Perturbation of redox balance in pathophysiology of diabetes

• Project/Area Number: 17H04199
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kanazawa University
• Principal Investigator: Takamura Toshinari 金沢大学, 医学系, 教授 (00324111)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 2型糖尿病 / ヘパトカイン / 酸化ストレス / 還元ストレス / 活性酸素種 / 熱産生 / 褐色脂肪組織 / 骨粗鬆症 / 酸化還元ストレス / セレノプロテインP / 酸化還元 / 褐色脂肪細胞 / 骨 / 酸化・還元ストレス / カテコラミン / 糖尿病 / ストレス / 生体分子 / シグナル伝達 / 発生・分化

Outline of Final Research Achievements

Various antioxidant drugs have been clinically applied to reduce oxidative stress, but none have achieved sufficient therapeutic efficacy. Selenoprotein P (SeP) is a hepatokine, a bioactive molecule derived from the liver, which plays roles in the pathogenesis of type 2 diabetes. In the present study, we show that SeP is an endogenous factor that induces signal transduction via eliminating physiological reactive oxygen species. Such SeP-mediated reductive stress caused diabetic pathology in the brown adipose tissue and bone. These findings suggest that SeP is a potential novel therapeutic target against diabetic complications.

Academic Significance and Societal Importance of the Research Achievements

本研究はSePが還元ストレスを介して、臓器におけるシグナル伝達抵抗性をもたらすことを明らかにした。よって、糖尿病、肥満症、動脈硬化症をはじめとする生活習慣病に対して、新しい概念に基づく治療・診断技術開発、そして治療薬への道が拓ける。さらに学術的にも、これまで酸化ストレスによって説明されてきたインスリン抵抗性や老化のメカニズムに、「制御された生理的ROSの機能」の視点から再構築を迫ることになる。

Research Products

• [Int'l Joint Research] Loughborough University(英国)
• [Journal Article] Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat (2022)
  • Author(s): Oo Swe Mar、Oo Hein Ko、Takayama Hiroaki、Ishii Kiyo-aki、Takeshita Yumie、Goto Hisanori、Nakano Yujiro、Kohno Susumu、Takahashi Chiaki、Nakamura Hiroyuki、Saito Yoshiro、Matsushita Mami、Okamatsu-Ogura Yuko、Saito Masayuki、Takamura Toshinari
  • Journal Title: Cell Reports Volume: 38 Issue: 13 Pages: 110566-110566
  • DOI: 10.1016/j.celrep.2022.110566
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of selenoprotein P expression in the function of pancreatic β cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation (2022)
  • Author(s): Kitabayashi Nanako、Nakao Shohei、Mita Yuichiro、Arisawa Kotoko、Hoshi Takayuki、Toyama Takashi、Ishii Kiyo-aki、Takamura Toshinari、Noguchi Noriko、Saito Yoshiro
  • Journal Title: Free Radical Biology and Medicine Volume: 183 Pages: 89-103
  • DOI: 10.1016/j.freeradbiomed.2022.03.009
  • Peer Reviewed / Open Access
• [Journal Article] Lauric acid impairs insulin-induced Akt phosphorylation by upregulating SELENOP expression via HNF4α induction (2022)
  • Author(s): Kamoshita Kyoko、Tsugane Hirohiko、Ishii Kiyo-aki、Takayama Hiroaki、Yao Xingyu、Abuduwaili Halimulati、Tanida Ryota、Taniguchi Yasumasa、Oo Hein Ko、Gafiyatullina Guzel、Kaneko Shuichi、Matsugo Seiichi、Takamura Toshinari
  • Journal Title: American Journal of Physiology-Endocrinology and Metabolism Volume: in press Issue: 6 Pages: E556-E568
  • DOI: 10.1152/ajpendo.00163.2021
  • Peer Reviewed
• [Journal Article] Identification of ENPP1 Haploinsufficiency in Patients With Diffuse Idiopathic Skeletal Hyperostosis and Early‐Onset Osteoporosis (2022)
  • Author(s): Kato Hajime、Ansh Anenya J、Lester Ethan R、Kinoshita Yuka、Hidaka Naoko、Hoshino Yoshitomo、Koga Minae、Taniguchi Yuki、Uchida Taisuke、Yamaguchi Hideki、Niida Yo、Nakazato Masamitsu、Nangaku Masaomi、Makita Noriko、Takamura Toshinari、Saito Taku、Braddock Demetrios T、Ito Nobuaki
  • Journal Title: Journal of Bone and Mineral Research Volume: - Issue: 6 Pages: 1125-1135
  • DOI: 10.1002/jbmr.4550
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Forkhead box protein O1 (FoxO1) knockdown accelerates the eicosapentaenoic acid (EPA)-mediated <i>Selenop</i> downregulation independently of sterol regulatory element-binding protein-1c (SREBP-1c) in H4IIEC3 hepatocytes (2022)
  • Author(s): K Kamoshita, N Tajima-Shirasaki, KA Ishii, T Shirasaki, H Takayama, H Abuduwaili, T Abuduyimiti, HK Oo, X Yao, Q Li, CM Galicia-Medina, S Kaneko, T Takamura.
  • Journal Title: Endocrine Journal Volume: 69 Issue: 8 Pages: 907-918
  • DOI: 10.1507/endocrj.EJ21-0392
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GHS-R1a deficiency mitigates lipopolysaccharide-induced lung injury in mice via the downregulation of macrophage activity (2022)
  • Author(s): Tanida Ryota、Tsubouchi Hironobu、Yanagi Shigehisa、Saito Yusuke、Toshinai Koji、Miyazaki Taiga、Takamura Toshinari、Nakazato Masamitsu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 589 Pages: 260-266
  • DOI: 10.1016/j.bbrc.2021.12.044
  • Peer Reviewed
• [Journal Article] Insulin-glucagon‐like peptide‐1 receptor agonist relay and glucagon‐like peptide‐1 receptor agonist first regimens in individuals with type2 diabetes: A randomized, open‐label trial study (2022)
  • Author(s): Takeshita Yumie、Takamura Toshinari、et al.
  • Journal Title: Journal of Diabetes Investigation Volume: in press Issue: 6 Pages: 965-974
  • DOI: 10.1111/jdi.13749
  • Peer Reviewed
• [Journal Article] Effects of eicosapentaenoic acid on serum levels of selenoprotein P and organ‐specific insulin sensitivity in humans with dyslipidemia and type 2 diabetes (2021)
  • Author(s): Takeshita Yumie、Teramura Chisato、Kamoshita Kyoko、Takayama Hiroaki、Nakagawa Hiromi、Enyama Yasufumi、Ishii Kiyo‐Aki、Tanaka Takeo、Goto Hisanori、Nakano Yujiro、Osada Sachie、Tanaka Yoshiaki、Tokuyama Kumpei、Takamura Toshinari
  • Journal Title: Journal of Diabetes Investigation Volume: 13 Issue: 3 Pages: 532-542
  • DOI: 10.1111/jdi.13699
  • Peer Reviewed / Open Access
• [Journal Article] Distinct effects of carbohydrate ingestion timing on glucose fluctuation and energy metabolism in patients with type 2 diabetes: a randomized controlled study (2021)
  • Author(s): Enyama Yasufumi、Takeshita Yumie、Tanaka Takeo、Sako Saori、Kanamori Takehiro、Takamura Toshinari
  • Journal Title: Endocrine Journal Volume: 68 Issue: 10 Pages: 1225-1236
  • DOI: 10.1507/endocrj.EJ20-0623
  • NAID: 130008111220
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] A mosaic mutation of phosphate-regulating gene with homologies to endopeptidases on the X chromosome (<i>PHEX</i>) in X-linked hypophosphatemic rickets with mild bone phenotypes (2021)
  • Author(s): Asano Shoko、Sako Saori、Funasaki Yuka、Takeshita Yumie、Niida Yo、Takamura Toshinari
  • Journal Title: Endocrine Journal Volume: 68 Issue: 9 Pages: 1135-1141
  • DOI: 10.1507/endocrj.EJ20-0809
  • NAID: 130008093159
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Eight-year longitudinal study of whole blood gene expression profiles in individuals undergoing long-term medical follow-up (2021)
  • Author(s): Sakai Yoshio、Nasti Alessandro、Takeshita Yumie、Okumura Miki、Kitajima Shinji、Honda Masao、Wada Takashi、Nakamura Seiji、Takamura Toshinari、Tamura Takuro、Matsubara Kenichi、Kaneko Shuichi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 16564-16564
  • DOI: 10.1038/s41598-021-96078-0
  • Peer Reviewed / Open Access
• [Journal Article] Decline in serum albumin concentration is a predictor of serious events in nonalcoholic fatty liver disease (2021)
  • Author(s): Kawaguchi Kazunori、Sakai Yoshio、Terashima Takeshi、Shimode Tetsuhiro、Seki Akihiro、Orita Noriaki、Takeshita Yumie、Shimakami Tetsuro、Takatori Hajime、Arai Kuniaki、Kitamura Kazuya、Yamashita Taro、Yamashita Tatsuya、Takamura Masayuki、Mizukoshi Eishiro、Takamura Toshinari、Honda Masao、Wada Takashi、Kaneko Shuichi
  • Journal Title: Medicine Volume: 100 Issue: 31 Pages: e26835-e26835
  • DOI: 10.1097/md.0000000000026835
  • Peer Reviewed / Open Access
• [Journal Article] LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH (2021)
  • Author(s): Takata Noboru、Ishii Kiyo-aki、Takayama Hiroaki、Nagashimada Mayumi、Kamoshita Kyoko、Tanaka Takeo、Kikuchi Akihiro、Takeshita Yumie、Matsumoto Yukako、Ota Tsuguhito、Yamamoto Yasuhiko、Yamagoe Satoshi、Seki Akihiro、Sakai Yoshio、Kaneko Shuichi、Takamura Toshinari
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 555-555
  • DOI: 10.1038/s41598-020-80689-0
  • Peer Reviewed / Open Access
• [Journal Article] Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans (2021)
  • Author(s): Isobe Yuki、Asakura Hiroki、Tsujiguchi Hiromasa、Kannon Takayuki、Takayama Hiroaki、Takeshita Yumie、Ishii Kiyo-aki、Kanamori Takehiro、Hara Akinori、Yamashita Tatsuya、Tajima Atsushi、Kaneko Shuichi、Nakamura Hiroyuki、Takamura Toshinari
  • Journal Title: Frontiers in Nutrition Volume: 8 Pages: 633703-633703
  • DOI: 10.3389/fnut.2021.633703
  • Peer Reviewed / Open Access
• [Journal Article] Acute Hyperenergetic, High-Fat Feeding Increases Circulating FGF21, LECT2, and Fetuin-A in Healthy Men (2020)
  • Author(s): Willis Scott A、Sargeant Jack A、Yates Thomas、Takamura Toshinari、Takayama Hiroaki、Gupta Vinay、Brittain Emily、Crawford Joe、Parry Si?n A、Thackray Alice E、Varela-Mato Veronica、Stensel David J、Woods Rachel M、Hulston Carl J、Aithal Guruprasad P、King James A
  • Journal Title: The Journal of Nutrition Volume: 150 Issue: 5 Pages: 1076-1085
  • DOI: 10.1093/jn/nxz333
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hepatokine Selenoprotein P-Mediated Reductive Stress Causes Resistance to Intracellular Signal Transduction (2020)
  • Author(s): Takamura Toshinari
  • Journal Title: Antioxidants & Redox Signaling Volume: 33 Issue: 7 Pages: 517-524
  • DOI: 10.1089/ars.2020.8087
  • Peer Reviewed / Open Access
• [Journal Article] Secondary analyses to assess the profound effects of empagliflozin on endothelial function in patients with type?2 diabetes and established cardiovascular diseases: The placebo‐controlled double‐blind randomized effect of empagliflozin on endothelial function in cardiovascular high risk diabetes mellitus: Multi‐center placebo‐controlled double‐blind randomized trial (2020)
  • Author(s): Tanaka Atsushi、Shimabukuro Michio、Machii Noritaka、Teragawa Hiroki、Okada Yosuke、Shima Kosuke R.、Takamura Toshinari、Taguchi Isao、Hisauchi Itaru、Toyoda Shigeru、Matsuzawa Yasushi、Tomiyama Hirofumi、Yamaoka‐Tojo Minako、Ueda Shinichiro、Higashi Yukihito、Node Koichi
  • Journal Title: Journal of Diabetes Investigation Volume: 11 Issue: 6 Pages: 1551-1563
  • DOI: 10.1111/jdi.13289
  • Peer Reviewed / Open Access
• [Journal Article] Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice (2020)
  • Author(s): Kikuchi Akihiro、Takayama Hiroaki、Tsugane Hirohiko、Shiba Kazuhiro、Chikamoto Keita、Yamamoto Tatsuya、Matsugo Seiichi、Ishii Kiyo-aki、Misu Hirofumi、Takamura Toshinari
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 13260-13260
  • DOI: 10.1038/s41598-020-70192-x
  • NAID: 120007185663
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between handgrip strength and albuminuria in community-dwelling elderly Japanese subjects: the Shika Study (2020)
  • Author(s): Hara Akinori、Tsujiguchi Hiromasa、Suzuki Keita、Tao Yuichi、Nakamura Haruki、Kasahara Tomoko、Nguyen Thao Thi Thu、Miyagi Sakae、Shimizu Yukari、Kannon Takayuki、Tajima Atsushi、Wada Takashi、Takamura Toshinari、Nakamura Hiroyuki
  • Journal Title: Biomarkers Volume: 25 Issue: 7 Pages: 587-593
  • DOI: 10.1080/1354750x.2020.1819418
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolic and sympathovagal effects of bolus insulin glulisine versus basal insulin glargine therapy in people with type?2 diabetes: A randomized controlled study (2020)
  • Author(s): Takeshita Yumie、Tanaka Takeo、Wakakuri Hitomi、Kita Yuki、Kanamori Takehiro、Takamura Toshinari
  • Journal Title: Journal of Diabetes Investigation Volume: in press Issue: 7 Pages: 1193-1201
  • DOI: 10.1111/jdi.13471
  • Peer Reviewed / Open Access
• [Journal Article] Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans (2019)
  • Author(s): Mohri K, Misu H, Takayama H, Ishii KA, Kikuchi A, Lan F, Enyama Y, Takeshita Y, Saito Y, Kaneko S,Takamura T.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 42 Issue: 3 Pages: 373-378
  • DOI: 10.1248/bpb.b18-00549
  • NAID: 130007607371
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2019-03-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity. (2019)
  • Author(s): Murai K, Honda M, Shirasaki T, Shimakami T, Omura H, Misu H, Kita Y, Takeshita Y, Ishii KA, Takamura T, Urabe T, Shimizu R, Okada H, Yamashita T, Sakai Y, Kaneko S.
  • Journal Title: Cell Host Microbe Volume: 10;25(4) Issue: 4 Pages: 588-601
  • DOI: 10.1016/j.chom.2019.02.015
  • Peer Reviewed / Open Access
• [Journal Article] p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes (2019)
  • Author(s): Igawa Hirobumi、Kikuchi Akihiro、Misu Hirofumi、Ishii Kiyo-aki、Kaneko Shuichi、Takamura Toshinari
  • Journal Title: Journal of Diabetes Investigation Volume: 10 Issue: 1 Pages: 32-42
  • DOI: 10.1111/jdi.12866
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits (2018)
  • Author(s): Saito Yoshiro、Misu Hirofumi、Takayama Hiroaki、Takashima Shin-ichiro、Usui Soichiro、Takamura Masayuki、Kaneko Shuichi、Takamura Toshinari、Noguchi Noriko
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 41 Issue: 5 Pages: 828-832
  • DOI: 10.1248/bpb.b18-00046
  • NAID: 130006730702
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2018-05-01
  • Peer Reviewed / Open Access
• [Journal Article] Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice. (2018)
  • Author(s): Chikata A, Kato T, Usuda K, Fujita S, Maruyama M, Nagata Y, Sakagami S, Kanamori N, Yaegashi T, Saeki T, Kusayama T, Usui S, Furusho H, Kaneko S, Takamura M.
  • Journal Title: Int J Mol Sci. Volume: 19 Issue: 3 Pages: 878-878
  • DOI: 10.3390/ijms19030878
  • Peer Reviewed / Open Access
• [Journal Article] Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population. (2018)
  • Author(s): Oo SM, Misu H, Saito Y, Tanaka M, Kato S, Kita Y, Takayama H, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Matsuyama N, Kaneko S, Takamura T.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 16727-16727
  • DOI: 10.1038/s41598-018-35067-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibin betaE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples (2018)
  • Author(s): M. Sugiyama, A. Kikuchi, H. Misu, H. Igawa, M. Ashihara, Y. Kushima, K. Honda, Y. Suzuki, Y. Kawabe, S. Kaneko and T. Takamura
  • Journal Title: PLoS One Volume: 13 Issue: 3 Pages: e0194798-e0194798
  • DOI: 10.1371/journal.pone.0194798
  • Peer Reviewed / Open Access
• [Journal Article] Ursodeoxycholic acid potentiates dipeptidyl peptidase-4 inhibitor sitagliptin by enhancing glucagon-like peptide-1 secretion in patients with type 2 diabetes and chronic liver disease: a pilot randomized controlled and add-on study (2018)
  • Author(s): K. R. Shima, T. Ota, K. I. Kato, Y. Takeshita, H. Misu, S. Kaneko and T. Takamura
  • Journal Title: BMJ Open Diabetes Res Care Volume: 6 Issue: 1 Pages: e000469-e000469
  • DOI: 10.1136/bmjdrc-2017-000469
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men (2017)
  • Author(s): Sargeant Jack A.、Aithal Guruprasad P.、Takamura Toshinari、Misu Hirofumi、Takayama Hiroaki、Douglas Jessica A.、Turner Mark C.、Stensel David J.、Nimmo Myra A.、Webb David R.、Yates Thomas、King James A.
  • Journal Title: Appl Physiol Nutr Metab Volume: 3 Issue: 5 Pages: 1-9
  • DOI: 10.1139/apnm-2017-0639
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle. (2017)
  • Author(s): H Misu, H Takayama, Y Saito, Y Mita, A Kikuchi, K Ishii, K Chikamoto, T Kanamori, N Tajima, F Lan, Y Takeshita, M Honda, M Tanaka, S Kato, N Matsuyama, Y Yoshioka, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, S Kaneko, T Takamura.
  • Journal Title: Nature Med Volume: 23 Issue: 4 Pages: 508-516
  • DOI: 10.1038/nm.4295
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes. (2017)
  • Author(s): Tajima-Shirasaki N, Ishii KA, Takayama H, Shirasaki T, Iwama H, Chikamoto K, Saito Y, Iwasaki Y, Teraguchi A, Lan F, Kikuchi A, Takeshita Y, Murao K, Matsugo S, Kaneko S, Misu H, Takamura T.
  • Journal Title: J Biol Chem. Volume: 292 Issue: 26 Pages: 10791-10800
  • DOI: 10.1074/jbc.m116.747006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Weight-adjusted lean body mass and calf circumference are protective against obesity-associated insulin resistance and metabolic abnormalities. (2017)
  • Author(s): Takamura T, Kita Y, Nakagen M, Sakurai M, Isobe Y, Takeshita Y, Kawai K, Urabe T, Kaneko S.
  • Journal Title: Heliyon. Volume: 3 Issue: 7 Pages: e00347-e00347
  • DOI: 10.1016/j.heliyon.2017.e00347
  • Peer Reviewed / Open Access
• [Journal Article] Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models (2017)
  • Author(s): Mita Yuichiro、Nakayama Kaho、Inari Shogo、Nishito Yukina、Yoshioka Yuya、Sakai Naoko、Sotani Kanade、Nagamura Takahiro、Kuzuhara Yuki、Inagaki Kumi、Iwasaki Miki、Misu Hirofumi、Ikegawa Masaya、Takamura Toshinari、Noguchi Noriko、Saito Yoshiro
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 1658-1658
  • DOI: 10.1038/s41467-017-01863-z
  • Peer Reviewed / Open Access
• [Presentation] 連続肝生検研究からみたNAFLD病理進展におよぼす糖尿病の意義 (2021)
  • Author(s): 迫 佐央理, 竹下 有美枝, 安藤 仁, 金子 周一, 篁 俊成
  • Organizer: 第64回 日本糖尿病学会年次学術集会
  • Invited
• [Presentation] セレノタンパク質Pを介した還元ストレスは褐色脂肪における寒冷誘発性のUCP1活性化と熱産生を障害する (2021)
  • Author(s): Oo Hein Ko, 高山 浩昭, Oo Swe Mar, 石井 清朗, 篁 俊成
  • Organizer: 第64回 日本糖尿病学会年次学術集会
• [Presentation] Novel role of selenoprotein P in immunity (2020)
  • Author(s): 篁俊成
  • Organizer: 第63回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] NAFLD/NASH研究の最前線～連続肝生検から見えてきたdiabetic steatohepatitis～ (2020)
  • Author(s): 篁俊成
  • Organizer: 第63回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] 摂取カロリー設定と3大栄養素バランスに関する論考 Issues on dietary calorie and macronutrient balance (2019)
  • Author(s): 篁 俊成
  • Organizer: 第92回日本内分泌学会学術総会
  • Invited
• [Presentation] Diabetes-associated systemic pathology induced by hepatokines (2019)
  • Author(s): 御簾 博文，篁 俊成
  • Organizer: 第63回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] 抗酸化ヘパトカイン”セレノプロテインP”が惹起する全身の糖尿病関連病態 (2019)
  • Author(s): 高山 浩昭、御簾 博文、斎藤 芳郎、篁 俊成
  • Organizer: 第92回日本生化学会大会
  • Invited
• [Presentation] EPA製剤が2型糖尿病患者の血中セレノプロテインP濃度と臓器特異的インスリン感受性に及ぼす効果 (2019)
  • Author(s): 寺村 千里，竹下 有美枝，高山 浩昭 ，海古井 由佳，田中 健雄，金森 岳広，篁 俊成
  • Organizer: 第34回日本糖尿病合併症学会
• [Presentation] インスリン抵抗性や運動抵抗性を惹起するセレノプロテインPに対するEPAの制御機構 (2019)
  • Author(s): 鴨下 恭子，石井 清明，田島 奈津美，白崎 尚芳，高山 浩昭，竹下 有美枝，金子 周一，篁 俊成
  • Organizer: 第34回日本糖尿病合併症学会
• [Presentation] Anti-oxidative hepatokine selenoprotein P impairs brown fat thermogenesis by suppressing mitochondrial ROS (2019)
  • Author(s): Hiroaki Takayama, Swe Mar Oo, Hirofumi Misu, Kiyo-aki Ishii, Toshinari Takamura
  • Organizer: Keystone Symposia Obesity and Adipose Tissue Biology
  • Int'l Joint Research
• [Presentation] 非アルコール性脂肪性肝疾患のReal-World Date：肝病理進展に寄与する病態 (2019)
  • Author(s): 篁 俊成
  • Organizer: 第53回糖尿病学の進歩
  • Invited
• [Presentation] Gamma-glutamyltransferase levels reflect glycaemic status in type 2 diabetic people treated with an SGLT2 inhibitor (2018)
  • Author(s): T. Takamura, K. Kaku, A. Yoshida, H. Kusakabe, H. Suganami
  • Organizer: the 54th EASD Annual Meeting 2018 in Berlin, Germany
  • Int'l Joint Research
• [Presentation] 肝臓-骨格筋連関が形成する糖尿病の新病態 (2018)
  • Author(s): 篁 俊成
  • Organizer: 第5回肝臓と糖尿病・代謝研究会
  • Invited
• [Presentation] Lessons from type 2 diabetic liver (2018)
  • Author(s): 篁 俊成
  • Organizer: 第84回日本生化学会東北支部会
  • Invited
• [Presentation] 脂肪肝とインスリン抵抗性 (2018)
  • Author(s): 篁 俊成
  • Organizer: 第52回糖尿病学の進歩
  • Invited
• [Presentation] 肝臓-骨格筋連関が形成する糖尿病の病態 (2018)
  • Author(s): 篁 俊成
  • Organizer: 日本薬学会第138年会
  • Invited
• [Presentation] 肥満症治療におけるヘパトカインの意義 (2017)
  • Author(s): 篁 俊成
  • Organizer: 第35回日本肥満症治療学会学術集会
  • Invited
• [Presentation] 肝臓から考える肥満2型糖尿病治療 (2017)
  • Author(s): 篁 俊成
  • Organizer: 第38回日本肥満学会
  • Invited
• [Book] 内科学 第12版 (2022)
  • Author(s): 篁 俊成（矢﨑 義雄、小室 一成 編）
  • Total Pages: 2572
  • Publisher: 朝倉書店
  • ISBN: 9784254322804
• [Book] 「ビタミン欠乏症・過剰症・依存症」 (2021)
  • Author(s): 篁俊成
  • Total Pages: 3
  • Publisher: 医学書院
• [Book] Non-Alcoholic Fatty Liver Diseases (2019)
  • Author(s): Shuichi Kaneko, Toshinari Takamura, Hirofumi Misu
  • Total Pages: 202
  • Publisher: Wiley
  • ISBN: 9784939028687
• [Remarks] 金沢大学 内分泌・代謝内科学
  • URL: https://metabology.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学 内分泌・代謝内科学
  • URL: https://www.facebook.com/TakamuraLab/
• [Remarks] 金沢大学大学院 医学系研究科 内分泌・代謝内科学分野
  • URL: https://metabology.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学大学院医学系研究科 内分泌・代謝内科学分野
  • URL: https://metabology.w3.kanazawa-u.ac.jp/
• [Remarks] 運動の効果に個人差がある原因の一つを解明
  • URL: https://www.kanazawa-u.ac.jp/rd/44241
• [Remarks] 膵臓のインスリン産生とインスリン抵抗性の両方を改善する物質を世界で初めて発見
  • URL: https://www.doshisha.ac.jp/news/2017/1122/news-detail-5377.html