Mechanical analysis of of inflammation in atopic dermatitis caused by air pollutants
| Project/Area Number |
17H04240
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Shinshu University |
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Principal Investigator |
Okuyama Ryuhei 信州大学, 学術研究院医学系, 教授 (80292332)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | AhR / アトピー性皮膚炎 / 大気汚染 / 大気汚染物質 |
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| Outline of Final Research Achievements |
Atopic dermatitis is increasing worldwide, and we consider air pollution to be one of its causes. Polycyclic aromatic hydrocarbons in air pollutants activate the Aryl hydrocarbon receptor (AhR), which develops itching and skin inflammation. We separated immune cells from the skin as single cells and analyzed them using FACS. Group 2 innate lymphoid cells were found to be involved in dermatitis together with Th2 lymphocytes. In addition, dendritic cells were also increased. Furthermore, we revealed that Ahr enhanced itching via artemin expression, but that Ahr induced dermatitis in a different mechanism.
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| Academic Significance and Societal Importance of the Research Achievements |
アトピー性皮膚炎は、外用ステロイド剤やTh2リンパ球が産生するサイトカインに対する抗体製剤などで治療が行われている。しかし、依然としてQOLの低下が著しい場合も多く、新規の治療法が求められている。この研究では、大気汚染物質がアトピー性皮膚炎の発症に深く関わると想定して、その関連性を分子細胞生物学的手法で解析した。その結果、受容体型転写因子AhRが、様々な分子の転写を制御する結果、アトピー性皮膚炎が生じることがわかり、AhRとその下流分子群が治療のターゲットとなることが明らかとなった。
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Report
(4 results)
Research Products
(86 results)
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[Journal Article] Japanese real-world study of sequential nivolumab and ipilimumab treatment in melanoma.2019
Author(s)
Tsutsumida A, Fukushima S, Yokota K, Yoshikawa S, Yamasaki O, Tanemura A, Okuyama R, Uhara H, Muto Y, Miyashita A, Akiyama M, Kaji T, Koga H, Kato J, Katayama T, Itakura E, Yamazaki N, Kiyohara Y.
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Journal Title
J Dermatol.
Volume: 46
Issue: 11
Pages: 947-955
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin.2017
Author(s)
Hidaka, T., Ogawa, E., Kobayashi, E.H., Suzuki, T., Funayama, R., Nagashima, T., Fujimura, T., Aiba, S., Nakayama, K., Okuyama, R., Yamamoto, M.
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Journal Title
Nat. Immunol.
Volume: 18
Issue: 1
Pages: 64-73
DOI
Related Report
Peer Reviewed
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