| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Outline of Final Research Achievements |
Accumulating evidence has indicated that gut environment is important for the development of autoimmune diseases (ADs). We found that the existence of dysbiosis in patients with multiple sclerosis characterized with the decrease of short-chain fatty acids and their producing bacteria. Among them, administration of Eubacterium rectale and Megamonas funiformis ameliorated experimental autoimmune encephalomyelitis. M. funiformis also reduced the demyelination in cuprizone-induced demyelination model. We revealed that mucosal-associated invariant T (MAIT) cells, mainly located in intestine, are involved in the exacerbation of disease of lupus model and colitis model using MR1 deficient mice. Moreover, we synthesized the inhibitory ligand for MAIT cells and it’s administration ameliorated the disease severity of these models. Further studies to reveal the mechanisms how MAIT cells aggravate these diseases will provide new therapeutic targets for the treatment and prevent of ADs.
|
