements and challenges (2018)
  • Author(s): Fujihara K
  • Journal Title: Clin Exp Neuroimmunol Volume: 9 Issue: 1 Pages: 4-6
  • DOI: 10.1111/cen3.12450
  • Peer Reviewed / Open Access
• [Journal Article] Impact of the Great East Japan Earthquake in 2011 on MS and NMOSD: a study in Sendai, Japan (2017)
  • Author(s): Kanamori Y, Nakashima I, Takai Y, Misu T, Kuroda H, Nishiyama S, Takahashi T, Sato S, Fujimori J, Higuchi J, Itoyama Y, Aoki M, Fujihara K
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 88 Issue: 4 Pages: 362-364
  • DOI: 10.1136/jnnp-2016-313890
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MOG-antibody-positive, benign, unilateral, cerebral cortical encephalitis with epilepsy (2017)
  • Author(s): Ogawa R, Nakashima I, Takahashi T, Kaneko K, Akaishi T, Takai Y, Sato DK, Nishiyama S, Misu T, Kuroda H, Aoki M, Fujihara K
  • Journal Title: Neurol Neuroimmunol Neuroinflamm Volume: 16 Issue: 2
  • DOI: 10.1212/nxi.0000000000000322
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bilateral frontal cortex encephalitis and paraparesis in a patient with anti-MOG antibodies (2017)
  • Author(s): Fujimori J, Takai Y, Nakashima I, Sato DK, Takahashi T, Kaneko K, Nishiyama S, Watanabe M, Tanji H, Kobayashi M, Misu T, Aoki M, Fujihara K
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 印刷中 Issue: 6 Pages: 534-536
  • DOI: 10.1136/jnnp-2016-315094
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Disruption of the leptomeningeal blood barrier in neuromyelitis optica spectrum disorder (2017)
  • Author(s): Asgari N, Flanagan EP, Fujihara K, Kim HJ, Skejoe HPB, Wuerfel J, Kuroda H, Kim SH, Maillart E, Marignier R, Pittock SJ, Paul F, Weinshenker BG
  • Journal Title: Neurol Neuroimmunol Neuroiflamm Volume: 4 Issue: 4
  • DOI: 10.1212/nxi.0000000000000343
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Whole brain and grey matter volume of Japanese patients with multiple sclerosis (2017)
  • Author(s): Akaishi T, Nakashima I, Mugikura S, Aoki M, Fujihara K
  • Journal Title: J Neuroimmunol Volume: 15 Pages: 68-75
  • DOI: 10.1016/j.jneuroim.2017.03.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cognitive Impairment in Neuromyelitis Optica Spectrum Disorders: A comparison of the Wechsler Adult Intelligence Scale-III and the Wechsler Memory Scale Revised with the Rao Brief Repeatable Neuropsychological Battery (2017)
  • Author(s): Fujimori J, Nakashima I, Baba T, Meguro Y, Ogawa R, Fujihara K
  • Journal Title: eNeurologicalSci Volume: 9 Pages: 3-7
  • DOI: 10.1016/j.ensci.2017.09.001
  • Peer Reviewed / Open Access
• [Journal Article] Fingolimod-associated PML with mild IRIS in MS (2017)
  • Author(s): Nishiyama Shuhei、Misu Tatsuro、Shishido-Hara Yukiko、Nakamichi Kazuo、Saijo Masayuki、Takai Yoshiki、Takei Kentarou、Yamamoto Naoki、Kuroda Hiroshi、Saito Ryuta、Watanabe Mika、Tominaga Teiji、Nakashima Ichiro、Fujihara Kazuo、Aoki Masashi
  • Journal Title: Neurology - Neuroimmunology Neuroinflammation Volume: 5 Issue: 1
  • DOI: 10.1212/nxi.0000000000000415
  • Peer Reviewed / Open Access
• [Journal Article] Neuromyelitis optica spectrum disorders (2017)
  • Author(s): Akaishi T, Nakashima I, Sato DK, Takahashi T, Fujihara K
  • Journal Title: Neuroimaging Clin N Am Volume: 27 Issue: 2 Pages: 251-265
  • DOI: 10.1016/j.nic.2016.12.010
  • Peer Reviewed
• [Journal Article] Differential diagnosis of neuromyelitis optica spectrum disorders (2017)
  • Author(s): Kim SM, Kim SJ, Lee HJ, Kuroda H, Palace J, Fujihara K
  • Journal Title: Ther Adv Neurol Disord Volume: 10 Issue: 7 Pages: 265-289
  • DOI: 10.1177/1756285617709723
  • Peer Reviewed / Open Access
• [Journal Article] 左眼の奥が痛くて、物が見えづらいんです(左眼痛、左視力低下) (2017)
  • Author(s): 黒田 宙、藤原一男
  • Journal Title: 内科「症候から考える画像診断アトラス」 Volume: 119 Pages: 578-581
• [Presentation] There are cognitive deficits in non-brain NMOSD, NO (2020)
  • Author(s): Fujihara K
  • Organizer: European NMO Meeting 2020. Berlin (Germany)
  • Int'l Joint Research / Invited
• [Presentation] Charcot Lecture: NMO/NMOSD and anti-MOG related CNS Demyelinating Diseases. (2019)
  • Author(s): Fujihara K
  • Organizer: 54th Canadian Neurological Sciences Federation Congress, Montreal (Canada)
  • Int'l Joint Research / Invited
• [Presentation] Diagnosis of NMOSD (2019)
  • Author(s): Fujihara K
  • Organizer: Symposium of Neuroimmunology, Beijing (China)
  • Int'l Joint Research / Invited
• [Presentation] Update on NMOSD and MOG-IgG+disease (2019)
  • Author(s): Fujihara K
  • Organizer: The 5th Neuroimmunology and Neurological Infections Conference (NIC) and China Neuroimmunology Congress, Beijing (China))
  • Int'l Joint Research / Invited
• [Presentation] The differential diagnosis; NMOSD, MS, and anti-MOG (2019)
  • Author(s): Fujihara K
  • Organizer: 5th Indian Committee for Treatment and Research in Multiple Sclerosis (ICTRIMS), Kolkata (India)
  • Int'l Joint Research / Invited
• [Presentation] (Professor BS Singhal Oration): Spectrum of NMO: new developments and challenges (2019)
  • Author(s): Fujihara K
  • Organizer: 5th Indian Committee for Treatment and Research in Multiple Sclerosis (ICTRIMS), Kolkata (India),
  • Int'l Joint Research / Invited
• [Presentation] NMOSD: epidemiology update (2019)
  • Author(s): Fujihara K, hor JY
  • Organizer: 20th Brazilian Committee for Treatment and Research in Multiple Sclerosis (BCTRIMS), Sao Paulo (Brazil)
  • Int'l Joint Research / Invited
• [Presentation] Remyelination, a possible outcome: New endpoints in clinical trials for MS: remyelination, clinical improvement and more (2019)
  • Author(s): Fujihara K
  • Organizer: 20th Brazilian Committee for Treatment and Research in Multiple Sclerosis (BCTRIMS), Sao Paulo (Brazil)
  • Int'l Joint Research / Invited
• [Presentation] Neuropathological findings of MOG-antibody-associated disease (2019)
  • Author(s): Fujihara K
  • Organizer: 20th Brazilian Committee for Treatment and Research in Multiple Sclerosis (BCTRIMS), Sao Paulo (Brazil),
  • Int'l Joint Research / Invited
• [Presentation] Treatment of NMOSD (2019)
  • Author(s): Fujihara K
  • Organizer: 20th Brazilian Committee for Treatment and Research in Multiple Sclerosis (BCTRIMS), Sao Paulo (Brazil)
  • Int'l Joint Research / Invited
• [Presentation] Demyelinating Disease: MS, NMOSD and MOG-antibody-associated disease (2019)
  • Author(s): Fujihara K
  • Organizer: AIMS Neuro Imaging 2019, Tokyo (Japan),
  • Int'l Joint Research / Invited
• [Presentation] (Plenary Lecture) An introduction to CNS inflammatory demyelinating disorders (2019)
  • Author(s): Fujihara K
  • Organizer: 1st Sri Lankan Committee for Treatment and Research in Multiple Sclerosis (SLCTRIMS) Congress. Colombo (Sri Lanka),
  • Int'l Joint Research / Invited
• [Presentation] New Diagnostic Criteria for MS, a way forward (2019)
  • Author(s): Fujihara K
  • Organizer: 1st Sri Lankan Committee for Treatment and Research in Multiple Sclerosis (SLCTRIMS) Congress. Colombo (Sri Lanka),
  • Int'l Joint Research / Invited
• [Presentation] NMO spectrum disorders: from diagnosis to treatment. (2019)
  • Author(s): Fujihara K
  • Organizer: 1st Sri Lankan Commitee for Treatment and Research in Multiple Sclerosis (SLCTRIMS) Congress. Colombo (Sri Lanka)
  • Int'l Joint Research / Invited
• [Presentation] An approach to chronic inflammatory optic neuropathy (CRION) (2019)
  • Author(s): Fujihara K
  • Organizer: 1st Sri Lankan Committee for Treatment and Research in Multiple Sclerosis (SLCTRIMS) Congress. Colombo (Sri Lanka),
  • Int'l Joint Research / Invited
• [Presentation] MOG-antibody-associated disease (2019)
  • Author(s): Fujihara K
  • Organizer: Tiantian Neuroinfection & Neuroimmunology Forum (TNNF) 2019 Chinese Medical Network for Neuroinflammation (CMNN) 2019. Beijing (China),
  • Int'l Joint Research / Invited
• [Presentation] (Main Topic 5A: MS AND DEMYELINATING DISORDERS) IS AN INTERNATIONAL CONSENSUS POSSIBLE?. (2019)
  • Author(s): Fujihara K
  • Organizer: World Congress of Neurology 2019. Dubai (UAE)
  • Int'l Joint Research / Invited
• [Presentation] NMO and MOG-SD (2019)
  • Author(s): Fujihara K
  • Organizer: Istanbul MS Days 2019, Istanbul (Turkey)
  • Int'l Joint Research / Invited
• [Presentation] Biomarkers and Diagnosis of MS and NMOSD L-20) Lumpers and splitters in NMOSD: Does it matter? (2019)
  • Author(s): Fujihara K
  • Organizer: 12th Pan-Asian Committee for Treatment and Research in Multiple Sclerosisi (PACTRIMS), Singapore,
  • Int'l Joint Research / Invited
• [Presentation] Role of Pathogenic Antibodies. The Example of MOG Antibody Associated IDD) From Immunology to Treatment (2019)
  • Author(s): Fujihara K
  • Organizer: 27th Annual Meeting of the European Charcot Foundation. Baveno (Italy)
  • Int'l Joint Research / Invited
• [Presentation] (Closing Lecture) MOG-antibody-associated disease. From immunology to treatment (2019)
  • Author(s): Fujihara K
  • Organizer: Japanese Multiple Sclerosis Society International symposium. Tokyo (Japan),
  • Int'l Joint Research / Invited
• [Presentation] Neuromyelitis Optica, Clinical Aspects of Therapy (2019)
  • Author(s): Fujihara K
  • Organizer: 5th Middle-East and North African Committee for Treatment and Research in Multiple Sclerosis (MENACTRIMS), Decmber 6, Dubai (UAE)
  • Int'l Joint Research / Invited
• [Presentation] The clinical spectrum and prognosis of MOG-Ab associated disease, Atypical preesntation (2019)
  • Author(s): Fujihara K
  • Organizer: European Committee for Treatment and Research in Multiple Sclerosisi (ECTRIMS) 7th Focused Workshop
  • Int'l Joint Research / Invited
• [Presentation] World atlas of NMO. NMO state of the union, building on success: the next decade of NMO (2018)
  • Author(s): Fujihara K.
  • Organizer: 10th Annual International NMO Roundtable Conference
  • Int'l Joint Research / Invited
• [Presentation] Was anything left aside in the 2017 McDonald criteria for the diagnosis of MS? (2018)
  • Author(s): Fujihara K
  • Organizer: 19th Annual Congress of Brazilian Committee for Treatment and Research in multiple Sclerosis (BCTRIMS)
  • Int'l Joint Research / Invited
• [Presentation] Predominantly spinal MS versus seronegative NMOSD: diagnostic issues (2018)
  • Author(s): Fujihara K
  • Organizer: 19th Annual Congress of Brazilian Committee for Treatment and Research in multiple Sclerosis (BCTRIMS)
  • Int'l Joint Research / Invited
• [Presentation] Differenial diagnosis of demyelinating diseases) NMO Spectrum Disorders: an Update (2018)
  • Author(s): Fujihara k
  • Organizer: 3rd Russian Committee for Treatment and Research in Multiple Sclerosis (RUCTRIMS)
  • Int'l Joint Research / Invited
• [Presentation] Learning from NMOSD Patients) Toward approved NMOSD therapeutics: clinical perspectives (2018)
  • Author(s): Fujihara K
  • Organizer: Guthy-Jackson Charitable Foundation NMO Symposium
  • Int'l Joint Research / Invited
• [Presentation] NMOSD Current concept and clinical management: MOG-antibody disease update and differentiation from MS and AQP4-antibody positive disease (2018)
  • Author(s): Fujihara K
  • Organizer: 34th Congress of European Committee on Treatment and Research in Multiple Sclerosis (ECTRIMS)
  • Int'l Joint Research / Invited
• [Presentation] The Approach to the Management of Indeterminate MS/NMOSD (2018)
  • Author(s): Fujihara K
  • Organizer: 11th Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTIRMS)
  • Int'l Joint Research / Invited
• [Presentation] Demyelinating Disorders, Diagnostic approach in CNS Demyelinating Diseases (2018)
  • Author(s): Fujihara K
  • Organizer: 16th Asian Oceanian Congress of Neurology
  • Int'l Joint Research / Invited
• [Presentation] MOG-ab-positive patients should be under the umbrella of AQP4-ab-negative NMOSD: For. (2018)
  • Author(s): Fujihara K
  • Organizer: 16th Asian Oceanian Congress of Neurology
  • Int'l Joint Research / Invited
• [Presentation] Long term observation of diseases at the border of MS and of pediatric MS: NMO Spectrum Disorders (2018)
  • Author(s): Fujihara K
  • Organizer: 26th Annual Meeting of European Charcot Foundation
  • Int'l Joint Research / Invited
• [Presentation] Overview of clinical signs and symptoms of spinal cord pathology in MS and NMOSD: gait, pain, bladder/bowel, sexual function (2017)
  • Author(s): Fujihara K
  • Organizer: International Conference on Spinal Cord Involvement and imaging in MS and NMOSD
  • Int'l Joint Research / Invited
• [Presentation] Evolution of disgnostic criteria and its impact on disease management. in Session 1: advaincing the diagnosis and management in MS (2017)
  • Author(s): Fujihara K
  • Organizer: UCB APAC MS Summit 2017
  • Int'l Joint Research / Invited
• [Presentation] NMOSD: an update (2017)
  • Author(s): Fujihara K
  • Organizer: The 3rd Indian Committee for Treatment and Resarch in Multiple Sclerosis (ICTRIMS)
  • Int'l Joint Research / Invited
• [Presentation] MOG-IgG-associated neurologic disease (2017)
  • Author(s): Fujihara K
  • Organizer: The 3rd Indian Committee for Treatment and Resarch in Multiple Sclerosis (ICTRIMS)
  • Int'l Joint Research / Invited
• [Presentation] Intermediate forms between MS and seronegative NMOSD, How to solve this diagnostic puzzle ? (2017)
  • Author(s): Fujihara K
  • Organizer: The 18th Meeting of Brazilian Committee for Treatment and Resarch in Multiple Sclerosis (BCTRIMS)
  • Int'l Joint Research / Invited
• [Presentation] Is NMO a disease or syndrome with different etiologies ? (2017)
  • Author(s): Fujihara K
  • Organizer: The 18th Meeting of Brazilian Committee for Treatment and Resarch in Multiple Sclerosis (BCTRIMS)
  • Int'l Joint Research / Invited
• [Presentation] Diagnostic criteria of MS: new insights and challenges (2017)
  • Author(s): Fujihara K
  • Organizer: The 18th Meeting of Brazilian Committee for Treatment and Resarch in Multiple Sclerosis (BCTRIMS)
  • Int'l Joint Research / Invited
• [Presentation] Pathogenesis of NMOSD (2017)
  • Author(s): Fujihara K
  • Organizer: The 23rd World Congress of Neurology
  • Int'l Joint Research / Invited
• [Presentation] Rheurmatology and NMO overlap (2017)
  • Author(s): Fujihara K
  • Organizer: The 23rd World Congress of Neurology
  • Int'l Joint Research / Invited
• [Presentation] Update on pathogenesis of NMOSD (2017)
  • Author(s): Fujihara K
  • Organizer: The 7th Joint ECTRIMS-ACTRIMS Meeting (MSParis 2017)
  • Int'l Joint Research / Invited
• [Presentation] Symptomatic treatment in MS, NMOSD (2017)
  • Author(s): Fujihara K
  • Organizer: European Charcot Foundation Symposium in The 10th Pan-Asian Committee for Teratment and Resarch in Multiple Sclerosis (PACTRIMS),
  • Int'l Joint Research / Invited
• [Presentation] Update on pathogenesis of NMOSD (2017)
  • Author(s): Fujihara K
  • Organizer: Istanbul MS Days 2017
  • Int'l Joint Research / Invited
• [Book] Pocket Drugs 2020 (2020)
  • Author(s): 藤原一男
  • Total Pages: 6
  • Publisher: 医学書院
  • ISBN: 9784260039161
• [Book] Pocket Drugs 2019 (2019)
  • Author(s): 藤原一男
  • Total Pages: 6
  • Publisher: 医学書院
  • ISBN: 9784260036146
• [Book] 今日の治療指針 2018年版 私はこう治療している (2018)
  • Author(s): 藤原一男
  • Total Pages: 2
  • Publisher: 医学書院
• [Book] Pocket Drugs 2018 (2018)
  • Author(s): 藤原一男
  • Total Pages: 6
  • Publisher: 医学書院
• [Book] 多発性硬化症・視神経脊髄炎診療ガイドライン 2017 (2017)
  • Author(s): 松井 真、新野正明、岡本智子、越智博文、河内 泉、近藤誉之、清水優子、野村恭一、深澤俊行、藤原一男、真崎勝久、宮本勝一
  • Total Pages: 18
  • Publisher: 医学書院
• [Book] 神経救急・集中治療ハンドブック (2017)
  • Author(s): 高橋利幸、藤原一男
  • Total Pages: 6
  • Publisher: 医学書院