Investigations for Effective Therapies for Human Parechovirus Type 3 Infection

• Project/Area Number: 17H04226
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Niigata University
• Principal Investigator: Saitoh Akihiko 新潟大学, 医歯学系, 教授 (30531389)
• Co-Investigator(Kenkyū-buntansha): 渡邉 香奈子 新潟大学, 医歯学系, 准教授 (80626094) ; 今井 千速 新潟大学, 医歯学系, 准教授 (90419284)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: パレコウイルスA3 / 新生児 / 乳児 / 治療 / 小児 / ヒトパレコウイルス3型 / 移行抗体 / モノクローナル抗体 / 敗血症 / パレコウイルス / ウイルス

Outline of Final Research Achievements

There has been no specific treatment for parechovirus-A3 (PeV-A3) infection, which causes severe infection in neonates and young infants. We evaluated the effectiveness of antimicrobials for PeV-A3 using in vitro models.　As a results, we found inhibition effects of soem antimicrobials for PeV-A3. These medications could lead to the future treatment strategies for PeV-A3 infection.

Academic Significance and Societal Importance of the Research Achievements

新生児、早期乳児に重症感染症をきたすパレコウイルスA3（PeV-A3)に対して、効果の期待できる薬剤の候補がIn vitroの実験細胞を用いた実験で見つかったことで、今後のPeV-A3感染症の治療戦略に役立つ可能性がある。今後、PeV-A3の迅速な診断の下、治療薬の投与のタイミングについて検討する必要がある。

Research Products

• [Journal Article] Novel scoring system for differentiating parechovirus-A3 and enterovirus infection in neonates and young infants (2020)
  • Author(s): Izumita Ryohei、Aizawa Yuta、Habuka Rie、Watanabe Kanako、Otsuka Taketo、Kitamura Nobutaka、Akazawa Kohei、Saitoh Akihiko
  • Journal Title: Journal of Clinical Virology Volume: 124 Pages: 104256-104256
  • DOI: 10.1016/j.jcv.2019.104256
  • Peer Reviewed
• [Journal Article] Parechovirus-A3 encephalitis presenting with focal seizure mimicking herpes simplex virus infection (2020)
  • Author(s): Arai Sakiko、Yamanaka Takayuki、Kasai Masashi、Fukuyama Tetsuhiro、Aizawa Yuta、Matsui Ko、Sato Masanori、Matsui Hiroko、Saitoh Akihiko
  • Journal Title: Journal of Infection and Chemotherapy Volume: 26 Issue: 7 Pages: 736-740
  • DOI: 10.1016/j.jiac.2020.02.003
  • Peer Reviewed
• [Journal Article] Innate Immune Responses in Serum and Cerebrospinal Fluid From Neonates and Infants Infected With Parechovirus-A3 or Enteroviruses (2020)
  • Author(s): Habuka Rie、Aizawa Yuta、Izumita Ryohei、Domon Hisanori、Terao Yutaka、Takihara Hayato、Okuda Shujiro、Saitoh Akihiko
  • Journal Title: The Journal of Infectious Diseases Volume: in press Issue: 4 Pages: 681-689
  • DOI: 10.1093/infdis/jiaa131
  • Peer Reviewed
• [Journal Article] Persistence of High Neutralizing Antibody Titers after Neonatal and Early Infantile Infection with Parechovirus-A3. (2018)
  • Author(s): Izumita R, Aizawa Y, Watanabe K, Saitoh A.
  • Journal Title: Pediatr Infect Dis J. Volume: in press Issue: 7 Pages: e159-e161
  • DOI: 10.1097/inf.0000000000002245
  • Peer Reviewed
• [Journal Article] Intrafamilial Transmission of Parechovirus A and Enteroviruses in Neonates and Young Infants. (2018)
  • Author(s): Izumita R, Deuchi K, Aizawa Y, Habuka R, Watanabe K, Otsuka T, Saitoh A.
  • Journal Title: J Pediatric Infect Dis Soc. Volume: in press Issue: 6 Pages: 501-506
  • DOI: 10.1093/jpids/piy079
  • Peer Reviewed
• [Journal Article] Human parechovirus type 3 infection: An emerging infection in neonates and young infants. (2017)
  • Author(s): Aizawa Y, Izumita, R, Saitoh A
  • Journal Title: J Infect Chemother Volume: in press Issue: 7 Pages: 419-426
  • DOI: 10.1016/j.jiac.2017.04.009
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Neutralizing Antibody Titers against Parechovirus-A3 (PeV-A3) and Long-term Neurological Outcome in Children who Suffered from PeV-A3-Related Diseases in Neonatal and Infantile Periods. (2019)
  • Author(s): Izumita R, Aizawa Y, Watanabe K, Saitoh A.
  • Organizer: The 9th Asian Congress of Pediatric Infectious Diseases
  • Int'l Joint Research
• [Presentation] Innate Immune Response in Serum and Cerebrospinal Fluid of Neonates and Infants Infected with Parechovirus-A3 and Enteroviruses. (2019)
  • Author(s): Habuka R, Aizawa Y, Izumita R, Domon H, Terao Y, Saitoh A.
  • Organizer: ID Week, 57th Annual Meeting, Infectious Disease Society of America
  • Int'l Joint Research
• [Presentation] Human Breast Milk Inhibits Replication of Parechovirus-A3. (2019)
  • Author(s): Izumita R, Kon K, Aizawa Y, Watanabe K, Saitoh A.
  • Organizer: ID Week, 57th Annual Meeting, Infectious Disease Society of America
  • Int'l Joint Research
• [Presentation] Changing Epidemiological Profile of Infantile Parechovirus-A3 Infection in Japan. (2019)
  • Author(s): Aizawa Y, Izumita R, Yamanaka T, Habuka R, Ikuse T, Watanabe K, Otsuka T, Saitoh A.
  • Organizer: ID Week, 57th Annual Meeting, Infectious Disease Society of America
  • Int'l Joint Research
• [Presentation] Neutralizing Antibody Titers against Parechovirus-A3 (PeV-A3) and Long-term Neurological Outcome in Children who Suffered from Pev-A3-Related Diseases in Neonatal and Infantile Periods. (2018)
  • Author(s): Izumita R, Aizawa Y, Watanabe K, Saitoh A.
  • Organizer: Infectious Disease Society of America, 56th Annual Meeting
  • Int'l Joint Research
• [Presentation] Parechovirus-A3 Infection; Emerging Infection in Neonates and Young Infants (2018)
  • Author(s): Saitoh A.
  • Organizer: The 9th Asian Congress of Pediatric Infectious Diseases
  • Int'l Joint Research / Invited
• [Presentation] Can We Distinguish between Human Parechovirus Type 3 and Enteroviruses Infection in Neonates and Young Infants Based on their Clinical and Laboratory Findings? (2017)
  • Author(s): Izumita R, Aizawa Y, Habuka R, Watanabe K, Otsuka T, Saitoh A.
  • Organizer: Infectious Disease Society of America, 55th Annual Meeting
  • Int'l Joint Research
• [Presentation] Asymptomatic Adults and Children Can Transmit Human Parechoviruses and Enteroviruses to Neonates and Young Infants. (2017)
  • Author(s): Izumita R, Aizawa Y, Watanabe K, Saitoh A.
  • Organizer: Infectious Disease Society of America, 55th Annual Meeting
  • Int'l Joint Research
• [Presentation] 小児と成人におけるパレコウイルス感染症 (2017)
  • Author(s): 齋藤昭彦
  • Organizer: 第66回日本感染症学会 東日本地方会学術集会
• [Presentation] Human Parechovirus Type 3 Infection; Emerging Infection in Neonates and Young Infants (2017)
  • Author(s): Saitoh A
  • Organizer: Pediatric Academic Societies 2017 Meeting
  • Int'l Joint Research / Invited
• [Remarks]
  • URL: https://www.med.niigata-u.ac.jp/ped/