| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
T cells and B cells are generated from hematopoietic stem cells (HSCs). HSCs gradually specify their fates to finally commit to the B cell lineage. Transcription factors and epigenetic modification play pivotal roles in the cell fate decision. However, the molecular mechanisms are largely unknown. We have recently found that the Polycomb group protein, PCGF1 was important for the B cell lineage specification from HSCs. B cell development in bone marrow of PCGF1-deficient mice was severely impaired, while T cells were normally generated. The expression of meyloid and stem cell genes was derepressed in PCGF1-deficent hematopoietic progenitors. Knock-down of the upregulated genes partially restored the B cell generation. Thus, these results indicate that PCGF1 is an essential epigenetic regulator for early B cell differentiation.
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