| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
AMP kinase (AMPK), a metabolic sensor that is activated by energy deficiency, plays an important role in the control of energy metabolism. We found that mice expressing dominant negative AMPK (DN-AMPK Tg) in skeletal muscle dramatically imporve metabolic abonormalities such as hyperglycemia, hyperlipidemia and high fatty acids levels of streptozotocin-treated diabeteci miceand extended the survival rate. Studies with recombinat proteins and neutral antibodies for myokines including IL-6 and myonectin revealed that the effects of DN-AMPK Tg in skeletal muscle on STZ diabetes are associated with changes in plasma myokine levles secreted from skeletal muscle.
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