| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
Atopic dermatitis is increasing worldwide, and we consider air pollution to be one of its causes. Polycyclic aromatic hydrocarbons in air pollutants activate the Aryl hydrocarbon receptor (AhR), which develops itching and skin inflammation. We separated immune cells from the skin as single cells and analyzed them using FACS. Group 2 innate lymphoid cells were found to be involved in dermatitis together with Th2 lymphocytes. In addition, dendritic cells were also increased. Furthermore, we revealed that Ahr enhanced itching via artemin expression, but that Ahr induced dermatitis in a different mechanism.
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