| Project/Area Number |
17H04202
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Juntendo University |
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Principal Investigator |
WATADA HIROTAKA 順天堂大学, 医学(系)研究科(研究院), 教授 (60343480)
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| Co-Investigator(Kenkyū-buntansha) |
西田 友哉 順天堂大学, 医学部, 准教授 (10581449)
宮塚 健 順天堂大学, 医学(系)研究科(研究院), 准教授 (60622363)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 糖尿病 / 膵β細胞 / インスリン / グルカゴン / オートファジー / マイトファジー / 膵α細胞 / ２型糖尿病 |
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| Outline of Final Research Achievements |
We have previously demonstrated that autophagy plays an important role in maintenance of pancreatic β-cell function. However, it is not clear whether the acquired autophagy deficiency observed in type 2 diabetes causes pancreatic β-cell failure. Therefore, this time, we established the mice with inducible autophagy deficiency of pancreatic β cells, and examined the glucose metabolism of the mice. As a result, it was revealed that continuation of autophagy deficiency for several weeks causes pancreatic β-cell failure. Furthermore, we revealed that autophagy deficiency in pancreatic α cells is not directly involved in abnormal glucose metabolism, and BCL2L13, a mammalian homologue of Atg32, a recently identified molecule essential for mitophagy, is not involved in the maintenance of pancreatic β cell function.
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| Academic Significance and Societal Importance of the Research Achievements |
我々の研究グループは、膵β細胞におけるオートファジー機能不全が膵β細胞機能不全に関与することを世界に先駆けて解明し、この分野における世界のリーダー的立場にいる。本研究はこれまでの研究を継承し、膵β細胞機能不全とオートファジー機能不全の一端を解明した。本研究の結果は、２型糖尿病における膵島不全の病態解明に貢献し、新規糖尿病治療薬の分子標的の発見につながる可能性がある。
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